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“Troponinosis”, the Cardiologist’s Curse—When Clinic–Laboratory Interaction Unveils the Mystery: A Case Report
Cardiac troponins are key diagnostic and prognostic biomarkers in acute myocardial infarction and, more generally, for the detection of myocardial injury. Since the introduction of the first immunochemistry methods, there has been a remarkable evolution in analytical performance, especially concerni...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531523/ https://www.ncbi.nlm.nih.gov/pubmed/37754807 http://dx.doi.org/10.3390/jcdd10090378 |
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author | Bosi, Davide Canovi, Simone Pennacchioni, Andrea Demola, Pierluigi Corradini, Mattia Guiducci, Vincenzo Colla, Rossana Navazio, Alessandro |
author_facet | Bosi, Davide Canovi, Simone Pennacchioni, Andrea Demola, Pierluigi Corradini, Mattia Guiducci, Vincenzo Colla, Rossana Navazio, Alessandro |
author_sort | Bosi, Davide |
collection | PubMed |
description | Cardiac troponins are key diagnostic and prognostic biomarkers in acute myocardial infarction and, more generally, for the detection of myocardial injury. Since the introduction of the first immunochemistry methods, there has been a remarkable evolution in analytical performance, especially concerning a progressive improvement in sensitivity. However, the measurement of circulating troponins remains rarely susceptible to analytical interferences. We report a case of persistently elevated troponin I concentrations in a patient with known ischemic heart disease, which almost led to unnecessary diagnostic–therapeutic interventions. A prompt laboratory consultation by the cardiologist ultimately led to the identification of an analytical interference due to troponin macrocomplexes (macrotroponin) causing elevated troponin values in the absence of a clinical presentation compatible with myocardial damage. |
format | Online Article Text |
id | pubmed-10531523 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105315232023-09-28 “Troponinosis”, the Cardiologist’s Curse—When Clinic–Laboratory Interaction Unveils the Mystery: A Case Report Bosi, Davide Canovi, Simone Pennacchioni, Andrea Demola, Pierluigi Corradini, Mattia Guiducci, Vincenzo Colla, Rossana Navazio, Alessandro J Cardiovasc Dev Dis Case Report Cardiac troponins are key diagnostic and prognostic biomarkers in acute myocardial infarction and, more generally, for the detection of myocardial injury. Since the introduction of the first immunochemistry methods, there has been a remarkable evolution in analytical performance, especially concerning a progressive improvement in sensitivity. However, the measurement of circulating troponins remains rarely susceptible to analytical interferences. We report a case of persistently elevated troponin I concentrations in a patient with known ischemic heart disease, which almost led to unnecessary diagnostic–therapeutic interventions. A prompt laboratory consultation by the cardiologist ultimately led to the identification of an analytical interference due to troponin macrocomplexes (macrotroponin) causing elevated troponin values in the absence of a clinical presentation compatible with myocardial damage. MDPI 2023-09-03 /pmc/articles/PMC10531523/ /pubmed/37754807 http://dx.doi.org/10.3390/jcdd10090378 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Bosi, Davide Canovi, Simone Pennacchioni, Andrea Demola, Pierluigi Corradini, Mattia Guiducci, Vincenzo Colla, Rossana Navazio, Alessandro “Troponinosis”, the Cardiologist’s Curse—When Clinic–Laboratory Interaction Unveils the Mystery: A Case Report |
title | “Troponinosis”, the Cardiologist’s Curse—When Clinic–Laboratory Interaction Unveils the Mystery: A Case Report |
title_full | “Troponinosis”, the Cardiologist’s Curse—When Clinic–Laboratory Interaction Unveils the Mystery: A Case Report |
title_fullStr | “Troponinosis”, the Cardiologist’s Curse—When Clinic–Laboratory Interaction Unveils the Mystery: A Case Report |
title_full_unstemmed | “Troponinosis”, the Cardiologist’s Curse—When Clinic–Laboratory Interaction Unveils the Mystery: A Case Report |
title_short | “Troponinosis”, the Cardiologist’s Curse—When Clinic–Laboratory Interaction Unveils the Mystery: A Case Report |
title_sort | “troponinosis”, the cardiologist’s curse—when clinic–laboratory interaction unveils the mystery: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531523/ https://www.ncbi.nlm.nih.gov/pubmed/37754807 http://dx.doi.org/10.3390/jcdd10090378 |
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