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The Porous Structure of Peripheral Nerve Guidance Conduits: Features, Fabrication, and Implications for Peripheral Nerve Regeneration

Porous structure is an important three-dimensional morphological feature of the peripheral nerve guidance conduit (NGC), which permits the infiltration of cells, nutrients, and molecular signals and the discharge of metabolic waste. Porous structures with precisely customized pore sizes, porosities,...

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Autores principales: Wan, Teng, Wang, Yi-Lin, Zhang, Feng-Shi, Zhang, Xiao-Meng, Zhang, Yi-Chong, Jiang, Hao-Ran, Zhang, Meng, Zhang, Pei-Xun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531895/
https://www.ncbi.nlm.nih.gov/pubmed/37762437
http://dx.doi.org/10.3390/ijms241814132
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author Wan, Teng
Wang, Yi-Lin
Zhang, Feng-Shi
Zhang, Xiao-Meng
Zhang, Yi-Chong
Jiang, Hao-Ran
Zhang, Meng
Zhang, Pei-Xun
author_facet Wan, Teng
Wang, Yi-Lin
Zhang, Feng-Shi
Zhang, Xiao-Meng
Zhang, Yi-Chong
Jiang, Hao-Ran
Zhang, Meng
Zhang, Pei-Xun
author_sort Wan, Teng
collection PubMed
description Porous structure is an important three-dimensional morphological feature of the peripheral nerve guidance conduit (NGC), which permits the infiltration of cells, nutrients, and molecular signals and the discharge of metabolic waste. Porous structures with precisely customized pore sizes, porosities, and connectivities are being used to construct fully permeable, semi-permeable, and asymmetric peripheral NGCs for the replacement of traditional nerve autografts in the treatment of long-segment peripheral nerve injury. In this review, the features of porous structures and the classification of NGCs based on these characteristics are discussed. Common methods for constructing 3D porous NGCs in current research are described, as well as the pore characteristics and the parameters used to tune the pores. The effects of the porous structure on the physical properties of NGCs, including biodegradation, mechanical performance, and permeability, were analyzed. Pore structure affects the biological behavior of Schwann cells, macrophages, fibroblasts, and vascular endothelial cells during peripheral nerve regeneration. The construction of ideal porous structures is a significant advancement in the regeneration of peripheral nerve tissue engineering materials. The purpose of this review is to generalize, summarize, and analyze methods for the preparation of porous NGCs and their biological functions in promoting peripheral nerve regeneration to guide the development of medical nerve repair materials.
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spelling pubmed-105318952023-09-28 The Porous Structure of Peripheral Nerve Guidance Conduits: Features, Fabrication, and Implications for Peripheral Nerve Regeneration Wan, Teng Wang, Yi-Lin Zhang, Feng-Shi Zhang, Xiao-Meng Zhang, Yi-Chong Jiang, Hao-Ran Zhang, Meng Zhang, Pei-Xun Int J Mol Sci Review Porous structure is an important three-dimensional morphological feature of the peripheral nerve guidance conduit (NGC), which permits the infiltration of cells, nutrients, and molecular signals and the discharge of metabolic waste. Porous structures with precisely customized pore sizes, porosities, and connectivities are being used to construct fully permeable, semi-permeable, and asymmetric peripheral NGCs for the replacement of traditional nerve autografts in the treatment of long-segment peripheral nerve injury. In this review, the features of porous structures and the classification of NGCs based on these characteristics are discussed. Common methods for constructing 3D porous NGCs in current research are described, as well as the pore characteristics and the parameters used to tune the pores. The effects of the porous structure on the physical properties of NGCs, including biodegradation, mechanical performance, and permeability, were analyzed. Pore structure affects the biological behavior of Schwann cells, macrophages, fibroblasts, and vascular endothelial cells during peripheral nerve regeneration. The construction of ideal porous structures is a significant advancement in the regeneration of peripheral nerve tissue engineering materials. The purpose of this review is to generalize, summarize, and analyze methods for the preparation of porous NGCs and their biological functions in promoting peripheral nerve regeneration to guide the development of medical nerve repair materials. MDPI 2023-09-15 /pmc/articles/PMC10531895/ /pubmed/37762437 http://dx.doi.org/10.3390/ijms241814132 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wan, Teng
Wang, Yi-Lin
Zhang, Feng-Shi
Zhang, Xiao-Meng
Zhang, Yi-Chong
Jiang, Hao-Ran
Zhang, Meng
Zhang, Pei-Xun
The Porous Structure of Peripheral Nerve Guidance Conduits: Features, Fabrication, and Implications for Peripheral Nerve Regeneration
title The Porous Structure of Peripheral Nerve Guidance Conduits: Features, Fabrication, and Implications for Peripheral Nerve Regeneration
title_full The Porous Structure of Peripheral Nerve Guidance Conduits: Features, Fabrication, and Implications for Peripheral Nerve Regeneration
title_fullStr The Porous Structure of Peripheral Nerve Guidance Conduits: Features, Fabrication, and Implications for Peripheral Nerve Regeneration
title_full_unstemmed The Porous Structure of Peripheral Nerve Guidance Conduits: Features, Fabrication, and Implications for Peripheral Nerve Regeneration
title_short The Porous Structure of Peripheral Nerve Guidance Conduits: Features, Fabrication, and Implications for Peripheral Nerve Regeneration
title_sort porous structure of peripheral nerve guidance conduits: features, fabrication, and implications for peripheral nerve regeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531895/
https://www.ncbi.nlm.nih.gov/pubmed/37762437
http://dx.doi.org/10.3390/ijms241814132
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