Cargando…
Emerging Immunotherapy Approaches for Treating Prostate Cancer
Immunotherapy has emerged as an important approach for cancer treatment, but its clinical efficacy has been limited in prostate cancer compared to other malignancies. This review summarizes key immunotherapy strategies under evaluation for prostate cancer, including immune checkpoint inhibitors, bis...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531627/ https://www.ncbi.nlm.nih.gov/pubmed/37762648 http://dx.doi.org/10.3390/ijms241814347 |
_version_ | 1785111763695435776 |
---|---|
author | Meng, Lingbin Yang, Yuanquan Mortazavi, Amir Zhang, Jingsong |
author_facet | Meng, Lingbin Yang, Yuanquan Mortazavi, Amir Zhang, Jingsong |
author_sort | Meng, Lingbin |
collection | PubMed |
description | Immunotherapy has emerged as an important approach for cancer treatment, but its clinical efficacy has been limited in prostate cancer compared to other malignancies. This review summarizes key immunotherapy strategies under evaluation for prostate cancer, including immune checkpoint inhibitors, bispecific T cell-engaging antibodies, chimeric antigen receptor (CAR) T cells, therapeutic vaccines, and cytokines. For each modality, the rationale stemming from preclinical studies is discussed along with outcomes from completed clinical trials and strategies to improve clinical efficacy that are being tested in ongoing clinical trials. Imperative endeavors include biomarker discovery for patient selection, deciphering resistance mechanisms, refining cellular therapies such as CAR T cells, and early-stage intervention were reviewed. These ongoing efforts instill optimism that immunotherapy may eventually deliver significant clinical benefits and expand treatment options for patients with advanced prostate cancer. |
format | Online Article Text |
id | pubmed-10531627 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105316272023-09-28 Emerging Immunotherapy Approaches for Treating Prostate Cancer Meng, Lingbin Yang, Yuanquan Mortazavi, Amir Zhang, Jingsong Int J Mol Sci Review Immunotherapy has emerged as an important approach for cancer treatment, but its clinical efficacy has been limited in prostate cancer compared to other malignancies. This review summarizes key immunotherapy strategies under evaluation for prostate cancer, including immune checkpoint inhibitors, bispecific T cell-engaging antibodies, chimeric antigen receptor (CAR) T cells, therapeutic vaccines, and cytokines. For each modality, the rationale stemming from preclinical studies is discussed along with outcomes from completed clinical trials and strategies to improve clinical efficacy that are being tested in ongoing clinical trials. Imperative endeavors include biomarker discovery for patient selection, deciphering resistance mechanisms, refining cellular therapies such as CAR T cells, and early-stage intervention were reviewed. These ongoing efforts instill optimism that immunotherapy may eventually deliver significant clinical benefits and expand treatment options for patients with advanced prostate cancer. MDPI 2023-09-20 /pmc/articles/PMC10531627/ /pubmed/37762648 http://dx.doi.org/10.3390/ijms241814347 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Meng, Lingbin Yang, Yuanquan Mortazavi, Amir Zhang, Jingsong Emerging Immunotherapy Approaches for Treating Prostate Cancer |
title | Emerging Immunotherapy Approaches for Treating Prostate Cancer |
title_full | Emerging Immunotherapy Approaches for Treating Prostate Cancer |
title_fullStr | Emerging Immunotherapy Approaches for Treating Prostate Cancer |
title_full_unstemmed | Emerging Immunotherapy Approaches for Treating Prostate Cancer |
title_short | Emerging Immunotherapy Approaches for Treating Prostate Cancer |
title_sort | emerging immunotherapy approaches for treating prostate cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531627/ https://www.ncbi.nlm.nih.gov/pubmed/37762648 http://dx.doi.org/10.3390/ijms241814347 |
work_keys_str_mv | AT menglingbin emergingimmunotherapyapproachesfortreatingprostatecancer AT yangyuanquan emergingimmunotherapyapproachesfortreatingprostatecancer AT mortazaviamir emergingimmunotherapyapproachesfortreatingprostatecancer AT zhangjingsong emergingimmunotherapyapproachesfortreatingprostatecancer |