Cargando…

The Benefits of Water from Nitrodi’s Spring: The In Vitro Studies Leading the Potential Clinical Applications

Natural products (water, plants, and minerals) have been studied for diverse applications in health and disease. Since there has been a growing interest in the introduction of thermal water as a clinical complementary approach in the treatment of low-grade inflammation and stress-related conditions,...

Descripción completa

Detalles Bibliográficos
Autores principales: Mormile, Ilaria, Tuccillo, Fabiana, Della Casa, Francesca, D’Aiuto, Valentina, Montuori, Nunzia, De Rosa, Marina, Napolitano, Filomena, de Paulis, Amato, Rossi, Francesca Wanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531131/
https://www.ncbi.nlm.nih.gov/pubmed/37761993
http://dx.doi.org/10.3390/ijms241813685
_version_ 1785111646300012544
author Mormile, Ilaria
Tuccillo, Fabiana
Della Casa, Francesca
D’Aiuto, Valentina
Montuori, Nunzia
De Rosa, Marina
Napolitano, Filomena
de Paulis, Amato
Rossi, Francesca Wanda
author_facet Mormile, Ilaria
Tuccillo, Fabiana
Della Casa, Francesca
D’Aiuto, Valentina
Montuori, Nunzia
De Rosa, Marina
Napolitano, Filomena
de Paulis, Amato
Rossi, Francesca Wanda
author_sort Mormile, Ilaria
collection PubMed
description Natural products (water, plants, and minerals) have been studied for diverse applications in health and disease. Since there has been a growing interest in the introduction of thermal water as a clinical complementary approach in the treatment of low-grade inflammation and stress-related conditions, this review focuses on the oldest spa in the world: Nitrodi’s spring. Substantial studies in the 1960s showed that both the internal and external use of Nitrodi’s water yielded several benefits in physiological processes and in treating certain disorders, mainly allergic and autoimmune inflammatory conditions. More recently, a novel interest in Nitrodi’s water has prompted researchers to further explore the effects of this water and shed light on the molecular mechanisms sustaining its therapeutic efficacy. In different epithelial cell models, Nitrodi’s water had strong promotional effects on proliferation, cell migration, cell viability, and fibroblast to myofibroblast transition, all of which essential for wound healing and tissue remodeling. Moreover, Nitrodi’s water exhibited anti-oxidant and anti-inflammatory properties through the inhibition of ROS production and protein S-nitrosylation. Here, we have collected the clinical and basic data on Nitrodi’s water and reviewed articles that have discussed its use as a potential treatment for several inflammatory and autoimmune diseases and age-related skin deterioration.
format Online
Article
Text
id pubmed-10531131
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-105311312023-09-28 The Benefits of Water from Nitrodi’s Spring: The In Vitro Studies Leading the Potential Clinical Applications Mormile, Ilaria Tuccillo, Fabiana Della Casa, Francesca D’Aiuto, Valentina Montuori, Nunzia De Rosa, Marina Napolitano, Filomena de Paulis, Amato Rossi, Francesca Wanda Int J Mol Sci Review Natural products (water, plants, and minerals) have been studied for diverse applications in health and disease. Since there has been a growing interest in the introduction of thermal water as a clinical complementary approach in the treatment of low-grade inflammation and stress-related conditions, this review focuses on the oldest spa in the world: Nitrodi’s spring. Substantial studies in the 1960s showed that both the internal and external use of Nitrodi’s water yielded several benefits in physiological processes and in treating certain disorders, mainly allergic and autoimmune inflammatory conditions. More recently, a novel interest in Nitrodi’s water has prompted researchers to further explore the effects of this water and shed light on the molecular mechanisms sustaining its therapeutic efficacy. In different epithelial cell models, Nitrodi’s water had strong promotional effects on proliferation, cell migration, cell viability, and fibroblast to myofibroblast transition, all of which essential for wound healing and tissue remodeling. Moreover, Nitrodi’s water exhibited anti-oxidant and anti-inflammatory properties through the inhibition of ROS production and protein S-nitrosylation. Here, we have collected the clinical and basic data on Nitrodi’s water and reviewed articles that have discussed its use as a potential treatment for several inflammatory and autoimmune diseases and age-related skin deterioration. MDPI 2023-09-05 /pmc/articles/PMC10531131/ /pubmed/37761993 http://dx.doi.org/10.3390/ijms241813685 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mormile, Ilaria
Tuccillo, Fabiana
Della Casa, Francesca
D’Aiuto, Valentina
Montuori, Nunzia
De Rosa, Marina
Napolitano, Filomena
de Paulis, Amato
Rossi, Francesca Wanda
The Benefits of Water from Nitrodi’s Spring: The In Vitro Studies Leading the Potential Clinical Applications
title The Benefits of Water from Nitrodi’s Spring: The In Vitro Studies Leading the Potential Clinical Applications
title_full The Benefits of Water from Nitrodi’s Spring: The In Vitro Studies Leading the Potential Clinical Applications
title_fullStr The Benefits of Water from Nitrodi’s Spring: The In Vitro Studies Leading the Potential Clinical Applications
title_full_unstemmed The Benefits of Water from Nitrodi’s Spring: The In Vitro Studies Leading the Potential Clinical Applications
title_short The Benefits of Water from Nitrodi’s Spring: The In Vitro Studies Leading the Potential Clinical Applications
title_sort benefits of water from nitrodi’s spring: the in vitro studies leading the potential clinical applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531131/
https://www.ncbi.nlm.nih.gov/pubmed/37761993
http://dx.doi.org/10.3390/ijms241813685
work_keys_str_mv AT mormileilaria thebenefitsofwaterfromnitrodisspringtheinvitrostudiesleadingthepotentialclinicalapplications
AT tuccillofabiana thebenefitsofwaterfromnitrodisspringtheinvitrostudiesleadingthepotentialclinicalapplications
AT dellacasafrancesca thebenefitsofwaterfromnitrodisspringtheinvitrostudiesleadingthepotentialclinicalapplications
AT daiutovalentina thebenefitsofwaterfromnitrodisspringtheinvitrostudiesleadingthepotentialclinicalapplications
AT montuorinunzia thebenefitsofwaterfromnitrodisspringtheinvitrostudiesleadingthepotentialclinicalapplications
AT derosamarina thebenefitsofwaterfromnitrodisspringtheinvitrostudiesleadingthepotentialclinicalapplications
AT napolitanofilomena thebenefitsofwaterfromnitrodisspringtheinvitrostudiesleadingthepotentialclinicalapplications
AT depaulisamato thebenefitsofwaterfromnitrodisspringtheinvitrostudiesleadingthepotentialclinicalapplications
AT rossifrancescawanda thebenefitsofwaterfromnitrodisspringtheinvitrostudiesleadingthepotentialclinicalapplications
AT mormileilaria benefitsofwaterfromnitrodisspringtheinvitrostudiesleadingthepotentialclinicalapplications
AT tuccillofabiana benefitsofwaterfromnitrodisspringtheinvitrostudiesleadingthepotentialclinicalapplications
AT dellacasafrancesca benefitsofwaterfromnitrodisspringtheinvitrostudiesleadingthepotentialclinicalapplications
AT daiutovalentina benefitsofwaterfromnitrodisspringtheinvitrostudiesleadingthepotentialclinicalapplications
AT montuorinunzia benefitsofwaterfromnitrodisspringtheinvitrostudiesleadingthepotentialclinicalapplications
AT derosamarina benefitsofwaterfromnitrodisspringtheinvitrostudiesleadingthepotentialclinicalapplications
AT napolitanofilomena benefitsofwaterfromnitrodisspringtheinvitrostudiesleadingthepotentialclinicalapplications
AT depaulisamato benefitsofwaterfromnitrodisspringtheinvitrostudiesleadingthepotentialclinicalapplications
AT rossifrancescawanda benefitsofwaterfromnitrodisspringtheinvitrostudiesleadingthepotentialclinicalapplications