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Serum Pentraxin 3 as Promising Biomarker for the Long-Lasting Inflammatory Response of COVID-19
Currently, biological markers for COVID-19 disease severity still constitute the main goal of enhancing an efficient treatment to reduce critical consequences such as an abnormal systemic inflammatory response. In this regard, the latest research has shown that Pentraxin 3 (PTX3), a highly conserved...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531731/ https://www.ncbi.nlm.nih.gov/pubmed/37762499 http://dx.doi.org/10.3390/ijms241814195 |
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author | Capra, Anna Paola Crupi, Lelio Pantò, Giuseppe Repici, Alberto Calapai, Fabrizio Squeri, Raffaele Ardizzone, Alessio Esposito, Emanuela |
author_facet | Capra, Anna Paola Crupi, Lelio Pantò, Giuseppe Repici, Alberto Calapai, Fabrizio Squeri, Raffaele Ardizzone, Alessio Esposito, Emanuela |
author_sort | Capra, Anna Paola |
collection | PubMed |
description | Currently, biological markers for COVID-19 disease severity still constitute the main goal of enhancing an efficient treatment to reduce critical consequences such as an abnormal systemic inflammatory response. In this regard, the latest research has shown that Pentraxin 3 (PTX3), a highly conserved innate immunity protein, may serve as a valuable biochemical marker. Based on this evidence, we conducted a case–control study to compare the PTX3 serum levels and several immune-inflammatory mediators of 80 healthcare workers who were subdivided into subjects who were previously infected with SARS-CoV-2 (n = 40) and individuals who were never infected (n = 40). Using a commercially available Enzyme-Linked Immunosorbent Assay (ELISA), PTX3 and various immune-inflammatory protein levels were assessed in serum samples, while also considering possible variables (e.g., gender-related differences). We have shown elevated levels of PTX3 and other inflammatory proteins in previously infected COVID-19-positive subjects (p < 0.001). Moreover, the obtained data also indicate a degree of severity influenced by gender, as shown by the subgroup analysis, in which PTX3 expression was more pronounced in previously COVID-19-positive males (p < 0.001) than in females (p < 0.05) compared to the respective controls. In addition, our data further validate, through a direct comparison of previously COVID-19-positive subjects, greater pro-inflammatory levels in males than in females. Overall, our results may support the validity of PTX3 as a systemic biomarker in prolonged systemic inflammatory responses in the context of COVID-19. Thus, PTX3 modulation could constitute an effective therapeutic strategy for improving the recovery from COVID-19 and its systemic long-term consequences. |
format | Online Article Text |
id | pubmed-10531731 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105317312023-09-28 Serum Pentraxin 3 as Promising Biomarker for the Long-Lasting Inflammatory Response of COVID-19 Capra, Anna Paola Crupi, Lelio Pantò, Giuseppe Repici, Alberto Calapai, Fabrizio Squeri, Raffaele Ardizzone, Alessio Esposito, Emanuela Int J Mol Sci Article Currently, biological markers for COVID-19 disease severity still constitute the main goal of enhancing an efficient treatment to reduce critical consequences such as an abnormal systemic inflammatory response. In this regard, the latest research has shown that Pentraxin 3 (PTX3), a highly conserved innate immunity protein, may serve as a valuable biochemical marker. Based on this evidence, we conducted a case–control study to compare the PTX3 serum levels and several immune-inflammatory mediators of 80 healthcare workers who were subdivided into subjects who were previously infected with SARS-CoV-2 (n = 40) and individuals who were never infected (n = 40). Using a commercially available Enzyme-Linked Immunosorbent Assay (ELISA), PTX3 and various immune-inflammatory protein levels were assessed in serum samples, while also considering possible variables (e.g., gender-related differences). We have shown elevated levels of PTX3 and other inflammatory proteins in previously infected COVID-19-positive subjects (p < 0.001). Moreover, the obtained data also indicate a degree of severity influenced by gender, as shown by the subgroup analysis, in which PTX3 expression was more pronounced in previously COVID-19-positive males (p < 0.001) than in females (p < 0.05) compared to the respective controls. In addition, our data further validate, through a direct comparison of previously COVID-19-positive subjects, greater pro-inflammatory levels in males than in females. Overall, our results may support the validity of PTX3 as a systemic biomarker in prolonged systemic inflammatory responses in the context of COVID-19. Thus, PTX3 modulation could constitute an effective therapeutic strategy for improving the recovery from COVID-19 and its systemic long-term consequences. MDPI 2023-09-17 /pmc/articles/PMC10531731/ /pubmed/37762499 http://dx.doi.org/10.3390/ijms241814195 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Capra, Anna Paola Crupi, Lelio Pantò, Giuseppe Repici, Alberto Calapai, Fabrizio Squeri, Raffaele Ardizzone, Alessio Esposito, Emanuela Serum Pentraxin 3 as Promising Biomarker for the Long-Lasting Inflammatory Response of COVID-19 |
title | Serum Pentraxin 3 as Promising Biomarker for the Long-Lasting Inflammatory Response of COVID-19 |
title_full | Serum Pentraxin 3 as Promising Biomarker for the Long-Lasting Inflammatory Response of COVID-19 |
title_fullStr | Serum Pentraxin 3 as Promising Biomarker for the Long-Lasting Inflammatory Response of COVID-19 |
title_full_unstemmed | Serum Pentraxin 3 as Promising Biomarker for the Long-Lasting Inflammatory Response of COVID-19 |
title_short | Serum Pentraxin 3 as Promising Biomarker for the Long-Lasting Inflammatory Response of COVID-19 |
title_sort | serum pentraxin 3 as promising biomarker for the long-lasting inflammatory response of covid-19 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531731/ https://www.ncbi.nlm.nih.gov/pubmed/37762499 http://dx.doi.org/10.3390/ijms241814195 |
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