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Nonspecific Gastrointestinal Symptoms as the First Sign of Ganglioneuroblastoma Intermixed—Case Report and Literature Review

Nonspecific gastrointestinal symptoms remain a problem for pediatricians because, out of a thousand trivial cases, there are rare diseases that require in-depth diagnostics and extensive knowledge to identify them. These complaints may be caused by a neoplastic process. We present the case of a 5-ye...

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Autores principales: Lipiński, Łukasz, Lipińska, Justyna, Kowalczuk, Maria, Kopeć, Izabela, Woźniak, Magdalena Maria, Mitek-Palusińska, Joanna, Mitura-Lesiuk, Małgorzata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531539/
https://www.ncbi.nlm.nih.gov/pubmed/37763032
http://dx.doi.org/10.3390/jcm12186092
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author Lipiński, Łukasz
Lipińska, Justyna
Kowalczuk, Maria
Kopeć, Izabela
Woźniak, Magdalena Maria
Mitek-Palusińska, Joanna
Mitura-Lesiuk, Małgorzata
author_facet Lipiński, Łukasz
Lipińska, Justyna
Kowalczuk, Maria
Kopeć, Izabela
Woźniak, Magdalena Maria
Mitek-Palusińska, Joanna
Mitura-Lesiuk, Małgorzata
author_sort Lipiński, Łukasz
collection PubMed
description Nonspecific gastrointestinal symptoms remain a problem for pediatricians because, out of a thousand trivial cases, there are rare diseases that require in-depth diagnostics and extensive knowledge to identify them. These complaints may be caused by a neoplastic process. We present the case of a 5-year-old boy whose diagnostic pathway lasted about 3 months. He was admitted to hospital due to severe abdominal pain. Physical examination revealed a bloated, hard, and painful abdomen. In the standing X-ray, the features of intestinal obstruction were visualized. An ultrasound examination showed a possible malignant lesion in the location of the left adrenal gland. After the surgical removal of the pathological mass and histopathological examination, the diagnosis of ganglioneuroblastoma intermixed was made. This tumor, along with neuroblastoma, ganglioneuroma, and ganglioneuroblastoma nodular, belongs to neuroblastic tumors (NTs), which originate from primitive cells of the sympathetic nervous system. NTs are quite rare, but they are still the majority of extracranial solid tumors in children, and their symptoms often appear relatively late when the neoplastic process is already advanced. The purpose of this review is to present current information about ganglioneuroblastoma, with a special emphasis on nonspecific gastrointestinal symptoms as first sign of this tumor and its diagnostics.
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spelling pubmed-105315392023-09-28 Nonspecific Gastrointestinal Symptoms as the First Sign of Ganglioneuroblastoma Intermixed—Case Report and Literature Review Lipiński, Łukasz Lipińska, Justyna Kowalczuk, Maria Kopeć, Izabela Woźniak, Magdalena Maria Mitek-Palusińska, Joanna Mitura-Lesiuk, Małgorzata J Clin Med Review Nonspecific gastrointestinal symptoms remain a problem for pediatricians because, out of a thousand trivial cases, there are rare diseases that require in-depth diagnostics and extensive knowledge to identify them. These complaints may be caused by a neoplastic process. We present the case of a 5-year-old boy whose diagnostic pathway lasted about 3 months. He was admitted to hospital due to severe abdominal pain. Physical examination revealed a bloated, hard, and painful abdomen. In the standing X-ray, the features of intestinal obstruction were visualized. An ultrasound examination showed a possible malignant lesion in the location of the left adrenal gland. After the surgical removal of the pathological mass and histopathological examination, the diagnosis of ganglioneuroblastoma intermixed was made. This tumor, along with neuroblastoma, ganglioneuroma, and ganglioneuroblastoma nodular, belongs to neuroblastic tumors (NTs), which originate from primitive cells of the sympathetic nervous system. NTs are quite rare, but they are still the majority of extracranial solid tumors in children, and their symptoms often appear relatively late when the neoplastic process is already advanced. The purpose of this review is to present current information about ganglioneuroblastoma, with a special emphasis on nonspecific gastrointestinal symptoms as first sign of this tumor and its diagnostics. MDPI 2023-09-21 /pmc/articles/PMC10531539/ /pubmed/37763032 http://dx.doi.org/10.3390/jcm12186092 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lipiński, Łukasz
Lipińska, Justyna
Kowalczuk, Maria
Kopeć, Izabela
Woźniak, Magdalena Maria
Mitek-Palusińska, Joanna
Mitura-Lesiuk, Małgorzata
Nonspecific Gastrointestinal Symptoms as the First Sign of Ganglioneuroblastoma Intermixed—Case Report and Literature Review
title Nonspecific Gastrointestinal Symptoms as the First Sign of Ganglioneuroblastoma Intermixed—Case Report and Literature Review
title_full Nonspecific Gastrointestinal Symptoms as the First Sign of Ganglioneuroblastoma Intermixed—Case Report and Literature Review
title_fullStr Nonspecific Gastrointestinal Symptoms as the First Sign of Ganglioneuroblastoma Intermixed—Case Report and Literature Review
title_full_unstemmed Nonspecific Gastrointestinal Symptoms as the First Sign of Ganglioneuroblastoma Intermixed—Case Report and Literature Review
title_short Nonspecific Gastrointestinal Symptoms as the First Sign of Ganglioneuroblastoma Intermixed—Case Report and Literature Review
title_sort nonspecific gastrointestinal symptoms as the first sign of ganglioneuroblastoma intermixed—case report and literature review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531539/
https://www.ncbi.nlm.nih.gov/pubmed/37763032
http://dx.doi.org/10.3390/jcm12186092
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