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Identification of Glaucoma in Diabetics Using the Laguna-ONhE Colourimetric Method and OCT Spectralis
Background: Previous retrospective results are evaluated prospectively and blinded. Methods: A total of 221 eyes previously classified as normal (G1), 279 as moderate risk of glaucoma (G2) and 217 as high risk (G3) according to the Globin Discriminant Function (GDF) Laguna-ONhE index were examined w...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531930/ https://www.ncbi.nlm.nih.gov/pubmed/37762816 http://dx.doi.org/10.3390/jcm12185876 |
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author | Gonzalez-Hernandez, Marta Betancor-Caro, Nisamar Mesa-Lugo, Fatima Rodriguez-Talavera, Ivan Pareja-Rios, Alicia Guedes-Guedes, Isabel Estevez-Jorge, Beatriz Trujillo-Blanco, Maricela Cordova-Villegas, Roberto Espinoza-Gonzalez, Juan Siguero-Martin, Leticia Goya-Gonzalez, Carolina Rodriguez-Dominguez, Maria Gonzalez-Hernandez, Daniel Gonzalez de la Rosa, Manuel |
author_facet | Gonzalez-Hernandez, Marta Betancor-Caro, Nisamar Mesa-Lugo, Fatima Rodriguez-Talavera, Ivan Pareja-Rios, Alicia Guedes-Guedes, Isabel Estevez-Jorge, Beatriz Trujillo-Blanco, Maricela Cordova-Villegas, Roberto Espinoza-Gonzalez, Juan Siguero-Martin, Leticia Goya-Gonzalez, Carolina Rodriguez-Dominguez, Maria Gonzalez-Hernandez, Daniel Gonzalez de la Rosa, Manuel |
author_sort | Gonzalez-Hernandez, Marta |
collection | PubMed |
description | Background: Previous retrospective results are evaluated prospectively and blinded. Methods: A total of 221 eyes previously classified as normal (G1), 279 as moderate risk of glaucoma (G2) and 217 as high risk (G3) according to the Globin Discriminant Function (GDF) Laguna-ONhE index were examined with OCT Spectralis- Results: In G1, the Bruch’s Membrane Opening Minimum Rim Width (BMO-MRW) was 332 ± 55 microns; in G2, it was 252 ± 47 (p < 0.0001); and in G3, 231 ± 44 (p < 0.0001). In G1, the 1% and 5% percentiles were 233 and 248, respectively; in G2, they were lower in 28.80% and 42.29% of cases, respectively; and in G3, in 50.23% and 63.59% of cases, respectively. Most of the cases were normal-tension glaucomas. Laguna-ONhE indices showed a curvilinear correlation with BMO-MRW results. The Retinal Nerve Fibre Layer (RNFL) showed a poor relationship with BMO. Assuming G1 to be truly normal, BMO-MRW would have a Receiver operating characteristic (ROC) curve area of 0.901 for G2 and G3 and 0.651 for RNFL. A significant reduction in pixels corresponding to vessels was found in G2 and G3 vs. G1 (p < 0.0001). Conclusions: In some cases, these defects appear to be mainly glaucomatous, and in others, they are associated with diabetic microangiopathy. In normal tension glaucoma, RNFL defects may be less severe than those inside the nerve. |
format | Online Article Text |
id | pubmed-10531930 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105319302023-09-28 Identification of Glaucoma in Diabetics Using the Laguna-ONhE Colourimetric Method and OCT Spectralis Gonzalez-Hernandez, Marta Betancor-Caro, Nisamar Mesa-Lugo, Fatima Rodriguez-Talavera, Ivan Pareja-Rios, Alicia Guedes-Guedes, Isabel Estevez-Jorge, Beatriz Trujillo-Blanco, Maricela Cordova-Villegas, Roberto Espinoza-Gonzalez, Juan Siguero-Martin, Leticia Goya-Gonzalez, Carolina Rodriguez-Dominguez, Maria Gonzalez-Hernandez, Daniel Gonzalez de la Rosa, Manuel J Clin Med Article Background: Previous retrospective results are evaluated prospectively and blinded. Methods: A total of 221 eyes previously classified as normal (G1), 279 as moderate risk of glaucoma (G2) and 217 as high risk (G3) according to the Globin Discriminant Function (GDF) Laguna-ONhE index were examined with OCT Spectralis- Results: In G1, the Bruch’s Membrane Opening Minimum Rim Width (BMO-MRW) was 332 ± 55 microns; in G2, it was 252 ± 47 (p < 0.0001); and in G3, 231 ± 44 (p < 0.0001). In G1, the 1% and 5% percentiles were 233 and 248, respectively; in G2, they were lower in 28.80% and 42.29% of cases, respectively; and in G3, in 50.23% and 63.59% of cases, respectively. Most of the cases were normal-tension glaucomas. Laguna-ONhE indices showed a curvilinear correlation with BMO-MRW results. The Retinal Nerve Fibre Layer (RNFL) showed a poor relationship with BMO. Assuming G1 to be truly normal, BMO-MRW would have a Receiver operating characteristic (ROC) curve area of 0.901 for G2 and G3 and 0.651 for RNFL. A significant reduction in pixels corresponding to vessels was found in G2 and G3 vs. G1 (p < 0.0001). Conclusions: In some cases, these defects appear to be mainly glaucomatous, and in others, they are associated with diabetic microangiopathy. In normal tension glaucoma, RNFL defects may be less severe than those inside the nerve. MDPI 2023-09-10 /pmc/articles/PMC10531930/ /pubmed/37762816 http://dx.doi.org/10.3390/jcm12185876 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Gonzalez-Hernandez, Marta Betancor-Caro, Nisamar Mesa-Lugo, Fatima Rodriguez-Talavera, Ivan Pareja-Rios, Alicia Guedes-Guedes, Isabel Estevez-Jorge, Beatriz Trujillo-Blanco, Maricela Cordova-Villegas, Roberto Espinoza-Gonzalez, Juan Siguero-Martin, Leticia Goya-Gonzalez, Carolina Rodriguez-Dominguez, Maria Gonzalez-Hernandez, Daniel Gonzalez de la Rosa, Manuel Identification of Glaucoma in Diabetics Using the Laguna-ONhE Colourimetric Method and OCT Spectralis |
title | Identification of Glaucoma in Diabetics Using the Laguna-ONhE Colourimetric Method and OCT Spectralis |
title_full | Identification of Glaucoma in Diabetics Using the Laguna-ONhE Colourimetric Method and OCT Spectralis |
title_fullStr | Identification of Glaucoma in Diabetics Using the Laguna-ONhE Colourimetric Method and OCT Spectralis |
title_full_unstemmed | Identification of Glaucoma in Diabetics Using the Laguna-ONhE Colourimetric Method and OCT Spectralis |
title_short | Identification of Glaucoma in Diabetics Using the Laguna-ONhE Colourimetric Method and OCT Spectralis |
title_sort | identification of glaucoma in diabetics using the laguna-onhe colourimetric method and oct spectralis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531930/ https://www.ncbi.nlm.nih.gov/pubmed/37762816 http://dx.doi.org/10.3390/jcm12185876 |
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