Osteoporosis as the First Sign of Cushing’s Disease in a Thin 16-Year-Old Boy—A Case Report

Cushing’s disease (CD) is an extremely rare diagnosis in children. In this report, we present the case of an almost 16-year-old, short and thin boy with CD, the first symptoms of which were spinal pain and vertebral fractures as a result of osteoporosis. In light of his growth retardation and short...

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Autores principales: Łupińska, Anna, Aszkiełowicz, Sara, Zieliński, Grzegorz, Stawerska, Renata, Lewiński, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531847/
https://www.ncbi.nlm.nih.gov/pubmed/37762908
http://dx.doi.org/10.3390/jcm12185967
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author Łupińska, Anna
Aszkiełowicz, Sara
Zieliński, Grzegorz
Stawerska, Renata
Lewiński, Andrzej
author_facet Łupińska, Anna
Aszkiełowicz, Sara
Zieliński, Grzegorz
Stawerska, Renata
Lewiński, Andrzej
author_sort Łupińska, Anna
collection PubMed
description Cushing’s disease (CD) is an extremely rare diagnosis in children. In this report, we present the case of an almost 16-year-old, short and thin boy with CD, the first symptoms of which were spinal pain and vertebral fractures as a result of osteoporosis. In light of his growth retardation and short stature, the boy underwent diagnostics, which excluded growth hormone (GH) deficiency, hypothyroidism and celiac disease. Finally, based on cortisol profile results, dexamethasone suppression tests and bilateral sampling during catheterization of the inferior petrosal sinuses, CD was diagnosed.
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spelling pubmed-105318472023-09-28 Osteoporosis as the First Sign of Cushing’s Disease in a Thin 16-Year-Old Boy—A Case Report Łupińska, Anna Aszkiełowicz, Sara Zieliński, Grzegorz Stawerska, Renata Lewiński, Andrzej J Clin Med Case Report Cushing’s disease (CD) is an extremely rare diagnosis in children. In this report, we present the case of an almost 16-year-old, short and thin boy with CD, the first symptoms of which were spinal pain and vertebral fractures as a result of osteoporosis. In light of his growth retardation and short stature, the boy underwent diagnostics, which excluded growth hormone (GH) deficiency, hypothyroidism and celiac disease. Finally, based on cortisol profile results, dexamethasone suppression tests and bilateral sampling during catheterization of the inferior petrosal sinuses, CD was diagnosed. MDPI 2023-09-14 /pmc/articles/PMC10531847/ /pubmed/37762908 http://dx.doi.org/10.3390/jcm12185967 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Łupińska, Anna
Aszkiełowicz, Sara
Zieliński, Grzegorz
Stawerska, Renata
Lewiński, Andrzej
Osteoporosis as the First Sign of Cushing’s Disease in a Thin 16-Year-Old Boy—A Case Report
title Osteoporosis as the First Sign of Cushing’s Disease in a Thin 16-Year-Old Boy—A Case Report
title_full Osteoporosis as the First Sign of Cushing’s Disease in a Thin 16-Year-Old Boy—A Case Report
title_fullStr Osteoporosis as the First Sign of Cushing’s Disease in a Thin 16-Year-Old Boy—A Case Report
title_full_unstemmed Osteoporosis as the First Sign of Cushing’s Disease in a Thin 16-Year-Old Boy—A Case Report
title_short Osteoporosis as the First Sign of Cushing’s Disease in a Thin 16-Year-Old Boy—A Case Report
title_sort osteoporosis as the first sign of cushing’s disease in a thin 16-year-old boy—a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531847/
https://www.ncbi.nlm.nih.gov/pubmed/37762908
http://dx.doi.org/10.3390/jcm12185967
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