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Effects of Denture Treatment on Salivary Metabolites: A Pilot Study

Symptoms of oral discomfort such as dry mouth are common in older people wearing dentures. Such symptoms are mainly treated symptomatically. Many of these symptoms are related to saliva, and associations with salivary volume have been reported. Although denture treatment improves symptoms by increas...

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Autores principales: Ichigaya, Narumi, Kawanishi, Norishige, Adachi, Takuya, Sugimoto, Masahiro, Kimoto, Katsuhiko, Hoshi, Noriyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531179/
https://www.ncbi.nlm.nih.gov/pubmed/37762262
http://dx.doi.org/10.3390/ijms241813959
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author Ichigaya, Narumi
Kawanishi, Norishige
Adachi, Takuya
Sugimoto, Masahiro
Kimoto, Katsuhiko
Hoshi, Noriyuki
author_facet Ichigaya, Narumi
Kawanishi, Norishige
Adachi, Takuya
Sugimoto, Masahiro
Kimoto, Katsuhiko
Hoshi, Noriyuki
author_sort Ichigaya, Narumi
collection PubMed
description Symptoms of oral discomfort such as dry mouth are common in older people wearing dentures. Such symptoms are mainly treated symptomatically. Many of these symptoms are related to saliva, and associations with salivary volume have been reported. Although denture treatment improves symptoms by increasing the amount of saliva, the effects on salivary components remain unclear. This study aimed to investigate the effects of denture treatment on salivary metabolite changes based on salivary metabolome analyses. We enrolled 21 patients requiring denture treatment. At the first visit, and after completion of denture treatment, saliva outflow was measured under resting and stimulated conditions, samples for salivary metabolite analysis were collected, and masticatory efficiency was tested. In all participants, masticatory efficiency increased after denture treatment. Moreover, the amounts of resting and stimulated saliva were increased. Using salivary metabolome analysis, 61 salivary metabolites were detected. Substantial concentration changes were observed for 4 and 21 metabolites in resting and stimulated saliva, respectively. The four metabolites common to both saliva tests had significantly lower concentrations after treatment. These results suggest that the improvement in masticatory function by dentures is related not only to salivary secretion volume, but also to salivary metabolite composition.
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spelling pubmed-105311792023-09-28 Effects of Denture Treatment on Salivary Metabolites: A Pilot Study Ichigaya, Narumi Kawanishi, Norishige Adachi, Takuya Sugimoto, Masahiro Kimoto, Katsuhiko Hoshi, Noriyuki Int J Mol Sci Article Symptoms of oral discomfort such as dry mouth are common in older people wearing dentures. Such symptoms are mainly treated symptomatically. Many of these symptoms are related to saliva, and associations with salivary volume have been reported. Although denture treatment improves symptoms by increasing the amount of saliva, the effects on salivary components remain unclear. This study aimed to investigate the effects of denture treatment on salivary metabolite changes based on salivary metabolome analyses. We enrolled 21 patients requiring denture treatment. At the first visit, and after completion of denture treatment, saliva outflow was measured under resting and stimulated conditions, samples for salivary metabolite analysis were collected, and masticatory efficiency was tested. In all participants, masticatory efficiency increased after denture treatment. Moreover, the amounts of resting and stimulated saliva were increased. Using salivary metabolome analysis, 61 salivary metabolites were detected. Substantial concentration changes were observed for 4 and 21 metabolites in resting and stimulated saliva, respectively. The four metabolites common to both saliva tests had significantly lower concentrations after treatment. These results suggest that the improvement in masticatory function by dentures is related not only to salivary secretion volume, but also to salivary metabolite composition. MDPI 2023-09-11 /pmc/articles/PMC10531179/ /pubmed/37762262 http://dx.doi.org/10.3390/ijms241813959 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ichigaya, Narumi
Kawanishi, Norishige
Adachi, Takuya
Sugimoto, Masahiro
Kimoto, Katsuhiko
Hoshi, Noriyuki
Effects of Denture Treatment on Salivary Metabolites: A Pilot Study
title Effects of Denture Treatment on Salivary Metabolites: A Pilot Study
title_full Effects of Denture Treatment on Salivary Metabolites: A Pilot Study
title_fullStr Effects of Denture Treatment on Salivary Metabolites: A Pilot Study
title_full_unstemmed Effects of Denture Treatment on Salivary Metabolites: A Pilot Study
title_short Effects of Denture Treatment on Salivary Metabolites: A Pilot Study
title_sort effects of denture treatment on salivary metabolites: a pilot study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531179/
https://www.ncbi.nlm.nih.gov/pubmed/37762262
http://dx.doi.org/10.3390/ijms241813959
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