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The Benefits of Water from Nitrodi’s Spring: The In Vitro Studies Leading the Potential Clinical Applications
Natural products (water, plants, and minerals) have been studied for diverse applications in health and disease. Since there has been a growing interest in the introduction of thermal water as a clinical complementary approach in the treatment of low-grade inflammation and stress-related conditions,...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531131/ https://www.ncbi.nlm.nih.gov/pubmed/37761993 http://dx.doi.org/10.3390/ijms241813685 |
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author | Mormile, Ilaria Tuccillo, Fabiana Della Casa, Francesca D’Aiuto, Valentina Montuori, Nunzia De Rosa, Marina Napolitano, Filomena de Paulis, Amato Rossi, Francesca Wanda |
author_facet | Mormile, Ilaria Tuccillo, Fabiana Della Casa, Francesca D’Aiuto, Valentina Montuori, Nunzia De Rosa, Marina Napolitano, Filomena de Paulis, Amato Rossi, Francesca Wanda |
author_sort | Mormile, Ilaria |
collection | PubMed |
description | Natural products (water, plants, and minerals) have been studied for diverse applications in health and disease. Since there has been a growing interest in the introduction of thermal water as a clinical complementary approach in the treatment of low-grade inflammation and stress-related conditions, this review focuses on the oldest spa in the world: Nitrodi’s spring. Substantial studies in the 1960s showed that both the internal and external use of Nitrodi’s water yielded several benefits in physiological processes and in treating certain disorders, mainly allergic and autoimmune inflammatory conditions. More recently, a novel interest in Nitrodi’s water has prompted researchers to further explore the effects of this water and shed light on the molecular mechanisms sustaining its therapeutic efficacy. In different epithelial cell models, Nitrodi’s water had strong promotional effects on proliferation, cell migration, cell viability, and fibroblast to myofibroblast transition, all of which essential for wound healing and tissue remodeling. Moreover, Nitrodi’s water exhibited anti-oxidant and anti-inflammatory properties through the inhibition of ROS production and protein S-nitrosylation. Here, we have collected the clinical and basic data on Nitrodi’s water and reviewed articles that have discussed its use as a potential treatment for several inflammatory and autoimmune diseases and age-related skin deterioration. |
format | Online Article Text |
id | pubmed-10531131 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105311312023-09-28 The Benefits of Water from Nitrodi’s Spring: The In Vitro Studies Leading the Potential Clinical Applications Mormile, Ilaria Tuccillo, Fabiana Della Casa, Francesca D’Aiuto, Valentina Montuori, Nunzia De Rosa, Marina Napolitano, Filomena de Paulis, Amato Rossi, Francesca Wanda Int J Mol Sci Review Natural products (water, plants, and minerals) have been studied for diverse applications in health and disease. Since there has been a growing interest in the introduction of thermal water as a clinical complementary approach in the treatment of low-grade inflammation and stress-related conditions, this review focuses on the oldest spa in the world: Nitrodi’s spring. Substantial studies in the 1960s showed that both the internal and external use of Nitrodi’s water yielded several benefits in physiological processes and in treating certain disorders, mainly allergic and autoimmune inflammatory conditions. More recently, a novel interest in Nitrodi’s water has prompted researchers to further explore the effects of this water and shed light on the molecular mechanisms sustaining its therapeutic efficacy. In different epithelial cell models, Nitrodi’s water had strong promotional effects on proliferation, cell migration, cell viability, and fibroblast to myofibroblast transition, all of which essential for wound healing and tissue remodeling. Moreover, Nitrodi’s water exhibited anti-oxidant and anti-inflammatory properties through the inhibition of ROS production and protein S-nitrosylation. Here, we have collected the clinical and basic data on Nitrodi’s water and reviewed articles that have discussed its use as a potential treatment for several inflammatory and autoimmune diseases and age-related skin deterioration. MDPI 2023-09-05 /pmc/articles/PMC10531131/ /pubmed/37761993 http://dx.doi.org/10.3390/ijms241813685 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mormile, Ilaria Tuccillo, Fabiana Della Casa, Francesca D’Aiuto, Valentina Montuori, Nunzia De Rosa, Marina Napolitano, Filomena de Paulis, Amato Rossi, Francesca Wanda The Benefits of Water from Nitrodi’s Spring: The In Vitro Studies Leading the Potential Clinical Applications |
title | The Benefits of Water from Nitrodi’s Spring: The In Vitro Studies Leading the Potential Clinical Applications |
title_full | The Benefits of Water from Nitrodi’s Spring: The In Vitro Studies Leading the Potential Clinical Applications |
title_fullStr | The Benefits of Water from Nitrodi’s Spring: The In Vitro Studies Leading the Potential Clinical Applications |
title_full_unstemmed | The Benefits of Water from Nitrodi’s Spring: The In Vitro Studies Leading the Potential Clinical Applications |
title_short | The Benefits of Water from Nitrodi’s Spring: The In Vitro Studies Leading the Potential Clinical Applications |
title_sort | benefits of water from nitrodi’s spring: the in vitro studies leading the potential clinical applications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531131/ https://www.ncbi.nlm.nih.gov/pubmed/37761993 http://dx.doi.org/10.3390/ijms241813685 |
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