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Emerging Immunotherapy Approaches for Treating Prostate Cancer

Immunotherapy has emerged as an important approach for cancer treatment, but its clinical efficacy has been limited in prostate cancer compared to other malignancies. This review summarizes key immunotherapy strategies under evaluation for prostate cancer, including immune checkpoint inhibitors, bis...

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Detalles Bibliográficos
Autores principales: Meng, Lingbin, Yang, Yuanquan, Mortazavi, Amir, Zhang, Jingsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531627/
https://www.ncbi.nlm.nih.gov/pubmed/37762648
http://dx.doi.org/10.3390/ijms241814347
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author Meng, Lingbin
Yang, Yuanquan
Mortazavi, Amir
Zhang, Jingsong
author_facet Meng, Lingbin
Yang, Yuanquan
Mortazavi, Amir
Zhang, Jingsong
author_sort Meng, Lingbin
collection PubMed
description Immunotherapy has emerged as an important approach for cancer treatment, but its clinical efficacy has been limited in prostate cancer compared to other malignancies. This review summarizes key immunotherapy strategies under evaluation for prostate cancer, including immune checkpoint inhibitors, bispecific T cell-engaging antibodies, chimeric antigen receptor (CAR) T cells, therapeutic vaccines, and cytokines. For each modality, the rationale stemming from preclinical studies is discussed along with outcomes from completed clinical trials and strategies to improve clinical efficacy that are being tested in ongoing clinical trials. Imperative endeavors include biomarker discovery for patient selection, deciphering resistance mechanisms, refining cellular therapies such as CAR T cells, and early-stage intervention were reviewed. These ongoing efforts instill optimism that immunotherapy may eventually deliver significant clinical benefits and expand treatment options for patients with advanced prostate cancer.
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spelling pubmed-105316272023-09-28 Emerging Immunotherapy Approaches for Treating Prostate Cancer Meng, Lingbin Yang, Yuanquan Mortazavi, Amir Zhang, Jingsong Int J Mol Sci Review Immunotherapy has emerged as an important approach for cancer treatment, but its clinical efficacy has been limited in prostate cancer compared to other malignancies. This review summarizes key immunotherapy strategies under evaluation for prostate cancer, including immune checkpoint inhibitors, bispecific T cell-engaging antibodies, chimeric antigen receptor (CAR) T cells, therapeutic vaccines, and cytokines. For each modality, the rationale stemming from preclinical studies is discussed along with outcomes from completed clinical trials and strategies to improve clinical efficacy that are being tested in ongoing clinical trials. Imperative endeavors include biomarker discovery for patient selection, deciphering resistance mechanisms, refining cellular therapies such as CAR T cells, and early-stage intervention were reviewed. These ongoing efforts instill optimism that immunotherapy may eventually deliver significant clinical benefits and expand treatment options for patients with advanced prostate cancer. MDPI 2023-09-20 /pmc/articles/PMC10531627/ /pubmed/37762648 http://dx.doi.org/10.3390/ijms241814347 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Meng, Lingbin
Yang, Yuanquan
Mortazavi, Amir
Zhang, Jingsong
Emerging Immunotherapy Approaches for Treating Prostate Cancer
title Emerging Immunotherapy Approaches for Treating Prostate Cancer
title_full Emerging Immunotherapy Approaches for Treating Prostate Cancer
title_fullStr Emerging Immunotherapy Approaches for Treating Prostate Cancer
title_full_unstemmed Emerging Immunotherapy Approaches for Treating Prostate Cancer
title_short Emerging Immunotherapy Approaches for Treating Prostate Cancer
title_sort emerging immunotherapy approaches for treating prostate cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531627/
https://www.ncbi.nlm.nih.gov/pubmed/37762648
http://dx.doi.org/10.3390/ijms241814347
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