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Current Trend and New Opportunities for Multifunctional Bio-Scaffold Fabrication via High-Pressure Foaming

Biocompatible and biodegradable foams prepared using the high-pressure foaming technique have been widely investigated in recent decades as porous scaffolds for in vitro and in vivo tissue growth. In fact, the foaming process can operate at low temperatures to load bioactive molecules and cells with...

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Autores principales: Fanovich, María Alejandra, Di Maio, Ernesto, Salerno, Aurelio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531842/
https://www.ncbi.nlm.nih.gov/pubmed/37754894
http://dx.doi.org/10.3390/jfb14090480
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author Fanovich, María Alejandra
Di Maio, Ernesto
Salerno, Aurelio
author_facet Fanovich, María Alejandra
Di Maio, Ernesto
Salerno, Aurelio
author_sort Fanovich, María Alejandra
collection PubMed
description Biocompatible and biodegradable foams prepared using the high-pressure foaming technique have been widely investigated in recent decades as porous scaffolds for in vitro and in vivo tissue growth. In fact, the foaming process can operate at low temperatures to load bioactive molecules and cells within the pores of the scaffold, while the density and pore architecture, and, hence, properties of the scaffold, can be finely modulated by the proper selection of materials and processing conditions. Most importantly, the high-pressure foaming of polymers is an ideal choice to limit and/or avoid the use of cytotoxic and tissue-toxic compounds during scaffold preparation. The aim of this review is to provide the reader with the state of the art and current trend in the high-pressure foaming of biomedical polymers and composites towards the design and fabrication of multifunctional scaffolds for tissue engineering. This manuscript describes the application of the gas foaming process for bio-scaffold design and fabrication and highlights some of the most interesting results on: (1) the engineering of porous scaffolds featuring biomimetic porosity to guide cell behavior and to mimic the hierarchical architecture of complex tissues, such as bone; (2) the bioactivation of the scaffolds through the incorporation of inorganic fillers and drugs.
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spelling pubmed-105318422023-09-28 Current Trend and New Opportunities for Multifunctional Bio-Scaffold Fabrication via High-Pressure Foaming Fanovich, María Alejandra Di Maio, Ernesto Salerno, Aurelio J Funct Biomater Review Biocompatible and biodegradable foams prepared using the high-pressure foaming technique have been widely investigated in recent decades as porous scaffolds for in vitro and in vivo tissue growth. In fact, the foaming process can operate at low temperatures to load bioactive molecules and cells within the pores of the scaffold, while the density and pore architecture, and, hence, properties of the scaffold, can be finely modulated by the proper selection of materials and processing conditions. Most importantly, the high-pressure foaming of polymers is an ideal choice to limit and/or avoid the use of cytotoxic and tissue-toxic compounds during scaffold preparation. The aim of this review is to provide the reader with the state of the art and current trend in the high-pressure foaming of biomedical polymers and composites towards the design and fabrication of multifunctional scaffolds for tissue engineering. This manuscript describes the application of the gas foaming process for bio-scaffold design and fabrication and highlights some of the most interesting results on: (1) the engineering of porous scaffolds featuring biomimetic porosity to guide cell behavior and to mimic the hierarchical architecture of complex tissues, such as bone; (2) the bioactivation of the scaffolds through the incorporation of inorganic fillers and drugs. MDPI 2023-09-19 /pmc/articles/PMC10531842/ /pubmed/37754894 http://dx.doi.org/10.3390/jfb14090480 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fanovich, María Alejandra
Di Maio, Ernesto
Salerno, Aurelio
Current Trend and New Opportunities for Multifunctional Bio-Scaffold Fabrication via High-Pressure Foaming
title Current Trend and New Opportunities for Multifunctional Bio-Scaffold Fabrication via High-Pressure Foaming
title_full Current Trend and New Opportunities for Multifunctional Bio-Scaffold Fabrication via High-Pressure Foaming
title_fullStr Current Trend and New Opportunities for Multifunctional Bio-Scaffold Fabrication via High-Pressure Foaming
title_full_unstemmed Current Trend and New Opportunities for Multifunctional Bio-Scaffold Fabrication via High-Pressure Foaming
title_short Current Trend and New Opportunities for Multifunctional Bio-Scaffold Fabrication via High-Pressure Foaming
title_sort current trend and new opportunities for multifunctional bio-scaffold fabrication via high-pressure foaming
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531842/
https://www.ncbi.nlm.nih.gov/pubmed/37754894
http://dx.doi.org/10.3390/jfb14090480
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