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Circadian Gene Variants in Diseases
The circadian rhythm is a self-sustaining 24 h cycle that regulates physiological processes within the body, including cycles of alertness and sleepiness. Cells have their own intrinsic clock, which consists of several proteins that regulate the circadian rhythm of each individual cell. The core of...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531145/ https://www.ncbi.nlm.nih.gov/pubmed/37761843 http://dx.doi.org/10.3390/genes14091703 |
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author | Gršković, Paula Korać, Petra |
author_facet | Gršković, Paula Korać, Petra |
author_sort | Gršković, Paula |
collection | PubMed |
description | The circadian rhythm is a self-sustaining 24 h cycle that regulates physiological processes within the body, including cycles of alertness and sleepiness. Cells have their own intrinsic clock, which consists of several proteins that regulate the circadian rhythm of each individual cell. The core of the molecular clock in human cells consists of four main circadian proteins that work in pairs. The CLOCK-BMAL1 heterodimer and the PER-CRY heterodimer each regulate the other pair’s expression, forming a negative feedback loop. Several other proteins are involved in regulating the expression of the main circadian genes, and can therefore also influence the circadian rhythm of cells. This review focuses on the existing knowledge regarding circadian gene variants in both the main and secondary circadian genes, and their association with various diseases, such as tumors, metabolic diseases, cardiovascular diseases, and sleep disorders. |
format | Online Article Text |
id | pubmed-10531145 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105311452023-09-28 Circadian Gene Variants in Diseases Gršković, Paula Korać, Petra Genes (Basel) Review The circadian rhythm is a self-sustaining 24 h cycle that regulates physiological processes within the body, including cycles of alertness and sleepiness. Cells have their own intrinsic clock, which consists of several proteins that regulate the circadian rhythm of each individual cell. The core of the molecular clock in human cells consists of four main circadian proteins that work in pairs. The CLOCK-BMAL1 heterodimer and the PER-CRY heterodimer each regulate the other pair’s expression, forming a negative feedback loop. Several other proteins are involved in regulating the expression of the main circadian genes, and can therefore also influence the circadian rhythm of cells. This review focuses on the existing knowledge regarding circadian gene variants in both the main and secondary circadian genes, and their association with various diseases, such as tumors, metabolic diseases, cardiovascular diseases, and sleep disorders. MDPI 2023-08-27 /pmc/articles/PMC10531145/ /pubmed/37761843 http://dx.doi.org/10.3390/genes14091703 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gršković, Paula Korać, Petra Circadian Gene Variants in Diseases |
title | Circadian Gene Variants in Diseases |
title_full | Circadian Gene Variants in Diseases |
title_fullStr | Circadian Gene Variants in Diseases |
title_full_unstemmed | Circadian Gene Variants in Diseases |
title_short | Circadian Gene Variants in Diseases |
title_sort | circadian gene variants in diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531145/ https://www.ncbi.nlm.nih.gov/pubmed/37761843 http://dx.doi.org/10.3390/genes14091703 |
work_keys_str_mv | AT grskovicpaula circadiangenevariantsindiseases AT koracpetra circadiangenevariantsindiseases |