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Swiss Pilot Low-Dose CT Lung Cancer Screening Study: First Baseline Screening Results

This pilot study conducted in Switzerland aims to assess the implementation, execution, and performance of low-dose CT lung cancer screening (LDCT-LCS). With lung cancer being the leading cause of cancer-related deaths in Switzerland, the study seeks to explore the potential impact of screening on r...

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Autores principales: Jungblut, Lisa, Etienne, Harry, Zellweger, Caroline, Matter, Alessandra, Patella, Miriam, Frauenfelder, Thomas, Opitz, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531743/
https://www.ncbi.nlm.nih.gov/pubmed/37762713
http://dx.doi.org/10.3390/jcm12185771
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author Jungblut, Lisa
Etienne, Harry
Zellweger, Caroline
Matter, Alessandra
Patella, Miriam
Frauenfelder, Thomas
Opitz, Isabelle
author_facet Jungblut, Lisa
Etienne, Harry
Zellweger, Caroline
Matter, Alessandra
Patella, Miriam
Frauenfelder, Thomas
Opitz, Isabelle
author_sort Jungblut, Lisa
collection PubMed
description This pilot study conducted in Switzerland aims to assess the implementation, execution, and performance of low-dose CT lung cancer screening (LDCT-LCS). With lung cancer being the leading cause of cancer-related deaths in Switzerland, the study seeks to explore the potential impact of screening on reducing mortality rates. However, initiating a lung cancer screening program poses challenges and depends on country-specific factors. This prospective study, initiated in October 2018, enrolled participants meeting the National Lung Cancer Study criteria or a lung cancer risk above 1.5% according to the PLCOm2012 lung cancer risk-model. LDCT scans were assessed using Lung-RADS. Enrollment and follow-up are ongoing. To date, we included 112 participants, with a median age of 62 years (IQR 57–67); 42% were female. The median number of packs smoked each year was 45 (IQR 38–57), and 24% had stopped smoking before enrollment. The mean PLCOm2012 was 3.7% (±2.5%). We diagnosed lung cancer in 3.6% of participants (95%, CI:1.0–12.1%), with various stages, all treated with curative intent. The recall rate for intermediate results (Lung-RADS 3,4a) was 15%. LDCT-LCS in Switzerland, using modified inclusion criteria, is feasible. Further analysis will inform the potential implementation of a comprehensive lung cancer screening program in Switzerland.
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spelling pubmed-105317432023-09-28 Swiss Pilot Low-Dose CT Lung Cancer Screening Study: First Baseline Screening Results Jungblut, Lisa Etienne, Harry Zellweger, Caroline Matter, Alessandra Patella, Miriam Frauenfelder, Thomas Opitz, Isabelle J Clin Med Article This pilot study conducted in Switzerland aims to assess the implementation, execution, and performance of low-dose CT lung cancer screening (LDCT-LCS). With lung cancer being the leading cause of cancer-related deaths in Switzerland, the study seeks to explore the potential impact of screening on reducing mortality rates. However, initiating a lung cancer screening program poses challenges and depends on country-specific factors. This prospective study, initiated in October 2018, enrolled participants meeting the National Lung Cancer Study criteria or a lung cancer risk above 1.5% according to the PLCOm2012 lung cancer risk-model. LDCT scans were assessed using Lung-RADS. Enrollment and follow-up are ongoing. To date, we included 112 participants, with a median age of 62 years (IQR 57–67); 42% were female. The median number of packs smoked each year was 45 (IQR 38–57), and 24% had stopped smoking before enrollment. The mean PLCOm2012 was 3.7% (±2.5%). We diagnosed lung cancer in 3.6% of participants (95%, CI:1.0–12.1%), with various stages, all treated with curative intent. The recall rate for intermediate results (Lung-RADS 3,4a) was 15%. LDCT-LCS in Switzerland, using modified inclusion criteria, is feasible. Further analysis will inform the potential implementation of a comprehensive lung cancer screening program in Switzerland. MDPI 2023-09-05 /pmc/articles/PMC10531743/ /pubmed/37762713 http://dx.doi.org/10.3390/jcm12185771 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jungblut, Lisa
Etienne, Harry
Zellweger, Caroline
Matter, Alessandra
Patella, Miriam
Frauenfelder, Thomas
Opitz, Isabelle
Swiss Pilot Low-Dose CT Lung Cancer Screening Study: First Baseline Screening Results
title Swiss Pilot Low-Dose CT Lung Cancer Screening Study: First Baseline Screening Results
title_full Swiss Pilot Low-Dose CT Lung Cancer Screening Study: First Baseline Screening Results
title_fullStr Swiss Pilot Low-Dose CT Lung Cancer Screening Study: First Baseline Screening Results
title_full_unstemmed Swiss Pilot Low-Dose CT Lung Cancer Screening Study: First Baseline Screening Results
title_short Swiss Pilot Low-Dose CT Lung Cancer Screening Study: First Baseline Screening Results
title_sort swiss pilot low-dose ct lung cancer screening study: first baseline screening results
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531743/
https://www.ncbi.nlm.nih.gov/pubmed/37762713
http://dx.doi.org/10.3390/jcm12185771
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