Cargando…

Exercise Does Not Independently Improve Histological Outcomes in Biopsy-Proven Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis

Introduction: The independent effect of exercise on liver histology in non-alcoholic fatty liver disease (NAFLD) remains unclear. As such, we conducted a systematic review and meta-analysis of the effect of exercise alone on histological endpoints in biopsy-proven NAFLD. Materials and Methods: A sys...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, George, Banini, Bubu A., Do, Albert, Gunderson, Craig, Zaman, Saif, Lim, Joseph K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531443/
https://www.ncbi.nlm.nih.gov/pubmed/37761951
http://dx.doi.org/10.3390/genes14091811
_version_ 1785111719847133184
author Chen, George
Banini, Bubu A.
Do, Albert
Gunderson, Craig
Zaman, Saif
Lim, Joseph K.
author_facet Chen, George
Banini, Bubu A.
Do, Albert
Gunderson, Craig
Zaman, Saif
Lim, Joseph K.
author_sort Chen, George
collection PubMed
description Introduction: The independent effect of exercise on liver histology in non-alcoholic fatty liver disease (NAFLD) remains unclear. As such, we conducted a systematic review and meta-analysis of the effect of exercise alone on histological endpoints in biopsy-proven NAFLD. Materials and Methods: A systematic literature search was conducted to include controlled clinical trials investigating the effect of exercise alone on liver histology in biopsy-proven NAFLD. Meta-analysis was conducted for histological outcomes with available data from a minimum of three studies. Pooled estimates of the effect of exercise on histological endpoints were calculated using random-effects models. Results: We identified three controlled clinical trials that assessed the independent effect of exercise on histological outcomes in patients with biopsy-proven NAFLD. The studies consisted of 72 total participants, including 40 subjects in the exercise intervention and 32 individuals in the comparison group. Meta-analysis showed that exercise did not significantly improve Brunt grade, NAFLD activity score, and fibrosis in NAFLD. Discussion: Exercise alone may not lead to significant histopathological improvement in NAFLD. Future well-powered randomized controlled trials are needed to better characterize the impact of exercise on histological outcomes and clinical endpoints.
format Online
Article
Text
id pubmed-10531443
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-105314432023-09-28 Exercise Does Not Independently Improve Histological Outcomes in Biopsy-Proven Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis Chen, George Banini, Bubu A. Do, Albert Gunderson, Craig Zaman, Saif Lim, Joseph K. Genes (Basel) Review Introduction: The independent effect of exercise on liver histology in non-alcoholic fatty liver disease (NAFLD) remains unclear. As such, we conducted a systematic review and meta-analysis of the effect of exercise alone on histological endpoints in biopsy-proven NAFLD. Materials and Methods: A systematic literature search was conducted to include controlled clinical trials investigating the effect of exercise alone on liver histology in biopsy-proven NAFLD. Meta-analysis was conducted for histological outcomes with available data from a minimum of three studies. Pooled estimates of the effect of exercise on histological endpoints were calculated using random-effects models. Results: We identified three controlled clinical trials that assessed the independent effect of exercise on histological outcomes in patients with biopsy-proven NAFLD. The studies consisted of 72 total participants, including 40 subjects in the exercise intervention and 32 individuals in the comparison group. Meta-analysis showed that exercise did not significantly improve Brunt grade, NAFLD activity score, and fibrosis in NAFLD. Discussion: Exercise alone may not lead to significant histopathological improvement in NAFLD. Future well-powered randomized controlled trials are needed to better characterize the impact of exercise on histological outcomes and clinical endpoints. MDPI 2023-09-17 /pmc/articles/PMC10531443/ /pubmed/37761951 http://dx.doi.org/10.3390/genes14091811 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chen, George
Banini, Bubu A.
Do, Albert
Gunderson, Craig
Zaman, Saif
Lim, Joseph K.
Exercise Does Not Independently Improve Histological Outcomes in Biopsy-Proven Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
title Exercise Does Not Independently Improve Histological Outcomes in Biopsy-Proven Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
title_full Exercise Does Not Independently Improve Histological Outcomes in Biopsy-Proven Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
title_fullStr Exercise Does Not Independently Improve Histological Outcomes in Biopsy-Proven Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
title_full_unstemmed Exercise Does Not Independently Improve Histological Outcomes in Biopsy-Proven Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
title_short Exercise Does Not Independently Improve Histological Outcomes in Biopsy-Proven Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
title_sort exercise does not independently improve histological outcomes in biopsy-proven non-alcoholic fatty liver disease: a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531443/
https://www.ncbi.nlm.nih.gov/pubmed/37761951
http://dx.doi.org/10.3390/genes14091811
work_keys_str_mv AT chengeorge exercisedoesnotindependentlyimprovehistologicaloutcomesinbiopsyprovennonalcoholicfattyliverdiseaseasystematicreviewandmetaanalysis
AT baninibubua exercisedoesnotindependentlyimprovehistologicaloutcomesinbiopsyprovennonalcoholicfattyliverdiseaseasystematicreviewandmetaanalysis
AT doalbert exercisedoesnotindependentlyimprovehistologicaloutcomesinbiopsyprovennonalcoholicfattyliverdiseaseasystematicreviewandmetaanalysis
AT gundersoncraig exercisedoesnotindependentlyimprovehistologicaloutcomesinbiopsyprovennonalcoholicfattyliverdiseaseasystematicreviewandmetaanalysis
AT zamansaif exercisedoesnotindependentlyimprovehistologicaloutcomesinbiopsyprovennonalcoholicfattyliverdiseaseasystematicreviewandmetaanalysis
AT limjosephk exercisedoesnotindependentlyimprovehistologicaloutcomesinbiopsyprovennonalcoholicfattyliverdiseaseasystematicreviewandmetaanalysis