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Emerging Roles of Using Small Extracellular Vesicles as an Anti-Cancer Drug

Small extracellular vesicles (sEVs) are emerging as a novel therapeutic strategy for cancer therapy. Tumor-cell-derived sEVs contain biomolecules that can be utilized for cancer diagnosis. sEVs can directly exert tumor-killing effects or modulate the tumor microenvironment, leading to anti-cancer ef...

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Autores principales: Joo, Hyeon Su, Suh, Ju Hun, So, Chan Mi, Jeon, Hye Jin, Yoon, Sol Hee, Lee, Jung Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531913/
https://www.ncbi.nlm.nih.gov/pubmed/37762393
http://dx.doi.org/10.3390/ijms241814063
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author Joo, Hyeon Su
Suh, Ju Hun
So, Chan Mi
Jeon, Hye Jin
Yoon, Sol Hee
Lee, Jung Min
author_facet Joo, Hyeon Su
Suh, Ju Hun
So, Chan Mi
Jeon, Hye Jin
Yoon, Sol Hee
Lee, Jung Min
author_sort Joo, Hyeon Su
collection PubMed
description Small extracellular vesicles (sEVs) are emerging as a novel therapeutic strategy for cancer therapy. Tumor-cell-derived sEVs contain biomolecules that can be utilized for cancer diagnosis. sEVs can directly exert tumor-killing effects or modulate the tumor microenvironment, leading to anti-cancer effects. In this review, the application of sEVs as a diagnostic tool, drug delivery system, and active pharmaceutical ingredient for cancer therapy will be highlighted. The therapeutic efficacies of sEVs will be compared to conventional immune checkpoint inhibitors. Additionally, this review will provide strategies for sEV engineering to enhance the therapeutic efficacies of sEVs. As a bench-to-bedside application, we will discuss approaches to encourage good-manufacturing-practice-compliant industrial-scale manufacturing and purification of sEVs.
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spelling pubmed-105319132023-09-28 Emerging Roles of Using Small Extracellular Vesicles as an Anti-Cancer Drug Joo, Hyeon Su Suh, Ju Hun So, Chan Mi Jeon, Hye Jin Yoon, Sol Hee Lee, Jung Min Int J Mol Sci Review Small extracellular vesicles (sEVs) are emerging as a novel therapeutic strategy for cancer therapy. Tumor-cell-derived sEVs contain biomolecules that can be utilized for cancer diagnosis. sEVs can directly exert tumor-killing effects or modulate the tumor microenvironment, leading to anti-cancer effects. In this review, the application of sEVs as a diagnostic tool, drug delivery system, and active pharmaceutical ingredient for cancer therapy will be highlighted. The therapeutic efficacies of sEVs will be compared to conventional immune checkpoint inhibitors. Additionally, this review will provide strategies for sEV engineering to enhance the therapeutic efficacies of sEVs. As a bench-to-bedside application, we will discuss approaches to encourage good-manufacturing-practice-compliant industrial-scale manufacturing and purification of sEVs. MDPI 2023-09-14 /pmc/articles/PMC10531913/ /pubmed/37762393 http://dx.doi.org/10.3390/ijms241814063 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Joo, Hyeon Su
Suh, Ju Hun
So, Chan Mi
Jeon, Hye Jin
Yoon, Sol Hee
Lee, Jung Min
Emerging Roles of Using Small Extracellular Vesicles as an Anti-Cancer Drug
title Emerging Roles of Using Small Extracellular Vesicles as an Anti-Cancer Drug
title_full Emerging Roles of Using Small Extracellular Vesicles as an Anti-Cancer Drug
title_fullStr Emerging Roles of Using Small Extracellular Vesicles as an Anti-Cancer Drug
title_full_unstemmed Emerging Roles of Using Small Extracellular Vesicles as an Anti-Cancer Drug
title_short Emerging Roles of Using Small Extracellular Vesicles as an Anti-Cancer Drug
title_sort emerging roles of using small extracellular vesicles as an anti-cancer drug
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531913/
https://www.ncbi.nlm.nih.gov/pubmed/37762393
http://dx.doi.org/10.3390/ijms241814063
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