Cargando…
Swiss Pilot Low-Dose CT Lung Cancer Screening Study: First Baseline Screening Results
This pilot study conducted in Switzerland aims to assess the implementation, execution, and performance of low-dose CT lung cancer screening (LDCT-LCS). With lung cancer being the leading cause of cancer-related deaths in Switzerland, the study seeks to explore the potential impact of screening on r...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531743/ https://www.ncbi.nlm.nih.gov/pubmed/37762713 http://dx.doi.org/10.3390/jcm12185771 |
_version_ | 1785111791523594240 |
---|---|
author | Jungblut, Lisa Etienne, Harry Zellweger, Caroline Matter, Alessandra Patella, Miriam Frauenfelder, Thomas Opitz, Isabelle |
author_facet | Jungblut, Lisa Etienne, Harry Zellweger, Caroline Matter, Alessandra Patella, Miriam Frauenfelder, Thomas Opitz, Isabelle |
author_sort | Jungblut, Lisa |
collection | PubMed |
description | This pilot study conducted in Switzerland aims to assess the implementation, execution, and performance of low-dose CT lung cancer screening (LDCT-LCS). With lung cancer being the leading cause of cancer-related deaths in Switzerland, the study seeks to explore the potential impact of screening on reducing mortality rates. However, initiating a lung cancer screening program poses challenges and depends on country-specific factors. This prospective study, initiated in October 2018, enrolled participants meeting the National Lung Cancer Study criteria or a lung cancer risk above 1.5% according to the PLCOm2012 lung cancer risk-model. LDCT scans were assessed using Lung-RADS. Enrollment and follow-up are ongoing. To date, we included 112 participants, with a median age of 62 years (IQR 57–67); 42% were female. The median number of packs smoked each year was 45 (IQR 38–57), and 24% had stopped smoking before enrollment. The mean PLCOm2012 was 3.7% (±2.5%). We diagnosed lung cancer in 3.6% of participants (95%, CI:1.0–12.1%), with various stages, all treated with curative intent. The recall rate for intermediate results (Lung-RADS 3,4a) was 15%. LDCT-LCS in Switzerland, using modified inclusion criteria, is feasible. Further analysis will inform the potential implementation of a comprehensive lung cancer screening program in Switzerland. |
format | Online Article Text |
id | pubmed-10531743 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105317432023-09-28 Swiss Pilot Low-Dose CT Lung Cancer Screening Study: First Baseline Screening Results Jungblut, Lisa Etienne, Harry Zellweger, Caroline Matter, Alessandra Patella, Miriam Frauenfelder, Thomas Opitz, Isabelle J Clin Med Article This pilot study conducted in Switzerland aims to assess the implementation, execution, and performance of low-dose CT lung cancer screening (LDCT-LCS). With lung cancer being the leading cause of cancer-related deaths in Switzerland, the study seeks to explore the potential impact of screening on reducing mortality rates. However, initiating a lung cancer screening program poses challenges and depends on country-specific factors. This prospective study, initiated in October 2018, enrolled participants meeting the National Lung Cancer Study criteria or a lung cancer risk above 1.5% according to the PLCOm2012 lung cancer risk-model. LDCT scans were assessed using Lung-RADS. Enrollment and follow-up are ongoing. To date, we included 112 participants, with a median age of 62 years (IQR 57–67); 42% were female. The median number of packs smoked each year was 45 (IQR 38–57), and 24% had stopped smoking before enrollment. The mean PLCOm2012 was 3.7% (±2.5%). We diagnosed lung cancer in 3.6% of participants (95%, CI:1.0–12.1%), with various stages, all treated with curative intent. The recall rate for intermediate results (Lung-RADS 3,4a) was 15%. LDCT-LCS in Switzerland, using modified inclusion criteria, is feasible. Further analysis will inform the potential implementation of a comprehensive lung cancer screening program in Switzerland. MDPI 2023-09-05 /pmc/articles/PMC10531743/ /pubmed/37762713 http://dx.doi.org/10.3390/jcm12185771 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Jungblut, Lisa Etienne, Harry Zellweger, Caroline Matter, Alessandra Patella, Miriam Frauenfelder, Thomas Opitz, Isabelle Swiss Pilot Low-Dose CT Lung Cancer Screening Study: First Baseline Screening Results |
title | Swiss Pilot Low-Dose CT Lung Cancer Screening Study: First Baseline Screening Results |
title_full | Swiss Pilot Low-Dose CT Lung Cancer Screening Study: First Baseline Screening Results |
title_fullStr | Swiss Pilot Low-Dose CT Lung Cancer Screening Study: First Baseline Screening Results |
title_full_unstemmed | Swiss Pilot Low-Dose CT Lung Cancer Screening Study: First Baseline Screening Results |
title_short | Swiss Pilot Low-Dose CT Lung Cancer Screening Study: First Baseline Screening Results |
title_sort | swiss pilot low-dose ct lung cancer screening study: first baseline screening results |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531743/ https://www.ncbi.nlm.nih.gov/pubmed/37762713 http://dx.doi.org/10.3390/jcm12185771 |
work_keys_str_mv | AT jungblutlisa swisspilotlowdosectlungcancerscreeningstudyfirstbaselinescreeningresults AT etienneharry swisspilotlowdosectlungcancerscreeningstudyfirstbaselinescreeningresults AT zellwegercaroline swisspilotlowdosectlungcancerscreeningstudyfirstbaselinescreeningresults AT matteralessandra swisspilotlowdosectlungcancerscreeningstudyfirstbaselinescreeningresults AT patellamiriam swisspilotlowdosectlungcancerscreeningstudyfirstbaselinescreeningresults AT frauenfelderthomas swisspilotlowdosectlungcancerscreeningstudyfirstbaselinescreeningresults AT opitzisabelle swisspilotlowdosectlungcancerscreeningstudyfirstbaselinescreeningresults |