In Silico Mixed Ligand/Structure-Based Design of New CDK-1/PARP-1 Dual Inhibitors as Anti-Breast Cancer Agents

CDK-1 and PARP-1 play crucial roles in breast cancer progression. Compounds acting as CDK-1 and/or PARP-1 inhibitors can induct cell death in breast cancer with a selective synthetic lethality mechanism. A mixed treatment by means of CDK-1 and PARP-1 inhibitors resulted in radical breast cancer cell...

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Detalles Bibliográficos
Autores principales: Bono, Alessia, La Monica, Gabriele, Alamia, Federica, Mingoia, Francesco, Gentile, Carla, Peri, Daniele, Lauria, Antonino, Martorana, Annamaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531453/
https://www.ncbi.nlm.nih.gov/pubmed/37762072
http://dx.doi.org/10.3390/ijms241813769

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531453/
https://www.ncbi.nlm.nih.gov/pubmed/37762072
http://dx.doi.org/10.3390/ijms241813769

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