Cargando…

Hemoadsorption Using CytoSorb(®) in Patients with Infective Endocarditis: A German-Based Budget Impact Analysis

A considerable number of infective endocarditis (IE) patients require cardiac surgery with an increased risk for postoperative sepsis. Intraoperative hemoadsorption may diminish the risk of postoperative hyperinflammation with potential economic implications for intensive care unit (ICU) occupation....

Descripción completa

Detalles Bibliográficos
Autores principales: Rao, Cristina, Preissing, Franziska, Thielmann, Matthias, Wendt, Daniel, Haidari, Zaki, Kalisnik, Jurij Matija, Daake, Lothar, Traeger, Karl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531588/
https://www.ncbi.nlm.nih.gov/pubmed/37754795
http://dx.doi.org/10.3390/jcdd10090366
_version_ 1785111754554998784
author Rao, Cristina
Preissing, Franziska
Thielmann, Matthias
Wendt, Daniel
Haidari, Zaki
Kalisnik, Jurij Matija
Daake, Lothar
Traeger, Karl
author_facet Rao, Cristina
Preissing, Franziska
Thielmann, Matthias
Wendt, Daniel
Haidari, Zaki
Kalisnik, Jurij Matija
Daake, Lothar
Traeger, Karl
author_sort Rao, Cristina
collection PubMed
description A considerable number of infective endocarditis (IE) patients require cardiac surgery with an increased risk for postoperative sepsis. Intraoperative hemoadsorption may diminish the risk of postoperative hyperinflammation with potential economic implications for intensive care unit (ICU) occupation. The present study aimed to theoretically investigate the budget impact of a reduced length of ICU stay in IE patients treated with intraoperative hemoadsorption in the German healthcare system. Data on ICU occupation were extrapolated from a retrospective study on IE patients treated with hemoadsorption. An Excel-based budget impact model was developed to simulate the patient course over the ICU stay. A base-case scenario without therapy reimbursement and a scenario with full therapy reimbursement were explored. The annual eligible German IE patient population was derived from official German Diagnostic-Related Group (DRG) volume data. One-way deterministic sensitivity analysis and multivariate analysis were performed to evaluate the uncertainty over the model results. The use of intraoperative hemoadsorption resulted in EUR 2298 being saved per patient in the base-case scenario without therapy reimbursement. The savings increased to EUR 3804 per patient in the case of full device-specific reimbursement. Deterministic and probabilistic sensitivity analyses confirmed the robustness of savings, with a probability of savings of 87% and 99% in the base-case and full reimbursement scenario, respectively. Intraoperative hemoadsorption in IE patients might have relevant economic benefits related to reduced ICU stays, resulting in improved resource use. Further evaluations in larger prospective cohorts are warranted.
format Online
Article
Text
id pubmed-10531588
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-105315882023-09-28 Hemoadsorption Using CytoSorb(®) in Patients with Infective Endocarditis: A German-Based Budget Impact Analysis Rao, Cristina Preissing, Franziska Thielmann, Matthias Wendt, Daniel Haidari, Zaki Kalisnik, Jurij Matija Daake, Lothar Traeger, Karl J Cardiovasc Dev Dis Article A considerable number of infective endocarditis (IE) patients require cardiac surgery with an increased risk for postoperative sepsis. Intraoperative hemoadsorption may diminish the risk of postoperative hyperinflammation with potential economic implications for intensive care unit (ICU) occupation. The present study aimed to theoretically investigate the budget impact of a reduced length of ICU stay in IE patients treated with intraoperative hemoadsorption in the German healthcare system. Data on ICU occupation were extrapolated from a retrospective study on IE patients treated with hemoadsorption. An Excel-based budget impact model was developed to simulate the patient course over the ICU stay. A base-case scenario without therapy reimbursement and a scenario with full therapy reimbursement were explored. The annual eligible German IE patient population was derived from official German Diagnostic-Related Group (DRG) volume data. One-way deterministic sensitivity analysis and multivariate analysis were performed to evaluate the uncertainty over the model results. The use of intraoperative hemoadsorption resulted in EUR 2298 being saved per patient in the base-case scenario without therapy reimbursement. The savings increased to EUR 3804 per patient in the case of full device-specific reimbursement. Deterministic and probabilistic sensitivity analyses confirmed the robustness of savings, with a probability of savings of 87% and 99% in the base-case and full reimbursement scenario, respectively. Intraoperative hemoadsorption in IE patients might have relevant economic benefits related to reduced ICU stays, resulting in improved resource use. Further evaluations in larger prospective cohorts are warranted. MDPI 2023-08-26 /pmc/articles/PMC10531588/ /pubmed/37754795 http://dx.doi.org/10.3390/jcdd10090366 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rao, Cristina
Preissing, Franziska
Thielmann, Matthias
Wendt, Daniel
Haidari, Zaki
Kalisnik, Jurij Matija
Daake, Lothar
Traeger, Karl
Hemoadsorption Using CytoSorb(®) in Patients with Infective Endocarditis: A German-Based Budget Impact Analysis
title Hemoadsorption Using CytoSorb(®) in Patients with Infective Endocarditis: A German-Based Budget Impact Analysis
title_full Hemoadsorption Using CytoSorb(®) in Patients with Infective Endocarditis: A German-Based Budget Impact Analysis
title_fullStr Hemoadsorption Using CytoSorb(®) in Patients with Infective Endocarditis: A German-Based Budget Impact Analysis
title_full_unstemmed Hemoadsorption Using CytoSorb(®) in Patients with Infective Endocarditis: A German-Based Budget Impact Analysis
title_short Hemoadsorption Using CytoSorb(®) in Patients with Infective Endocarditis: A German-Based Budget Impact Analysis
title_sort hemoadsorption using cytosorb(®) in patients with infective endocarditis: a german-based budget impact analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531588/
https://www.ncbi.nlm.nih.gov/pubmed/37754795
http://dx.doi.org/10.3390/jcdd10090366
work_keys_str_mv AT raocristina hemoadsorptionusingcytosorbinpatientswithinfectiveendocarditisagermanbasedbudgetimpactanalysis
AT preissingfranziska hemoadsorptionusingcytosorbinpatientswithinfectiveendocarditisagermanbasedbudgetimpactanalysis
AT thielmannmatthias hemoadsorptionusingcytosorbinpatientswithinfectiveendocarditisagermanbasedbudgetimpactanalysis
AT wendtdaniel hemoadsorptionusingcytosorbinpatientswithinfectiveendocarditisagermanbasedbudgetimpactanalysis
AT haidarizaki hemoadsorptionusingcytosorbinpatientswithinfectiveendocarditisagermanbasedbudgetimpactanalysis
AT kalisnikjurijmatija hemoadsorptionusingcytosorbinpatientswithinfectiveendocarditisagermanbasedbudgetimpactanalysis
AT daakelothar hemoadsorptionusingcytosorbinpatientswithinfectiveendocarditisagermanbasedbudgetimpactanalysis
AT traegerkarl hemoadsorptionusingcytosorbinpatientswithinfectiveendocarditisagermanbasedbudgetimpactanalysis