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Relationship of Hepatocellular Carcinoma Stage and Hepatic Function to Health-Related Quality of Life: A Single Center Analysis
Health-related quality of life (HRQoL) is known to be an important prognostic indicator and clinical endpoint for patients with hepatocellular carcinoma (HCC). However, the correlation of the Barcelona Clinic Liver Cancer (BCLC) stage with HRQoL in HCC has not been previously studied. We examined th...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531156/ https://www.ncbi.nlm.nih.gov/pubmed/37761768 http://dx.doi.org/10.3390/healthcare11182571 |
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author | Gupta, Amol Zorzi, Jane Ho, Won Jin Baretti, Marina Azad, Nilofer Saba Griffith, Paige Dao, Doan Kim, Amy Philosophe, Benjamin Georgiades, Christos Kamel, Ihab Burkhart, Richard Liddell, Robert Hong, Kelvin Shubert, Christopher Lafaro, Kelly Meyer, Jeffrey Anders, Robert Burns III, William Yarchoan, Mark |
author_facet | Gupta, Amol Zorzi, Jane Ho, Won Jin Baretti, Marina Azad, Nilofer Saba Griffith, Paige Dao, Doan Kim, Amy Philosophe, Benjamin Georgiades, Christos Kamel, Ihab Burkhart, Richard Liddell, Robert Hong, Kelvin Shubert, Christopher Lafaro, Kelly Meyer, Jeffrey Anders, Robert Burns III, William Yarchoan, Mark |
author_sort | Gupta, Amol |
collection | PubMed |
description | Health-related quality of life (HRQoL) is known to be an important prognostic indicator and clinical endpoint for patients with hepatocellular carcinoma (HCC). However, the correlation of the Barcelona Clinic Liver Cancer (BCLC) stage with HRQoL in HCC has not been previously studied. We examined the relationship between BCLC stage, Child–Pugh (CP) score, and Eastern Cooperative Oncology Group (ECOG) performance status on HRQoL for patients who presented at a multidisciplinary liver cancer clinic. HRQoL was assessed using the Functional Assessment of Cancer Therapy-Hepatobiliary (FACT-Hep) questionnaire. Fifty-one patients met our inclusion criteria. The FACT-Hep total and subscales showed no significant association with BCLC stages (p = 0.224). Patients with CP B had significantly more impairment in FACT-Hep than patients with CP A. These data indicate that in patients with HCC, impaired liver function is associated with reduced quality of life, whereas the BCLC stage poorly correlates with quality of life metrics. Impairment of quality of life is common in HCC patients and further studies are warranted to determine the impact of early supportive interventions on HRQoL and survival outcomes. |
format | Online Article Text |
id | pubmed-10531156 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105311562023-09-28 Relationship of Hepatocellular Carcinoma Stage and Hepatic Function to Health-Related Quality of Life: A Single Center Analysis Gupta, Amol Zorzi, Jane Ho, Won Jin Baretti, Marina Azad, Nilofer Saba Griffith, Paige Dao, Doan Kim, Amy Philosophe, Benjamin Georgiades, Christos Kamel, Ihab Burkhart, Richard Liddell, Robert Hong, Kelvin Shubert, Christopher Lafaro, Kelly Meyer, Jeffrey Anders, Robert Burns III, William Yarchoan, Mark Healthcare (Basel) Article Health-related quality of life (HRQoL) is known to be an important prognostic indicator and clinical endpoint for patients with hepatocellular carcinoma (HCC). However, the correlation of the Barcelona Clinic Liver Cancer (BCLC) stage with HRQoL in HCC has not been previously studied. We examined the relationship between BCLC stage, Child–Pugh (CP) score, and Eastern Cooperative Oncology Group (ECOG) performance status on HRQoL for patients who presented at a multidisciplinary liver cancer clinic. HRQoL was assessed using the Functional Assessment of Cancer Therapy-Hepatobiliary (FACT-Hep) questionnaire. Fifty-one patients met our inclusion criteria. The FACT-Hep total and subscales showed no significant association with BCLC stages (p = 0.224). Patients with CP B had significantly more impairment in FACT-Hep than patients with CP A. These data indicate that in patients with HCC, impaired liver function is associated with reduced quality of life, whereas the BCLC stage poorly correlates with quality of life metrics. Impairment of quality of life is common in HCC patients and further studies are warranted to determine the impact of early supportive interventions on HRQoL and survival outcomes. MDPI 2023-09-18 /pmc/articles/PMC10531156/ /pubmed/37761768 http://dx.doi.org/10.3390/healthcare11182571 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Gupta, Amol Zorzi, Jane Ho, Won Jin Baretti, Marina Azad, Nilofer Saba Griffith, Paige Dao, Doan Kim, Amy Philosophe, Benjamin Georgiades, Christos Kamel, Ihab Burkhart, Richard Liddell, Robert Hong, Kelvin Shubert, Christopher Lafaro, Kelly Meyer, Jeffrey Anders, Robert Burns III, William Yarchoan, Mark Relationship of Hepatocellular Carcinoma Stage and Hepatic Function to Health-Related Quality of Life: A Single Center Analysis |
title | Relationship of Hepatocellular Carcinoma Stage and Hepatic Function to Health-Related Quality of Life: A Single Center Analysis |
title_full | Relationship of Hepatocellular Carcinoma Stage and Hepatic Function to Health-Related Quality of Life: A Single Center Analysis |
title_fullStr | Relationship of Hepatocellular Carcinoma Stage and Hepatic Function to Health-Related Quality of Life: A Single Center Analysis |
title_full_unstemmed | Relationship of Hepatocellular Carcinoma Stage and Hepatic Function to Health-Related Quality of Life: A Single Center Analysis |
title_short | Relationship of Hepatocellular Carcinoma Stage and Hepatic Function to Health-Related Quality of Life: A Single Center Analysis |
title_sort | relationship of hepatocellular carcinoma stage and hepatic function to health-related quality of life: a single center analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531156/ https://www.ncbi.nlm.nih.gov/pubmed/37761768 http://dx.doi.org/10.3390/healthcare11182571 |
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