Cargando…

Estimated Pulse Wave Velocity in the Prediction of Clinical Outcomes in Patients Undergoing Drug-Eluting Stent Implantation

Background The prognostic value of estimated pulse wave velocity (ePWV) has been infrequently explored in high-risk patient groups. Our study aimed to evaluate the prognostic significance of ePWV among patients undergoing a percutaneous coronary intervention (PCI) with a drug-eluting stent (DES). Me...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Hack-Lyoung, Joh, Hyun Sung, Lim, Woo-Hyun, Seo, Jae-Bin, Kim, Sang-Hyun, Zo, Joo-Hee, Kim, Myung-A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531714/
https://www.ncbi.nlm.nih.gov/pubmed/37762796
http://dx.doi.org/10.3390/jcm12185855
_version_ 1785111784448851968
author Kim, Hack-Lyoung
Joh, Hyun Sung
Lim, Woo-Hyun
Seo, Jae-Bin
Kim, Sang-Hyun
Zo, Joo-Hee
Kim, Myung-A
author_facet Kim, Hack-Lyoung
Joh, Hyun Sung
Lim, Woo-Hyun
Seo, Jae-Bin
Kim, Sang-Hyun
Zo, Joo-Hee
Kim, Myung-A
author_sort Kim, Hack-Lyoung
collection PubMed
description Background The prognostic value of estimated pulse wave velocity (ePWV) has been infrequently explored in high-risk patient groups. Our study aimed to evaluate the prognostic significance of ePWV among patients undergoing a percutaneous coronary intervention (PCI) with a drug-eluting stent (DES). Methods A total of 4119 consecutive subjects who underwent a PCI with a DES (mean age, 67.1 ± 11.6 years and 33.1% were female) were retrospectively analyzed. ePWV was calculated based on the patient’s age and mean blood pressure. Major adverse cardiovascular events (MACE), including cardiac death, non-fatal myocardial infarction, coronary revascularization, and ischemic stroke, were evaluated. Results During a median follow-up duration of 3.51 years (interquartile range, 1.35–6.37 years), there were 746 MACEs (18.1%). A multivariable analysis showed that a higher ePWV was associated with a higher MACE incidence (middle tertile vs. the lowest tertile: hazard ratio [HR], 2.49; 95% confidence interval [CI], 1.81–3.42; p < 0.001; the highest tertile vs. the lowest tertile: HR, 6.18; 95% CI, 4.33–8.80; p < 0.001) The inclusion of ePWV data significantly increased the global chi-square values when added to the clinical information (from 96 to 128; p < 0.001). Conclusion ePWV demonstrated a significant association with MACEs in patients who underwent DES implantation. Given its relative simplicity to calculate, ePWV could potentially serve as a valuable instrument for stratifying cardiovascular risks within this high-risk patient population.
format Online
Article
Text
id pubmed-10531714
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-105317142023-09-28 Estimated Pulse Wave Velocity in the Prediction of Clinical Outcomes in Patients Undergoing Drug-Eluting Stent Implantation Kim, Hack-Lyoung Joh, Hyun Sung Lim, Woo-Hyun Seo, Jae-Bin Kim, Sang-Hyun Zo, Joo-Hee Kim, Myung-A J Clin Med Article Background The prognostic value of estimated pulse wave velocity (ePWV) has been infrequently explored in high-risk patient groups. Our study aimed to evaluate the prognostic significance of ePWV among patients undergoing a percutaneous coronary intervention (PCI) with a drug-eluting stent (DES). Methods A total of 4119 consecutive subjects who underwent a PCI with a DES (mean age, 67.1 ± 11.6 years and 33.1% were female) were retrospectively analyzed. ePWV was calculated based on the patient’s age and mean blood pressure. Major adverse cardiovascular events (MACE), including cardiac death, non-fatal myocardial infarction, coronary revascularization, and ischemic stroke, were evaluated. Results During a median follow-up duration of 3.51 years (interquartile range, 1.35–6.37 years), there were 746 MACEs (18.1%). A multivariable analysis showed that a higher ePWV was associated with a higher MACE incidence (middle tertile vs. the lowest tertile: hazard ratio [HR], 2.49; 95% confidence interval [CI], 1.81–3.42; p < 0.001; the highest tertile vs. the lowest tertile: HR, 6.18; 95% CI, 4.33–8.80; p < 0.001) The inclusion of ePWV data significantly increased the global chi-square values when added to the clinical information (from 96 to 128; p < 0.001). Conclusion ePWV demonstrated a significant association with MACEs in patients who underwent DES implantation. Given its relative simplicity to calculate, ePWV could potentially serve as a valuable instrument for stratifying cardiovascular risks within this high-risk patient population. MDPI 2023-09-08 /pmc/articles/PMC10531714/ /pubmed/37762796 http://dx.doi.org/10.3390/jcm12185855 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Hack-Lyoung
Joh, Hyun Sung
Lim, Woo-Hyun
Seo, Jae-Bin
Kim, Sang-Hyun
Zo, Joo-Hee
Kim, Myung-A
Estimated Pulse Wave Velocity in the Prediction of Clinical Outcomes in Patients Undergoing Drug-Eluting Stent Implantation
title Estimated Pulse Wave Velocity in the Prediction of Clinical Outcomes in Patients Undergoing Drug-Eluting Stent Implantation
title_full Estimated Pulse Wave Velocity in the Prediction of Clinical Outcomes in Patients Undergoing Drug-Eluting Stent Implantation
title_fullStr Estimated Pulse Wave Velocity in the Prediction of Clinical Outcomes in Patients Undergoing Drug-Eluting Stent Implantation
title_full_unstemmed Estimated Pulse Wave Velocity in the Prediction of Clinical Outcomes in Patients Undergoing Drug-Eluting Stent Implantation
title_short Estimated Pulse Wave Velocity in the Prediction of Clinical Outcomes in Patients Undergoing Drug-Eluting Stent Implantation
title_sort estimated pulse wave velocity in the prediction of clinical outcomes in patients undergoing drug-eluting stent implantation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531714/
https://www.ncbi.nlm.nih.gov/pubmed/37762796
http://dx.doi.org/10.3390/jcm12185855
work_keys_str_mv AT kimhacklyoung estimatedpulsewavevelocityinthepredictionofclinicaloutcomesinpatientsundergoingdrugelutingstentimplantation
AT johhyunsung estimatedpulsewavevelocityinthepredictionofclinicaloutcomesinpatientsundergoingdrugelutingstentimplantation
AT limwoohyun estimatedpulsewavevelocityinthepredictionofclinicaloutcomesinpatientsundergoingdrugelutingstentimplantation
AT seojaebin estimatedpulsewavevelocityinthepredictionofclinicaloutcomesinpatientsundergoingdrugelutingstentimplantation
AT kimsanghyun estimatedpulsewavevelocityinthepredictionofclinicaloutcomesinpatientsundergoingdrugelutingstentimplantation
AT zojoohee estimatedpulsewavevelocityinthepredictionofclinicaloutcomesinpatientsundergoingdrugelutingstentimplantation
AT kimmyunga estimatedpulsewavevelocityinthepredictionofclinicaloutcomesinpatientsundergoingdrugelutingstentimplantation