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Identification of Glaucoma in Diabetics Using the Laguna-ONhE Colourimetric Method and OCT Spectralis

Background: Previous retrospective results are evaluated prospectively and blinded. Methods: A total of 221 eyes previously classified as normal (G1), 279 as moderate risk of glaucoma (G2) and 217 as high risk (G3) according to the Globin Discriminant Function (GDF) Laguna-ONhE index were examined w...

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Autores principales: Gonzalez-Hernandez, Marta, Betancor-Caro, Nisamar, Mesa-Lugo, Fatima, Rodriguez-Talavera, Ivan, Pareja-Rios, Alicia, Guedes-Guedes, Isabel, Estevez-Jorge, Beatriz, Trujillo-Blanco, Maricela, Cordova-Villegas, Roberto, Espinoza-Gonzalez, Juan, Siguero-Martin, Leticia, Goya-Gonzalez, Carolina, Rodriguez-Dominguez, Maria, Gonzalez-Hernandez, Daniel, Gonzalez de la Rosa, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531930/
https://www.ncbi.nlm.nih.gov/pubmed/37762816
http://dx.doi.org/10.3390/jcm12185876
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author Gonzalez-Hernandez, Marta
Betancor-Caro, Nisamar
Mesa-Lugo, Fatima
Rodriguez-Talavera, Ivan
Pareja-Rios, Alicia
Guedes-Guedes, Isabel
Estevez-Jorge, Beatriz
Trujillo-Blanco, Maricela
Cordova-Villegas, Roberto
Espinoza-Gonzalez, Juan
Siguero-Martin, Leticia
Goya-Gonzalez, Carolina
Rodriguez-Dominguez, Maria
Gonzalez-Hernandez, Daniel
Gonzalez de la Rosa, Manuel
author_facet Gonzalez-Hernandez, Marta
Betancor-Caro, Nisamar
Mesa-Lugo, Fatima
Rodriguez-Talavera, Ivan
Pareja-Rios, Alicia
Guedes-Guedes, Isabel
Estevez-Jorge, Beatriz
Trujillo-Blanco, Maricela
Cordova-Villegas, Roberto
Espinoza-Gonzalez, Juan
Siguero-Martin, Leticia
Goya-Gonzalez, Carolina
Rodriguez-Dominguez, Maria
Gonzalez-Hernandez, Daniel
Gonzalez de la Rosa, Manuel
author_sort Gonzalez-Hernandez, Marta
collection PubMed
description Background: Previous retrospective results are evaluated prospectively and blinded. Methods: A total of 221 eyes previously classified as normal (G1), 279 as moderate risk of glaucoma (G2) and 217 as high risk (G3) according to the Globin Discriminant Function (GDF) Laguna-ONhE index were examined with OCT Spectralis- Results: In G1, the Bruch’s Membrane Opening Minimum Rim Width (BMO-MRW) was 332 ± 55 microns; in G2, it was 252 ± 47 (p < 0.0001); and in G3, 231 ± 44 (p < 0.0001). In G1, the 1% and 5% percentiles were 233 and 248, respectively; in G2, they were lower in 28.80% and 42.29% of cases, respectively; and in G3, in 50.23% and 63.59% of cases, respectively. Most of the cases were normal-tension glaucomas. Laguna-ONhE indices showed a curvilinear correlation with BMO-MRW results. The Retinal Nerve Fibre Layer (RNFL) showed a poor relationship with BMO. Assuming G1 to be truly normal, BMO-MRW would have a Receiver operating characteristic (ROC) curve area of 0.901 for G2 and G3 and 0.651 for RNFL. A significant reduction in pixels corresponding to vessels was found in G2 and G3 vs. G1 (p < 0.0001). Conclusions: In some cases, these defects appear to be mainly glaucomatous, and in others, they are associated with diabetic microangiopathy. In normal tension glaucoma, RNFL defects may be less severe than those inside the nerve.
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spelling pubmed-105319302023-09-28 Identification of Glaucoma in Diabetics Using the Laguna-ONhE Colourimetric Method and OCT Spectralis Gonzalez-Hernandez, Marta Betancor-Caro, Nisamar Mesa-Lugo, Fatima Rodriguez-Talavera, Ivan Pareja-Rios, Alicia Guedes-Guedes, Isabel Estevez-Jorge, Beatriz Trujillo-Blanco, Maricela Cordova-Villegas, Roberto Espinoza-Gonzalez, Juan Siguero-Martin, Leticia Goya-Gonzalez, Carolina Rodriguez-Dominguez, Maria Gonzalez-Hernandez, Daniel Gonzalez de la Rosa, Manuel J Clin Med Article Background: Previous retrospective results are evaluated prospectively and blinded. Methods: A total of 221 eyes previously classified as normal (G1), 279 as moderate risk of glaucoma (G2) and 217 as high risk (G3) according to the Globin Discriminant Function (GDF) Laguna-ONhE index were examined with OCT Spectralis- Results: In G1, the Bruch’s Membrane Opening Minimum Rim Width (BMO-MRW) was 332 ± 55 microns; in G2, it was 252 ± 47 (p < 0.0001); and in G3, 231 ± 44 (p < 0.0001). In G1, the 1% and 5% percentiles were 233 and 248, respectively; in G2, they were lower in 28.80% and 42.29% of cases, respectively; and in G3, in 50.23% and 63.59% of cases, respectively. Most of the cases were normal-tension glaucomas. Laguna-ONhE indices showed a curvilinear correlation with BMO-MRW results. The Retinal Nerve Fibre Layer (RNFL) showed a poor relationship with BMO. Assuming G1 to be truly normal, BMO-MRW would have a Receiver operating characteristic (ROC) curve area of 0.901 for G2 and G3 and 0.651 for RNFL. A significant reduction in pixels corresponding to vessels was found in G2 and G3 vs. G1 (p < 0.0001). Conclusions: In some cases, these defects appear to be mainly glaucomatous, and in others, they are associated with diabetic microangiopathy. In normal tension glaucoma, RNFL defects may be less severe than those inside the nerve. MDPI 2023-09-10 /pmc/articles/PMC10531930/ /pubmed/37762816 http://dx.doi.org/10.3390/jcm12185876 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gonzalez-Hernandez, Marta
Betancor-Caro, Nisamar
Mesa-Lugo, Fatima
Rodriguez-Talavera, Ivan
Pareja-Rios, Alicia
Guedes-Guedes, Isabel
Estevez-Jorge, Beatriz
Trujillo-Blanco, Maricela
Cordova-Villegas, Roberto
Espinoza-Gonzalez, Juan
Siguero-Martin, Leticia
Goya-Gonzalez, Carolina
Rodriguez-Dominguez, Maria
Gonzalez-Hernandez, Daniel
Gonzalez de la Rosa, Manuel
Identification of Glaucoma in Diabetics Using the Laguna-ONhE Colourimetric Method and OCT Spectralis
title Identification of Glaucoma in Diabetics Using the Laguna-ONhE Colourimetric Method and OCT Spectralis
title_full Identification of Glaucoma in Diabetics Using the Laguna-ONhE Colourimetric Method and OCT Spectralis
title_fullStr Identification of Glaucoma in Diabetics Using the Laguna-ONhE Colourimetric Method and OCT Spectralis
title_full_unstemmed Identification of Glaucoma in Diabetics Using the Laguna-ONhE Colourimetric Method and OCT Spectralis
title_short Identification of Glaucoma in Diabetics Using the Laguna-ONhE Colourimetric Method and OCT Spectralis
title_sort identification of glaucoma in diabetics using the laguna-onhe colourimetric method and oct spectralis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531930/
https://www.ncbi.nlm.nih.gov/pubmed/37762816
http://dx.doi.org/10.3390/jcm12185876
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