Nebulized Recombinant Tissue Plasminogen Activator (rt-PA) for Acute COVID-19-Induced Respiratory Failure: An Exploratory Proof-of-Concept Trial

Acute lung injury in COVID-19 results in diffuse alveolar damage with disruption of the alveolar-capillary barrier, coagulation activation, alveolar fibrin deposition and pulmonary capillary thrombi. Nebulized recombinant tissue plasminogen activator (rt-PA) has the potential to facilitate localized...

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Detalles Bibliográficos
Autores principales: Chowdary, Pratima, Agarwal, Banwari, Peralta, Maria Rita, Bhagani, Sanjay, Lee, Simon, Goldring, James, Lipman, Marc, Waqif, Emal, Phillips, Mark, Philippou, Helen, Foley, Jonathan H., Mutch, Nicola J., Ariëns, Robert A. S., Stringer, Kathleen A., Ricciardi, Federico, Watissée, Marie, Hughes, Derralynn, Nathwani, Amit, Riddell, Anne, Patch, David, Buckley, Jim, De Neef, Mark, Dimber, Rahul, Diaz-Garcia, Cecilia, Patel, Honey, Nandani, Aarti, Dissanayake, Upuli, Chadwick, Nick, Alkhatip, Ahmed A. A. M. M., Watkinson, Peter, Raith, Eamon, Singh, Suveer, Wolff, Tony, Jha, Rajeev, Brill, Simon E., Bakhai, Ameet, Evans, Alison, Gilani, Farhat, Gomez, Keith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531875/
https://www.ncbi.nlm.nih.gov/pubmed/37762789
http://dx.doi.org/10.3390/jcm12185848

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