Assessment of Apolipoprotein(a) Isoform Size Using Phenotypic and Genotypic Methods

Apolipoprotein(a) (apo(a)) is the protein component that defines lipoprotein(a) (Lp(a)) particles and is encoded by the LPA gene. The apo(a) is extremely heterogeneous in size due to the copy number variations in the kringle-IV type 2 (KIV2) domains. In this review, we aim to discuss the role of gen...

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Autores principales: Fogacci, Federica, Di Micoli, Valentina, Avagimyan, Ashot, Giovannini, Marina, Imbalzano, Egidio, Cicero, Arrigo F. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531419/
https://www.ncbi.nlm.nih.gov/pubmed/37762189
http://dx.doi.org/10.3390/ijms241813886
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author Fogacci, Federica
Di Micoli, Valentina
Avagimyan, Ashot
Giovannini, Marina
Imbalzano, Egidio
Cicero, Arrigo F. G.
author_facet Fogacci, Federica
Di Micoli, Valentina
Avagimyan, Ashot
Giovannini, Marina
Imbalzano, Egidio
Cicero, Arrigo F. G.
author_sort Fogacci, Federica
collection PubMed
description Apolipoprotein(a) (apo(a)) is the protein component that defines lipoprotein(a) (Lp(a)) particles and is encoded by the LPA gene. The apo(a) is extremely heterogeneous in size due to the copy number variations in the kringle-IV type 2 (KIV2) domains. In this review, we aim to discuss the role of genetics in establishing Lp(a) as a risk factor for coronary heart disease (CHD) by examining a series of molecular biology techniques aimed at identifying the best strategy for a possible application in clinical research and practice, according to the current gold standard.
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spelling pubmed-105314192023-09-28 Assessment of Apolipoprotein(a) Isoform Size Using Phenotypic and Genotypic Methods Fogacci, Federica Di Micoli, Valentina Avagimyan, Ashot Giovannini, Marina Imbalzano, Egidio Cicero, Arrigo F. G. Int J Mol Sci Review Apolipoprotein(a) (apo(a)) is the protein component that defines lipoprotein(a) (Lp(a)) particles and is encoded by the LPA gene. The apo(a) is extremely heterogeneous in size due to the copy number variations in the kringle-IV type 2 (KIV2) domains. In this review, we aim to discuss the role of genetics in establishing Lp(a) as a risk factor for coronary heart disease (CHD) by examining a series of molecular biology techniques aimed at identifying the best strategy for a possible application in clinical research and practice, according to the current gold standard. MDPI 2023-09-09 /pmc/articles/PMC10531419/ /pubmed/37762189 http://dx.doi.org/10.3390/ijms241813886 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fogacci, Federica
Di Micoli, Valentina
Avagimyan, Ashot
Giovannini, Marina
Imbalzano, Egidio
Cicero, Arrigo F. G.
Assessment of Apolipoprotein(a) Isoform Size Using Phenotypic and Genotypic Methods
title Assessment of Apolipoprotein(a) Isoform Size Using Phenotypic and Genotypic Methods
title_full Assessment of Apolipoprotein(a) Isoform Size Using Phenotypic and Genotypic Methods
title_fullStr Assessment of Apolipoprotein(a) Isoform Size Using Phenotypic and Genotypic Methods
title_full_unstemmed Assessment of Apolipoprotein(a) Isoform Size Using Phenotypic and Genotypic Methods
title_short Assessment of Apolipoprotein(a) Isoform Size Using Phenotypic and Genotypic Methods
title_sort assessment of apolipoprotein(a) isoform size using phenotypic and genotypic methods
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531419/
https://www.ncbi.nlm.nih.gov/pubmed/37762189
http://dx.doi.org/10.3390/ijms241813886
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