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Heterologous Interactions with Galectins and Chemokines and Their Functional Consequences
Extra- and intra-cellular activity occurs under the direction of numerous inter-molecular interactions, and in any tissue or cell, molecules are densely packed, thus promoting those molecular interactions. Galectins and chemokines, the focus of this review, are small, protein effector molecules that...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531749/ https://www.ncbi.nlm.nih.gov/pubmed/37762385 http://dx.doi.org/10.3390/ijms241814083 |
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author | Mayo, Kevin H. |
author_facet | Mayo, Kevin H. |
author_sort | Mayo, Kevin H. |
collection | PubMed |
description | Extra- and intra-cellular activity occurs under the direction of numerous inter-molecular interactions, and in any tissue or cell, molecules are densely packed, thus promoting those molecular interactions. Galectins and chemokines, the focus of this review, are small, protein effector molecules that mediate various cellular functions—in particular, cell adhesion and migration—as well as cell signaling/activation. In the past, researchers have reported that combinations of these (and other) effector molecules act separately, yet sometimes in concert, but nevertheless physically apart and via their individual cell receptors. This view that each effector molecule functions independently of the other limits our thinking about functional versatility and cooperation, and, in turn, ignores the prospect of physiologically important inter-molecular interactions, especially when both molecules are present or co-expressed in the same cellular environment. This review is focused on such protein-protein interactions with chemokines and galectins, the homo- and hetero-oligomeric structures that they can form, and the functional consequences of those paired interactions. |
format | Online Article Text |
id | pubmed-10531749 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105317492023-09-28 Heterologous Interactions with Galectins and Chemokines and Their Functional Consequences Mayo, Kevin H. Int J Mol Sci Review Extra- and intra-cellular activity occurs under the direction of numerous inter-molecular interactions, and in any tissue or cell, molecules are densely packed, thus promoting those molecular interactions. Galectins and chemokines, the focus of this review, are small, protein effector molecules that mediate various cellular functions—in particular, cell adhesion and migration—as well as cell signaling/activation. In the past, researchers have reported that combinations of these (and other) effector molecules act separately, yet sometimes in concert, but nevertheless physically apart and via their individual cell receptors. This view that each effector molecule functions independently of the other limits our thinking about functional versatility and cooperation, and, in turn, ignores the prospect of physiologically important inter-molecular interactions, especially when both molecules are present or co-expressed in the same cellular environment. This review is focused on such protein-protein interactions with chemokines and galectins, the homo- and hetero-oligomeric structures that they can form, and the functional consequences of those paired interactions. MDPI 2023-09-14 /pmc/articles/PMC10531749/ /pubmed/37762385 http://dx.doi.org/10.3390/ijms241814083 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mayo, Kevin H. Heterologous Interactions with Galectins and Chemokines and Their Functional Consequences |
title | Heterologous Interactions with Galectins and Chemokines and Their Functional Consequences |
title_full | Heterologous Interactions with Galectins and Chemokines and Their Functional Consequences |
title_fullStr | Heterologous Interactions with Galectins and Chemokines and Their Functional Consequences |
title_full_unstemmed | Heterologous Interactions with Galectins and Chemokines and Their Functional Consequences |
title_short | Heterologous Interactions with Galectins and Chemokines and Their Functional Consequences |
title_sort | heterologous interactions with galectins and chemokines and their functional consequences |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531749/ https://www.ncbi.nlm.nih.gov/pubmed/37762385 http://dx.doi.org/10.3390/ijms241814083 |
work_keys_str_mv | AT mayokevinh heterologousinteractionswithgalectinsandchemokinesandtheirfunctionalconsequences |