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Hylin-a1: A Pan-Inhibitor against Emerging and Re-Emerging Respiratory Viruses

Pandemic and epidemic outbreaks of respiratory viruses are a challenge for public health and social care system worldwide, leading to high mortality and morbidity among the human populations. In light of the limited efficacy of current vaccines and antiviral drugs against respiratory viral infection...

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Autores principales: Chianese, Annalisa, Zannella, Carla, Monti, Alessandra, Doti, Nunzianna, Sanna, Giuseppina, Manzin, Aldo, De Filippis, Anna, Galdiero, Massimiliano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531407/
https://www.ncbi.nlm.nih.gov/pubmed/37762191
http://dx.doi.org/10.3390/ijms241813888
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author Chianese, Annalisa
Zannella, Carla
Monti, Alessandra
Doti, Nunzianna
Sanna, Giuseppina
Manzin, Aldo
De Filippis, Anna
Galdiero, Massimiliano
author_facet Chianese, Annalisa
Zannella, Carla
Monti, Alessandra
Doti, Nunzianna
Sanna, Giuseppina
Manzin, Aldo
De Filippis, Anna
Galdiero, Massimiliano
author_sort Chianese, Annalisa
collection PubMed
description Pandemic and epidemic outbreaks of respiratory viruses are a challenge for public health and social care system worldwide, leading to high mortality and morbidity among the human populations. In light of the limited efficacy of current vaccines and antiviral drugs against respiratory viral infections and the emergence and re-emergence of new viruses, novel broad-spectrum antiviral drugs are needed for the prevention and treatment of these infections. Antimicrobial peptides with an antiviral effect, also known as AVPs, have already been reported as potent inhibitors of viral infections by affecting different stages of the virus lifecycle. In the present study, we analyzed the activity of the AVP Hylin-a1, secreted by the frog Hypsiboas albopunctatus, against a wide range of respiratory viruses, including the coronaviruses HCoV-229E and SARS-CoV-2, measles virus, human parainfluenza virus type 3, and influenza virus H1N1. We report a significant inhibitory effect on infectivity in all the enveloped viruses, whereas there was a lack of activity against the naked coxsackievirus B3. Considering the enormous therapeutic potential of Hylin-a1, further experiments are required to elucidate its mechanism of action and to increase its stability by modifying the native sequence.
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spelling pubmed-105314072023-09-28 Hylin-a1: A Pan-Inhibitor against Emerging and Re-Emerging Respiratory Viruses Chianese, Annalisa Zannella, Carla Monti, Alessandra Doti, Nunzianna Sanna, Giuseppina Manzin, Aldo De Filippis, Anna Galdiero, Massimiliano Int J Mol Sci Article Pandemic and epidemic outbreaks of respiratory viruses are a challenge for public health and social care system worldwide, leading to high mortality and morbidity among the human populations. In light of the limited efficacy of current vaccines and antiviral drugs against respiratory viral infections and the emergence and re-emergence of new viruses, novel broad-spectrum antiviral drugs are needed for the prevention and treatment of these infections. Antimicrobial peptides with an antiviral effect, also known as AVPs, have already been reported as potent inhibitors of viral infections by affecting different stages of the virus lifecycle. In the present study, we analyzed the activity of the AVP Hylin-a1, secreted by the frog Hypsiboas albopunctatus, against a wide range of respiratory viruses, including the coronaviruses HCoV-229E and SARS-CoV-2, measles virus, human parainfluenza virus type 3, and influenza virus H1N1. We report a significant inhibitory effect on infectivity in all the enveloped viruses, whereas there was a lack of activity against the naked coxsackievirus B3. Considering the enormous therapeutic potential of Hylin-a1, further experiments are required to elucidate its mechanism of action and to increase its stability by modifying the native sequence. MDPI 2023-09-09 /pmc/articles/PMC10531407/ /pubmed/37762191 http://dx.doi.org/10.3390/ijms241813888 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chianese, Annalisa
Zannella, Carla
Monti, Alessandra
Doti, Nunzianna
Sanna, Giuseppina
Manzin, Aldo
De Filippis, Anna
Galdiero, Massimiliano
Hylin-a1: A Pan-Inhibitor against Emerging and Re-Emerging Respiratory Viruses
title Hylin-a1: A Pan-Inhibitor against Emerging and Re-Emerging Respiratory Viruses
title_full Hylin-a1: A Pan-Inhibitor against Emerging and Re-Emerging Respiratory Viruses
title_fullStr Hylin-a1: A Pan-Inhibitor against Emerging and Re-Emerging Respiratory Viruses
title_full_unstemmed Hylin-a1: A Pan-Inhibitor against Emerging and Re-Emerging Respiratory Viruses
title_short Hylin-a1: A Pan-Inhibitor against Emerging and Re-Emerging Respiratory Viruses
title_sort hylin-a1: a pan-inhibitor against emerging and re-emerging respiratory viruses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531407/
https://www.ncbi.nlm.nih.gov/pubmed/37762191
http://dx.doi.org/10.3390/ijms241813888
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