Cargando…

Heterologous Interactions with Galectins and Chemokines and Their Functional Consequences

Extra- and intra-cellular activity occurs under the direction of numerous inter-molecular interactions, and in any tissue or cell, molecules are densely packed, thus promoting those molecular interactions. Galectins and chemokines, the focus of this review, are small, protein effector molecules that...

Descripción completa

Detalles Bibliográficos
Autor principal: Mayo, Kevin H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531749/
https://www.ncbi.nlm.nih.gov/pubmed/37762385
http://dx.doi.org/10.3390/ijms241814083
_version_ 1785111792971677696
author Mayo, Kevin H.
author_facet Mayo, Kevin H.
author_sort Mayo, Kevin H.
collection PubMed
description Extra- and intra-cellular activity occurs under the direction of numerous inter-molecular interactions, and in any tissue or cell, molecules are densely packed, thus promoting those molecular interactions. Galectins and chemokines, the focus of this review, are small, protein effector molecules that mediate various cellular functions—in particular, cell adhesion and migration—as well as cell signaling/activation. In the past, researchers have reported that combinations of these (and other) effector molecules act separately, yet sometimes in concert, but nevertheless physically apart and via their individual cell receptors. This view that each effector molecule functions independently of the other limits our thinking about functional versatility and cooperation, and, in turn, ignores the prospect of physiologically important inter-molecular interactions, especially when both molecules are present or co-expressed in the same cellular environment. This review is focused on such protein-protein interactions with chemokines and galectins, the homo- and hetero-oligomeric structures that they can form, and the functional consequences of those paired interactions.
format Online
Article
Text
id pubmed-10531749
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-105317492023-09-28 Heterologous Interactions with Galectins and Chemokines and Their Functional Consequences Mayo, Kevin H. Int J Mol Sci Review Extra- and intra-cellular activity occurs under the direction of numerous inter-molecular interactions, and in any tissue or cell, molecules are densely packed, thus promoting those molecular interactions. Galectins and chemokines, the focus of this review, are small, protein effector molecules that mediate various cellular functions—in particular, cell adhesion and migration—as well as cell signaling/activation. In the past, researchers have reported that combinations of these (and other) effector molecules act separately, yet sometimes in concert, but nevertheless physically apart and via their individual cell receptors. This view that each effector molecule functions independently of the other limits our thinking about functional versatility and cooperation, and, in turn, ignores the prospect of physiologically important inter-molecular interactions, especially when both molecules are present or co-expressed in the same cellular environment. This review is focused on such protein-protein interactions with chemokines and galectins, the homo- and hetero-oligomeric structures that they can form, and the functional consequences of those paired interactions. MDPI 2023-09-14 /pmc/articles/PMC10531749/ /pubmed/37762385 http://dx.doi.org/10.3390/ijms241814083 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mayo, Kevin H.
Heterologous Interactions with Galectins and Chemokines and Their Functional Consequences
title Heterologous Interactions with Galectins and Chemokines and Their Functional Consequences
title_full Heterologous Interactions with Galectins and Chemokines and Their Functional Consequences
title_fullStr Heterologous Interactions with Galectins and Chemokines and Their Functional Consequences
title_full_unstemmed Heterologous Interactions with Galectins and Chemokines and Their Functional Consequences
title_short Heterologous Interactions with Galectins and Chemokines and Their Functional Consequences
title_sort heterologous interactions with galectins and chemokines and their functional consequences
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531749/
https://www.ncbi.nlm.nih.gov/pubmed/37762385
http://dx.doi.org/10.3390/ijms241814083
work_keys_str_mv AT mayokevinh heterologousinteractionswithgalectinsandchemokinesandtheirfunctionalconsequences