Cargando…

Phenotyping heart failure by cardiac magnetic resonance imaging of cardiac macro- and microscopic structure: state of the art review

Heart failure demographics have evolved in past decades with the development of improved diagnostics, therapies, and prevention. Cardiac magnetic resonance (CMR) has developed in a similar timeframe to become the gold-standard non-invasive imaging modality for characterizing diseases causing heart f...

Descripción completa

Detalles Bibliográficos
Autores principales: Pan, Jiliu, Ng, Sher May, Neubauer, Stefan, Rider, Oliver J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531211/
https://www.ncbi.nlm.nih.gov/pubmed/37267310
http://dx.doi.org/10.1093/ehjci/jead124
_version_ 1785111665194303488
author Pan, Jiliu
Ng, Sher May
Neubauer, Stefan
Rider, Oliver J
author_facet Pan, Jiliu
Ng, Sher May
Neubauer, Stefan
Rider, Oliver J
author_sort Pan, Jiliu
collection PubMed
description Heart failure demographics have evolved in past decades with the development of improved diagnostics, therapies, and prevention. Cardiac magnetic resonance (CMR) has developed in a similar timeframe to become the gold-standard non-invasive imaging modality for characterizing diseases causing heart failure. CMR techniques to assess cardiac morphology and function have progressed since their first use in the 1980s. Increasingly efficient acquisition protocols generate high spatial and temporal resolution images in less time. This has enabled new methods of characterizing cardiac systolic and diastolic function such as strain analysis, exercise real-time cine imaging and four-dimensional flow. A key strength of CMR is its ability to non-invasively interrogate the myocardial tissue composition. Gadolinium contrast agents revolutionized non-invasive cardiac imaging with the late gadolinium enhancement technique. Further advances enabled quantitative parametric mapping to increase sensitivity at detecting diffuse pathology. Novel methods such as diffusion tensor imaging and artificial intelligence-enhanced image generation are on the horizon. Magnetic resonance spectroscopy (MRS) provides a window into the molecular environment of the myocardium. Phosphorus ((31)P) spectroscopy can inform the status of cardiac energetics in health and disease. Proton ((1)H) spectroscopy complements this by measuring creatine and intramyocardial lipids. Hyperpolarized carbon ((13)C) spectroscopy is a novel method that could further our understanding of dynamic cardiac metabolism. CMR of other organs such as the lungs may add further depth into phenotypes of heart failure. The vast capabilities of CMR should be deployed and interpreted in context of current heart failure challenges.
format Online
Article
Text
id pubmed-10531211
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-105312112023-09-28 Phenotyping heart failure by cardiac magnetic resonance imaging of cardiac macro- and microscopic structure: state of the art review Pan, Jiliu Ng, Sher May Neubauer, Stefan Rider, Oliver J Eur Heart J Cardiovasc Imaging Review Heart failure demographics have evolved in past decades with the development of improved diagnostics, therapies, and prevention. Cardiac magnetic resonance (CMR) has developed in a similar timeframe to become the gold-standard non-invasive imaging modality for characterizing diseases causing heart failure. CMR techniques to assess cardiac morphology and function have progressed since their first use in the 1980s. Increasingly efficient acquisition protocols generate high spatial and temporal resolution images in less time. This has enabled new methods of characterizing cardiac systolic and diastolic function such as strain analysis, exercise real-time cine imaging and four-dimensional flow. A key strength of CMR is its ability to non-invasively interrogate the myocardial tissue composition. Gadolinium contrast agents revolutionized non-invasive cardiac imaging with the late gadolinium enhancement technique. Further advances enabled quantitative parametric mapping to increase sensitivity at detecting diffuse pathology. Novel methods such as diffusion tensor imaging and artificial intelligence-enhanced image generation are on the horizon. Magnetic resonance spectroscopy (MRS) provides a window into the molecular environment of the myocardium. Phosphorus ((31)P) spectroscopy can inform the status of cardiac energetics in health and disease. Proton ((1)H) spectroscopy complements this by measuring creatine and intramyocardial lipids. Hyperpolarized carbon ((13)C) spectroscopy is a novel method that could further our understanding of dynamic cardiac metabolism. CMR of other organs such as the lungs may add further depth into phenotypes of heart failure. The vast capabilities of CMR should be deployed and interpreted in context of current heart failure challenges. Oxford University Press 2023-06-02 /pmc/articles/PMC10531211/ /pubmed/37267310 http://dx.doi.org/10.1093/ehjci/jead124 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Review
Pan, Jiliu
Ng, Sher May
Neubauer, Stefan
Rider, Oliver J
Phenotyping heart failure by cardiac magnetic resonance imaging of cardiac macro- and microscopic structure: state of the art review
title Phenotyping heart failure by cardiac magnetic resonance imaging of cardiac macro- and microscopic structure: state of the art review
title_full Phenotyping heart failure by cardiac magnetic resonance imaging of cardiac macro- and microscopic structure: state of the art review
title_fullStr Phenotyping heart failure by cardiac magnetic resonance imaging of cardiac macro- and microscopic structure: state of the art review
title_full_unstemmed Phenotyping heart failure by cardiac magnetic resonance imaging of cardiac macro- and microscopic structure: state of the art review
title_short Phenotyping heart failure by cardiac magnetic resonance imaging of cardiac macro- and microscopic structure: state of the art review
title_sort phenotyping heart failure by cardiac magnetic resonance imaging of cardiac macro- and microscopic structure: state of the art review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531211/
https://www.ncbi.nlm.nih.gov/pubmed/37267310
http://dx.doi.org/10.1093/ehjci/jead124
work_keys_str_mv AT panjiliu phenotypingheartfailurebycardiacmagneticresonanceimagingofcardiacmacroandmicroscopicstructurestateoftheartreview
AT ngshermay phenotypingheartfailurebycardiacmagneticresonanceimagingofcardiacmacroandmicroscopicstructurestateoftheartreview
AT neubauerstefan phenotypingheartfailurebycardiacmagneticresonanceimagingofcardiacmacroandmicroscopicstructurestateoftheartreview
AT rideroliverj phenotypingheartfailurebycardiacmagneticresonanceimagingofcardiacmacroandmicroscopicstructurestateoftheartreview