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Sex-Comparative Outcomes of the T-Branch Device for the Treatment of Complex Aortic Aneurysms
Introduction: Females are at increased risk of mortality compared to males after complex endovascular aortic repair. This study aims to examine sex-related peri-operative and follow-up outcomes in patients managed with the t-Branch device. Methods: A two-center retrospective analysis of patients man...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531663/ https://www.ncbi.nlm.nih.gov/pubmed/37762752 http://dx.doi.org/10.3390/jcm12185811 |
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author | Nana, Petroula Jama, Katarzyna Kölbel, Tilo Spanos, Konstantinos Panuccio, Giuseppe Jakimowicz, Tomasz Rohlffs, Fiona |
author_facet | Nana, Petroula Jama, Katarzyna Kölbel, Tilo Spanos, Konstantinos Panuccio, Giuseppe Jakimowicz, Tomasz Rohlffs, Fiona |
author_sort | Nana, Petroula |
collection | PubMed |
description | Introduction: Females are at increased risk of mortality compared to males after complex endovascular aortic repair. This study aims to examine sex-related peri-operative and follow-up outcomes in patients managed with the t-Branch device. Methods: A two-center retrospective analysis of patients managed with the off-the-shelf t-Branch device (Cook Medical Inc., Bjaeverskov, Denmark) between 1 January 2014 and 30 September 2020 was performed. Primary outcomes were sex-comparative 30-day mortality, major adverse events (MAEs) and spinal cord ischemia (SCI). Results: A total of 542 patients were included; 28.0% were females. Urgent repair and type I–III thoracoabdominal aneurysms were more common among females (52.6% vs. 34%, p = 0.01, and 57.1% vs. 35.8%, p = 0.004). Technical success was similar (97.4% vs. 96.9%, p = 0.755), as well as early mortality (16.2% in females vs. 10.8% in males; p = 0.084). SCI rates were similar between groups (13.6% vs. 9.2% p = 0.183). MAEs were more common in females; 33.7% vs. 21.4% (p = 0.022). Multivariate analysis did not identify sex as an independent predictor of adverse events. The 12-month survival rate was 75.7% (SE 0.045) for females and 84.1% (SE 0.026) for males (log rank, p = 0.10). Conclusions: Sex was not detected as an independent factor of mortality, MAEs and SCI within patients managed with the t-Branch device. Feasibility was high in both groups. No significant difference was shown in survival during the 12-month follow-up. |
format | Online Article Text |
id | pubmed-10531663 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105316632023-09-28 Sex-Comparative Outcomes of the T-Branch Device for the Treatment of Complex Aortic Aneurysms Nana, Petroula Jama, Katarzyna Kölbel, Tilo Spanos, Konstantinos Panuccio, Giuseppe Jakimowicz, Tomasz Rohlffs, Fiona J Clin Med Article Introduction: Females are at increased risk of mortality compared to males after complex endovascular aortic repair. This study aims to examine sex-related peri-operative and follow-up outcomes in patients managed with the t-Branch device. Methods: A two-center retrospective analysis of patients managed with the off-the-shelf t-Branch device (Cook Medical Inc., Bjaeverskov, Denmark) between 1 January 2014 and 30 September 2020 was performed. Primary outcomes were sex-comparative 30-day mortality, major adverse events (MAEs) and spinal cord ischemia (SCI). Results: A total of 542 patients were included; 28.0% were females. Urgent repair and type I–III thoracoabdominal aneurysms were more common among females (52.6% vs. 34%, p = 0.01, and 57.1% vs. 35.8%, p = 0.004). Technical success was similar (97.4% vs. 96.9%, p = 0.755), as well as early mortality (16.2% in females vs. 10.8% in males; p = 0.084). SCI rates were similar between groups (13.6% vs. 9.2% p = 0.183). MAEs were more common in females; 33.7% vs. 21.4% (p = 0.022). Multivariate analysis did not identify sex as an independent predictor of adverse events. The 12-month survival rate was 75.7% (SE 0.045) for females and 84.1% (SE 0.026) for males (log rank, p = 0.10). Conclusions: Sex was not detected as an independent factor of mortality, MAEs and SCI within patients managed with the t-Branch device. Feasibility was high in both groups. No significant difference was shown in survival during the 12-month follow-up. MDPI 2023-09-07 /pmc/articles/PMC10531663/ /pubmed/37762752 http://dx.doi.org/10.3390/jcm12185811 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Nana, Petroula Jama, Katarzyna Kölbel, Tilo Spanos, Konstantinos Panuccio, Giuseppe Jakimowicz, Tomasz Rohlffs, Fiona Sex-Comparative Outcomes of the T-Branch Device for the Treatment of Complex Aortic Aneurysms |
title | Sex-Comparative Outcomes of the T-Branch Device for the Treatment of Complex Aortic Aneurysms |
title_full | Sex-Comparative Outcomes of the T-Branch Device for the Treatment of Complex Aortic Aneurysms |
title_fullStr | Sex-Comparative Outcomes of the T-Branch Device for the Treatment of Complex Aortic Aneurysms |
title_full_unstemmed | Sex-Comparative Outcomes of the T-Branch Device for the Treatment of Complex Aortic Aneurysms |
title_short | Sex-Comparative Outcomes of the T-Branch Device for the Treatment of Complex Aortic Aneurysms |
title_sort | sex-comparative outcomes of the t-branch device for the treatment of complex aortic aneurysms |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531663/ https://www.ncbi.nlm.nih.gov/pubmed/37762752 http://dx.doi.org/10.3390/jcm12185811 |
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