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Circadian Gene Variants in Diseases

The circadian rhythm is a self-sustaining 24 h cycle that regulates physiological processes within the body, including cycles of alertness and sleepiness. Cells have their own intrinsic clock, which consists of several proteins that regulate the circadian rhythm of each individual cell. The core of...

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Autores principales: Gršković, Paula, Korać, Petra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531145/
https://www.ncbi.nlm.nih.gov/pubmed/37761843
http://dx.doi.org/10.3390/genes14091703
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author Gršković, Paula
Korać, Petra
author_facet Gršković, Paula
Korać, Petra
author_sort Gršković, Paula
collection PubMed
description The circadian rhythm is a self-sustaining 24 h cycle that regulates physiological processes within the body, including cycles of alertness and sleepiness. Cells have their own intrinsic clock, which consists of several proteins that regulate the circadian rhythm of each individual cell. The core of the molecular clock in human cells consists of four main circadian proteins that work in pairs. The CLOCK-BMAL1 heterodimer and the PER-CRY heterodimer each regulate the other pair’s expression, forming a negative feedback loop. Several other proteins are involved in regulating the expression of the main circadian genes, and can therefore also influence the circadian rhythm of cells. This review focuses on the existing knowledge regarding circadian gene variants in both the main and secondary circadian genes, and their association with various diseases, such as tumors, metabolic diseases, cardiovascular diseases, and sleep disorders.
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spelling pubmed-105311452023-09-28 Circadian Gene Variants in Diseases Gršković, Paula Korać, Petra Genes (Basel) Review The circadian rhythm is a self-sustaining 24 h cycle that regulates physiological processes within the body, including cycles of alertness and sleepiness. Cells have their own intrinsic clock, which consists of several proteins that regulate the circadian rhythm of each individual cell. The core of the molecular clock in human cells consists of four main circadian proteins that work in pairs. The CLOCK-BMAL1 heterodimer and the PER-CRY heterodimer each regulate the other pair’s expression, forming a negative feedback loop. Several other proteins are involved in regulating the expression of the main circadian genes, and can therefore also influence the circadian rhythm of cells. This review focuses on the existing knowledge regarding circadian gene variants in both the main and secondary circadian genes, and their association with various diseases, such as tumors, metabolic diseases, cardiovascular diseases, and sleep disorders. MDPI 2023-08-27 /pmc/articles/PMC10531145/ /pubmed/37761843 http://dx.doi.org/10.3390/genes14091703 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gršković, Paula
Korać, Petra
Circadian Gene Variants in Diseases
title Circadian Gene Variants in Diseases
title_full Circadian Gene Variants in Diseases
title_fullStr Circadian Gene Variants in Diseases
title_full_unstemmed Circadian Gene Variants in Diseases
title_short Circadian Gene Variants in Diseases
title_sort circadian gene variants in diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531145/
https://www.ncbi.nlm.nih.gov/pubmed/37761843
http://dx.doi.org/10.3390/genes14091703
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