Cargando…

The association of self-reported symptoms of central sensitization and sleep disturbances in neuropathic pain

INTRODUCTION: Patients with neuropathic pain (NP) report a higher impairment of quality of life and sleep than patients with chronic pain without neuropathic characteristics. These include somatosensory peculiarities like allodynia, a surrogate marker for central sensitization. OBJECTIVES: This stud...

Descripción completa

Detalles Bibliográficos
Autores principales: Sachau, Juliane, Kersebaum, Dilara, Hüllemann, Philipp, Adolf, Daniela, Kabelitz, Maria, Keller, Thomas, Freynhagen, Rainer, Tölle, Thomas R., Binder, Andreas, Baron, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531265/
https://www.ncbi.nlm.nih.gov/pubmed/37772033
http://dx.doi.org/10.1097/PR9.0000000000001098
_version_ 1785111677972250624
author Sachau, Juliane
Kersebaum, Dilara
Hüllemann, Philipp
Adolf, Daniela
Kabelitz, Maria
Keller, Thomas
Freynhagen, Rainer
Tölle, Thomas R.
Binder, Andreas
Baron, Ralf
author_facet Sachau, Juliane
Kersebaum, Dilara
Hüllemann, Philipp
Adolf, Daniela
Kabelitz, Maria
Keller, Thomas
Freynhagen, Rainer
Tölle, Thomas R.
Binder, Andreas
Baron, Ralf
author_sort Sachau, Juliane
collection PubMed
description INTRODUCTION: Patients with neuropathic pain (NP) report a higher impairment of quality of life and sleep than patients with chronic pain without neuropathic characteristics. These include somatosensory peculiarities like allodynia, a surrogate marker for central sensitization. OBJECTIVES: This study aimed to investigate the relation between symptoms of central sensitization and sleep disturbances in patients with NP. METHODS: Within this cross-sectional study, data sets of 3339 patients with chronic NP syndromes (painful diabetic polyneuropathy, n = 543; postherpetic neuralgia, n = 1480) or complex regional pain syndromes (CRPS, n = 1316) were analyzed. Neuropathic pain symptoms were assessed with the painDETECT questionnaire (PD-Q), depression with the Patient Health Questionnaire-9, and sleep impairment with items of the Medical Outcomes Study Sleep Scale in 4 subscales. The association of demographic/clinical data, somatosensory phenotype, depression, and pain intensity with sleep impairment was assessed by unadjusted Spearman correlation analyses and multivariable regression analyses. RESULTS: Sleep impairment was observed in all pain aetiologies although with some significant differences in the single sleep items. The intensity of the individual PD-Q items differed to some extent between the 3 pain entities, whereas the PD-Q sum score was similar. Thermal hyperalgesia and burning assessed by the PD-Q were significantly associated with sleep disturbance, adequacy, and quantity but not with sleep somnolence. Only depression and self-reported allodynia had a significant relation to all 4 sleep elements. CONCLUSION: Beside depression, allodynia as a surrogate marker hints to a possible impact of central sensitization on the sleep disruption of patients with NP.
format Online
Article
Text
id pubmed-10531265
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Wolters Kluwer
record_format MEDLINE/PubMed
spelling pubmed-105312652023-09-28 The association of self-reported symptoms of central sensitization and sleep disturbances in neuropathic pain Sachau, Juliane Kersebaum, Dilara Hüllemann, Philipp Adolf, Daniela Kabelitz, Maria Keller, Thomas Freynhagen, Rainer Tölle, Thomas R. Binder, Andreas Baron, Ralf Pain Rep Neuropathic INTRODUCTION: Patients with neuropathic pain (NP) report a higher impairment of quality of life and sleep than patients with chronic pain without neuropathic characteristics. These include somatosensory peculiarities like allodynia, a surrogate marker for central sensitization. OBJECTIVES: This study aimed to investigate the relation between symptoms of central sensitization and sleep disturbances in patients with NP. METHODS: Within this cross-sectional study, data sets of 3339 patients with chronic NP syndromes (painful diabetic polyneuropathy, n = 543; postherpetic neuralgia, n = 1480) or complex regional pain syndromes (CRPS, n = 1316) were analyzed. Neuropathic pain symptoms were assessed with the painDETECT questionnaire (PD-Q), depression with the Patient Health Questionnaire-9, and sleep impairment with items of the Medical Outcomes Study Sleep Scale in 4 subscales. The association of demographic/clinical data, somatosensory phenotype, depression, and pain intensity with sleep impairment was assessed by unadjusted Spearman correlation analyses and multivariable regression analyses. RESULTS: Sleep impairment was observed in all pain aetiologies although with some significant differences in the single sleep items. The intensity of the individual PD-Q items differed to some extent between the 3 pain entities, whereas the PD-Q sum score was similar. Thermal hyperalgesia and burning assessed by the PD-Q were significantly associated with sleep disturbance, adequacy, and quantity but not with sleep somnolence. Only depression and self-reported allodynia had a significant relation to all 4 sleep elements. CONCLUSION: Beside depression, allodynia as a surrogate marker hints to a possible impact of central sensitization on the sleep disruption of patients with NP. Wolters Kluwer 2023-09-26 /pmc/articles/PMC10531265/ /pubmed/37772033 http://dx.doi.org/10.1097/PR9.0000000000001098 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle Neuropathic
Sachau, Juliane
Kersebaum, Dilara
Hüllemann, Philipp
Adolf, Daniela
Kabelitz, Maria
Keller, Thomas
Freynhagen, Rainer
Tölle, Thomas R.
Binder, Andreas
Baron, Ralf
The association of self-reported symptoms of central sensitization and sleep disturbances in neuropathic pain
title The association of self-reported symptoms of central sensitization and sleep disturbances in neuropathic pain
title_full The association of self-reported symptoms of central sensitization and sleep disturbances in neuropathic pain
title_fullStr The association of self-reported symptoms of central sensitization and sleep disturbances in neuropathic pain
title_full_unstemmed The association of self-reported symptoms of central sensitization and sleep disturbances in neuropathic pain
title_short The association of self-reported symptoms of central sensitization and sleep disturbances in neuropathic pain
title_sort association of self-reported symptoms of central sensitization and sleep disturbances in neuropathic pain
topic Neuropathic
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531265/
https://www.ncbi.nlm.nih.gov/pubmed/37772033
http://dx.doi.org/10.1097/PR9.0000000000001098
work_keys_str_mv AT sachaujuliane theassociationofselfreportedsymptomsofcentralsensitizationandsleepdisturbancesinneuropathicpain
AT kersebaumdilara theassociationofselfreportedsymptomsofcentralsensitizationandsleepdisturbancesinneuropathicpain
AT hullemannphilipp theassociationofselfreportedsymptomsofcentralsensitizationandsleepdisturbancesinneuropathicpain
AT adolfdaniela theassociationofselfreportedsymptomsofcentralsensitizationandsleepdisturbancesinneuropathicpain
AT kabelitzmaria theassociationofselfreportedsymptomsofcentralsensitizationandsleepdisturbancesinneuropathicpain
AT kellerthomas theassociationofselfreportedsymptomsofcentralsensitizationandsleepdisturbancesinneuropathicpain
AT freynhagenrainer theassociationofselfreportedsymptomsofcentralsensitizationandsleepdisturbancesinneuropathicpain
AT tollethomasr theassociationofselfreportedsymptomsofcentralsensitizationandsleepdisturbancesinneuropathicpain
AT binderandreas theassociationofselfreportedsymptomsofcentralsensitizationandsleepdisturbancesinneuropathicpain
AT baronralf theassociationofselfreportedsymptomsofcentralsensitizationandsleepdisturbancesinneuropathicpain
AT sachaujuliane associationofselfreportedsymptomsofcentralsensitizationandsleepdisturbancesinneuropathicpain
AT kersebaumdilara associationofselfreportedsymptomsofcentralsensitizationandsleepdisturbancesinneuropathicpain
AT hullemannphilipp associationofselfreportedsymptomsofcentralsensitizationandsleepdisturbancesinneuropathicpain
AT adolfdaniela associationofselfreportedsymptomsofcentralsensitizationandsleepdisturbancesinneuropathicpain
AT kabelitzmaria associationofselfreportedsymptomsofcentralsensitizationandsleepdisturbancesinneuropathicpain
AT kellerthomas associationofselfreportedsymptomsofcentralsensitizationandsleepdisturbancesinneuropathicpain
AT freynhagenrainer associationofselfreportedsymptomsofcentralsensitizationandsleepdisturbancesinneuropathicpain
AT tollethomasr associationofselfreportedsymptomsofcentralsensitizationandsleepdisturbancesinneuropathicpain
AT binderandreas associationofselfreportedsymptomsofcentralsensitizationandsleepdisturbancesinneuropathicpain
AT baronralf associationofselfreportedsymptomsofcentralsensitizationandsleepdisturbancesinneuropathicpain