Role of the Lactide:Glycolide Ratio in PLGA Nanoparticle Stability and Release under Lysosomal Conditions for Enzyme Replacement Therapy of Lysosomal Storage Disorders

Prior studies demonstrated that encapsulation in poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) enhanced the delivery of enzymes used for replacement therapy (ERT) of lysosomal storage disorders (LSDs). This study examined how the copolymer lactide:glycolide ratio impacts encapsulation, ph...

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Detalles Bibliográficos
Autores principales: del Moral, Maria, Loeck, Maximilian, Muntimadugu, Eameema, Vives, Guillem, Pham, Vy, Pfeifer, Peter, Battaglia, Giuseppe, Muro, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531859/
https://www.ncbi.nlm.nih.gov/pubmed/37754854
http://dx.doi.org/10.3390/jfb14090440

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