Cargando…

Uridine as a Regulator of Functional and Ultrastructural Changes in the Brain of Rats in a Model of 6-OHDA-Induced Parkinson’s Disease

Using a model of Parkinson’s disease (PD) induced by the bilateral injection of neurotoxin 6-hydroxydopamine (6-OHDA) into rat brain substantia nigra (SN), we showed uridine to exert a protective effect associated with activation of the mitochondrial ATP-dependent potassium (mitoK-ATP) channel. Inje...

Descripción completa

Detalles Bibliográficos
Autores principales:	Uspalenko, Nina I., Mosentsov, Alexei A., Khmil, Natalia V., Pavlik, Lyubov L., Belosludtseva, Natalia V., Khunderyakova, Natalia V., Shigaeva, Maria I., Medvedeva, Vasilisa P., Malkov, Anton E., Kitchigina, Valentina F., Mironova, Galina D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531918/ https://www.ncbi.nlm.nih.gov/pubmed/37762607 http://dx.doi.org/10.3390/ijms241814304

Ejemplares similares

Uridine as a protector against hypoxia-induced lung injury
por: Rozova, Ekaterina V., et al.
Publicado: (2019)

Uridine treatment prevents myocardial injury in rat models of acute ischemia and ischemia/reperfusion by activating the mitochondrial ATP-dependent potassium channel
por: Krylova, Irina B., et al.
Publicado: (2021)

Signaling Role of Mitochondrial Enzymes and Ultrastructure in the Formation of Molecular Mechanisms of Adaptation to Hypoxia
por: Lukyanova, Ludmila, et al.
Publicado: (2021)

The Short-Term Opening of Cyclosporin A-Independent Palmitate/Sr(2+)-Induced Pore Can Underlie Ion Efflux in the Oscillatory Mode of Functioning of Rat Liver Mitochondria
por: Belosludtseva, Natalia V., et al.
Publicado: (2022)

A Comparative Analysis of Neuroprotective Properties of Taxifolin and Its Water-Soluble Form in Ischemia of Cerebral Cortical Cells of the Mouse
por: Varlamova, Elena G., et al.
Publicado: (2023)

The Role of Mitochondrial Enzymes, Succinate-Coupled Signaling Pathways and Mitochondrial Ultrastructure in the Formation of Urgent Adaptation to Acute Hypoxia in the Myocardium
por: Germanova, Elita, et al.
Publicado: (2022)

Effect of Chronic Treatment with Uridine on Cardiac Mitochondrial Dysfunction in the C57BL/6 Mouse Model of High-Fat Diet–Streptozotocin-Induced Diabetes
por: Belosludtseva, Natalia V., et al.
Publicado: (2022)

The Effect of S-15176 Difumarate Salt on Ultrastructure and Functions of Liver Mitochondria of C57BL/6 Mice with Streptozotocin/High-Fat Diet-Induced Type 2 Diabetes
por: Belosludtseva, Natalia V., et al.
Publicado: (2020)

The Effect of Uridine on the State of Skeletal Muscles and the Functioning of Mitochondria in Duchenne Dystrophy
por: Dubinin, Mikhail V., et al.
Publicado: (2022)

Ultrastructural and Immunohistochemical Features of Telocytes in Placental Villi in Preeclampsia
por: Nizyaeva, Natalia V., et al.
Publicado: (2018)

Diabetes Mellitus, Mitochondrial Dysfunction and Ca(2+)-Dependent Permeability Transition Pore
por: Belosludtsev, Konstantin N., et al.
Publicado: (2020)

A protective role for N-acylphosphatidylethanolamine phospholipase D in 6-OHDA-induced neurodegeneration
por: Palese, Francesca, et al.
Publicado: (2019)

Palladium-catalyzed C–H olefination of uridine, deoxyuridine, uridine monophosphate and uridine analogues
por: Zhao, Qin, et al.
Publicado: (2022)

Behavioral, neural and ultrastructural alterations in a graded-dose 6-OHDA mouse model of early-stage Parkinson's disease
por: Slézia, Andrea, et al.
Publicado: (2023)

Indispensable residue for uridine binding in the uridine-cytidine kinase family
por: Tomoike, Fumiaki, et al.
Publicado: (2017)

Alterations in Mitochondrial Morphology and Quality Control in Primary Mouse Lung Microvascular Endothelial Cells and Human Dermal Fibroblasts under Hyperglycemic Conditions
por: Belosludtseva, Natalia V., et al.
Publicado: (2023)

Effect of the Non-Immunosuppressive MPT Pore Inhibitor Alisporivir on the Functioning of Heart Mitochondria in Dystrophin-Deficient mdx Mice
por: Dubinin, Mikhail V., et al.
Publicado: (2021)

Effect of uridine protecting groups on the diastereoselectivity of uridine-derived aldehyde 5’-alkynylation
por: Ben Othman, Raja, et al.
Publicado: (2017)

Mechanism of expanding the decoding capacity of tRNAs by modification of uridines
por: Weixlbaumer, Albert, et al.
Publicado: (2007)

Uridine Diphosphate Glucose (UDP-G) Activates Oxidative Stress and Respiratory Burst in Isolated Neutrophils
por: Lairion, Fabiana, et al.
Publicado: (2023)

Transport of Ca(2+) and Ca(2+)-Dependent Permeability Transition in Rat Liver Mitochondria under the Streptozotocin-Induced Type I Diabetes
por: Belosludtsev, Konstantin N., et al.
Publicado: (2019)

Alisporivir Normalizes Mitochondrial Function of Primary Mouse Lung Endothelial Cells Under Conditions of Hyperglycemia
por: Starinets, Vlada S., et al.
Publicado: (2022)

The Effect of Deflazacort Treatment on the Functioning of Skeletal Muscle Mitochondria in Duchenne Muscular Dystrophy
por: Dubinin, Mikhail V., et al.
Publicado: (2020)

Targeted inhibition of RAGE in substantia nigra of rats blocks 6-OHDA–induced dopaminergic denervation
por: Gasparotto, Juciano, et al.
Publicado: (2017)

Protocol for UVC uridine actinometry
por: Pousty, Dana, et al.
Publicado: (2022)

Alisporivir Improves Mitochondrial Function in Skeletal Muscle of mdx Mice but Suppresses Mitochondrial Dynamics and Biogenesis
por: Dubinin, Mikhail V., et al.
Publicado: (2021)

Alisporivir Treatment Alleviates Mitochondrial Dysfunction in the Skeletal Muscles of C57BL/6NCrl Mice with High-Fat Diet/Streptozotocin-Induced Diabetes Mellitus
por: Belosludtsev, Konstantin N., et al.
Publicado: (2021)

S-15176 Difumarate Salt Can Impair Mitochondrial Function through Inhibition of the Respiratory Complex III and Permeabilization of the Inner Mitochondrial Membrane
por: Belosludtseva, Natalia V., et al.
Publicado: (2022)

Effect of Modified Levopimaric Acid Diene Adducts on Mitochondrial and Liposome Membranes
por: Dubinin, Mikhail V., et al.
Publicado: (2022)

Cardio-Ankle Vascular Index in the Persons with Pre-Diabetes and Diabetes Mellitus in the Population Sample of the Russian Federation
por: Sumin, Alexei N., et al.
Publicado: (2021)

Impact of Aging on the 6-OHDA-Induced Rat Model of Parkinson’s Disease
por: Barata-Antunes, Sandra, et al.
Publicado: (2020)

Uridine Ameliorates Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice
por: Jeengar, Manish Kumar, et al.
Publicado: (2017)

Neuroprotective Effect of 1,4-Naphthoquinones in an In Vitro Model of Paraquat and 6-OHDA-Induced Neurotoxicity
por: Menchinskaya, Ekaterina, et al.
Publicado: (2021)

Visualization of the Nucleolus Using Ethynyl Uridine
por: Dvořáčková, Martina, et al.
Publicado: (2018)

Virome of Three Termite Species from Southern Vietnam
por: Litov, Alexander G., et al.
Publicado: (2022)

New Analogues of Uridine as Possible Anti-Viral Agents Specific to SARS-CoV-2
por: Maslova, A. A., et al.
Publicado: (2022)

Transport of Ca(2+) and Ca(2+)-Dependent Permeability Transition in the Liver and Heart Mitochondria of Rats with Different Tolerance to Acute Hypoxia
por: Belosludtsev, Konstantin N., et al.
Publicado: (2020)

Alterations of Coherent Theta and Gamma Network Oscillations as an Early Biomarker of Temporal Lobe Epilepsy and Alzheimer’s Disease
por: Kitchigina, Valentina F.
Publicado: (2018)

Theta Oscillations and Reactivity of Hippocampal Stratum Oriens Neurons
por: Kitchigina, Valentina F.
Publicado: (2010)

Protective effect of methanolic extract of Garcinia indica fruits in 6-OHDA rat model of Parkinson's disease
por: Antala, Bhaveshkumar V., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_rn5dsbunjkgno0mgl80rq9me93