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Mammal Reproductive Homeobox (Rhox) Genes: An Update of Their Involvement in Reproduction and Development
The reproductive homeobox on the X chromosome (RHOX) genes were first identified in the mouse during the 1990s and have a crucial role in reproduction. In various transcription factors with a key regulatory role, the homeobox sequence encodes a “homeodomain” DNA-binding motif. In the mouse, there ar...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531175/ https://www.ncbi.nlm.nih.gov/pubmed/37761825 http://dx.doi.org/10.3390/genes14091685 |
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author | Le Beulze, Morgane Daubech, Cécile Balde-Camara, Aissatu Ghieh, Farah Vialard, François |
author_facet | Le Beulze, Morgane Daubech, Cécile Balde-Camara, Aissatu Ghieh, Farah Vialard, François |
author_sort | Le Beulze, Morgane |
collection | PubMed |
description | The reproductive homeobox on the X chromosome (RHOX) genes were first identified in the mouse during the 1990s and have a crucial role in reproduction. In various transcription factors with a key regulatory role, the homeobox sequence encodes a “homeodomain” DNA-binding motif. In the mouse, there are three clusters of Rhox genes (α, β, and γ) on the X chromosome. Each cluster shows temporal and/or quantitative collinearity, which regulates the progression of the embryonic development process. Although the RHOX family is conserved in mammals, the interspecies differences in the number of RHOX genes and pseudogenes testifies to a rich evolutionary history with several relatively recent events. In the mouse, Rhox genes are mainly expressed in reproductive tissues, and several have a role in the differentiation of primordial germ cells (Rhox1, Rhox6, and Rhox10) and in spermatogenesis (Rhox1, Rhox8, and Rhox13). Despite the lack of detailed data on human RHOX, these genes appear to be involved in the formation of germ cells because they are predominantly expressed during the early (RHOXF1) and late (RHOXF2/F2B) stages of germ cell development. Furthermore, the few variants identified to date are thought to induce or predispose to impaired spermatogenesis and severe oligozoospermia or azoospermia. In the future, research on the pathophysiology of the human RHOX genes is likely to confirm the essential role of this family in the reproductive process and might help us to better understand the various causes of infertility and characterize the associated human phenotypes. |
format | Online Article Text |
id | pubmed-10531175 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105311752023-09-28 Mammal Reproductive Homeobox (Rhox) Genes: An Update of Their Involvement in Reproduction and Development Le Beulze, Morgane Daubech, Cécile Balde-Camara, Aissatu Ghieh, Farah Vialard, François Genes (Basel) Review The reproductive homeobox on the X chromosome (RHOX) genes were first identified in the mouse during the 1990s and have a crucial role in reproduction. In various transcription factors with a key regulatory role, the homeobox sequence encodes a “homeodomain” DNA-binding motif. In the mouse, there are three clusters of Rhox genes (α, β, and γ) on the X chromosome. Each cluster shows temporal and/or quantitative collinearity, which regulates the progression of the embryonic development process. Although the RHOX family is conserved in mammals, the interspecies differences in the number of RHOX genes and pseudogenes testifies to a rich evolutionary history with several relatively recent events. In the mouse, Rhox genes are mainly expressed in reproductive tissues, and several have a role in the differentiation of primordial germ cells (Rhox1, Rhox6, and Rhox10) and in spermatogenesis (Rhox1, Rhox8, and Rhox13). Despite the lack of detailed data on human RHOX, these genes appear to be involved in the formation of germ cells because they are predominantly expressed during the early (RHOXF1) and late (RHOXF2/F2B) stages of germ cell development. Furthermore, the few variants identified to date are thought to induce or predispose to impaired spermatogenesis and severe oligozoospermia or azoospermia. In the future, research on the pathophysiology of the human RHOX genes is likely to confirm the essential role of this family in the reproductive process and might help us to better understand the various causes of infertility and characterize the associated human phenotypes. MDPI 2023-08-25 /pmc/articles/PMC10531175/ /pubmed/37761825 http://dx.doi.org/10.3390/genes14091685 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Le Beulze, Morgane Daubech, Cécile Balde-Camara, Aissatu Ghieh, Farah Vialard, François Mammal Reproductive Homeobox (Rhox) Genes: An Update of Their Involvement in Reproduction and Development |
title | Mammal Reproductive Homeobox (Rhox) Genes: An Update of Their Involvement in Reproduction and Development |
title_full | Mammal Reproductive Homeobox (Rhox) Genes: An Update of Their Involvement in Reproduction and Development |
title_fullStr | Mammal Reproductive Homeobox (Rhox) Genes: An Update of Their Involvement in Reproduction and Development |
title_full_unstemmed | Mammal Reproductive Homeobox (Rhox) Genes: An Update of Their Involvement in Reproduction and Development |
title_short | Mammal Reproductive Homeobox (Rhox) Genes: An Update of Their Involvement in Reproduction and Development |
title_sort | mammal reproductive homeobox (rhox) genes: an update of their involvement in reproduction and development |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531175/ https://www.ncbi.nlm.nih.gov/pubmed/37761825 http://dx.doi.org/10.3390/genes14091685 |
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