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“Troponinosis”, the Cardiologist’s Curse—When Clinic–Laboratory Interaction Unveils the Mystery: A Case Report

Cardiac troponins are key diagnostic and prognostic biomarkers in acute myocardial infarction and, more generally, for the detection of myocardial injury. Since the introduction of the first immunochemistry methods, there has been a remarkable evolution in analytical performance, especially concerni...

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Autores principales: Bosi, Davide, Canovi, Simone, Pennacchioni, Andrea, Demola, Pierluigi, Corradini, Mattia, Guiducci, Vincenzo, Colla, Rossana, Navazio, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531523/
https://www.ncbi.nlm.nih.gov/pubmed/37754807
http://dx.doi.org/10.3390/jcdd10090378
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author Bosi, Davide
Canovi, Simone
Pennacchioni, Andrea
Demola, Pierluigi
Corradini, Mattia
Guiducci, Vincenzo
Colla, Rossana
Navazio, Alessandro
author_facet Bosi, Davide
Canovi, Simone
Pennacchioni, Andrea
Demola, Pierluigi
Corradini, Mattia
Guiducci, Vincenzo
Colla, Rossana
Navazio, Alessandro
author_sort Bosi, Davide
collection PubMed
description Cardiac troponins are key diagnostic and prognostic biomarkers in acute myocardial infarction and, more generally, for the detection of myocardial injury. Since the introduction of the first immunochemistry methods, there has been a remarkable evolution in analytical performance, especially concerning a progressive improvement in sensitivity. However, the measurement of circulating troponins remains rarely susceptible to analytical interferences. We report a case of persistently elevated troponin I concentrations in a patient with known ischemic heart disease, which almost led to unnecessary diagnostic–therapeutic interventions. A prompt laboratory consultation by the cardiologist ultimately led to the identification of an analytical interference due to troponin macrocomplexes (macrotroponin) causing elevated troponin values in the absence of a clinical presentation compatible with myocardial damage.
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spelling pubmed-105315232023-09-28 “Troponinosis”, the Cardiologist’s Curse—When Clinic–Laboratory Interaction Unveils the Mystery: A Case Report Bosi, Davide Canovi, Simone Pennacchioni, Andrea Demola, Pierluigi Corradini, Mattia Guiducci, Vincenzo Colla, Rossana Navazio, Alessandro J Cardiovasc Dev Dis Case Report Cardiac troponins are key diagnostic and prognostic biomarkers in acute myocardial infarction and, more generally, for the detection of myocardial injury. Since the introduction of the first immunochemistry methods, there has been a remarkable evolution in analytical performance, especially concerning a progressive improvement in sensitivity. However, the measurement of circulating troponins remains rarely susceptible to analytical interferences. We report a case of persistently elevated troponin I concentrations in a patient with known ischemic heart disease, which almost led to unnecessary diagnostic–therapeutic interventions. A prompt laboratory consultation by the cardiologist ultimately led to the identification of an analytical interference due to troponin macrocomplexes (macrotroponin) causing elevated troponin values in the absence of a clinical presentation compatible with myocardial damage. MDPI 2023-09-03 /pmc/articles/PMC10531523/ /pubmed/37754807 http://dx.doi.org/10.3390/jcdd10090378 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Bosi, Davide
Canovi, Simone
Pennacchioni, Andrea
Demola, Pierluigi
Corradini, Mattia
Guiducci, Vincenzo
Colla, Rossana
Navazio, Alessandro
“Troponinosis”, the Cardiologist’s Curse—When Clinic–Laboratory Interaction Unveils the Mystery: A Case Report
title “Troponinosis”, the Cardiologist’s Curse—When Clinic–Laboratory Interaction Unveils the Mystery: A Case Report
title_full “Troponinosis”, the Cardiologist’s Curse—When Clinic–Laboratory Interaction Unveils the Mystery: A Case Report
title_fullStr “Troponinosis”, the Cardiologist’s Curse—When Clinic–Laboratory Interaction Unveils the Mystery: A Case Report
title_full_unstemmed “Troponinosis”, the Cardiologist’s Curse—When Clinic–Laboratory Interaction Unveils the Mystery: A Case Report
title_short “Troponinosis”, the Cardiologist’s Curse—When Clinic–Laboratory Interaction Unveils the Mystery: A Case Report
title_sort “troponinosis”, the cardiologist’s curse—when clinic–laboratory interaction unveils the mystery: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531523/
https://www.ncbi.nlm.nih.gov/pubmed/37754807
http://dx.doi.org/10.3390/jcdd10090378
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