The Anion Channel TMEM16a/Ano1 Modulates CFTR Activity, but Does Not Function as an Apical Anion Channel in Colonic Epithelium from Cystic Fibrosis Patients and Healthy Individuals

Studies in human colonic cell lines and murine intestine suggest the presence of a Ca(2+)-activated anion channel, presumably TMEM16a. Is there a potential for fluid secretion in patients with severe cystic fibrosis transmembrane conductance regulator (CFTR) mutations by activating this alternative...

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Detalles Bibliográficos
Autores principales: Salari, Azam, Xiu, Renjie, Amiri, Mahdi, Pallenberg, Sophia Theres, Schreiber, Rainer, Dittrich, Anna-Maria, Tümmler, Burkhard, Kunzelmann, Karl, Seidler, Ursula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531629/
https://www.ncbi.nlm.nih.gov/pubmed/37762516
http://dx.doi.org/10.3390/ijms241814214

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