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Simufilam Reverses Aberrant Receptor Interactions of Filamin A in Alzheimer’s Disease

Simufilam is a novel oral drug candidate in Phase 3 clinical trials for Alzheimer’s disease (AD) dementia. This small molecule binds an altered form of filamin A (FLNA) that occurs in AD. This drug action disrupts FLNA’s aberrant linkage to the α7 nicotinic acetylcholine receptor (α7nAChR), thereby...

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Detalles Bibliográficos
Autores principales:	Wang, Hoau-Yan, Cecon, Erika, Dam, Julie, Pei, Zhe, Jockers, Ralf, Burns, Lindsay H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531384/ https://www.ncbi.nlm.nih.gov/pubmed/37762230 http://dx.doi.org/10.3390/ijms241813927

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