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Cellulose/Zeolitic Imidazolate Framework (ZIF-8) Composites with Antibacterial Properties for the Management of Wound Infections

Metal–organic frameworks (MOFs) are a class of crystalline porous materials with outstanding physical and chemical properties that make them suitable candidates in many fields, such as catalysis, sensing, energy production, and drug delivery. By combining MOFs with polymeric substrates, advanced fun...

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Autores principales: Di Matteo, Valentina, Di Filippo, Maria Francesca, Ballarin, Barbara, Gentilomi, Giovanna Angela, Bonvicini, Francesca, Panzavolta, Silvia, Cassani, Maria Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532010/
https://www.ncbi.nlm.nih.gov/pubmed/37754886
http://dx.doi.org/10.3390/jfb14090472
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author Di Matteo, Valentina
Di Filippo, Maria Francesca
Ballarin, Barbara
Gentilomi, Giovanna Angela
Bonvicini, Francesca
Panzavolta, Silvia
Cassani, Maria Cristina
author_facet Di Matteo, Valentina
Di Filippo, Maria Francesca
Ballarin, Barbara
Gentilomi, Giovanna Angela
Bonvicini, Francesca
Panzavolta, Silvia
Cassani, Maria Cristina
author_sort Di Matteo, Valentina
collection PubMed
description Metal–organic frameworks (MOFs) are a class of crystalline porous materials with outstanding physical and chemical properties that make them suitable candidates in many fields, such as catalysis, sensing, energy production, and drug delivery. By combining MOFs with polymeric substrates, advanced functional materials are devised with excellent potential for biomedical applications. In this research, Zeolitic Imidazolate Framework 8 (ZIF-8), a zinc-based MOF, was selected together with cellulose, an almost inexhaustible polymeric raw material produced by nature, to prepare cellulose/ZIF-8 composite flat sheets via an in-situ growing single-step method in aqueous media. The composite materials were characterized by several techniques (IR, XRD, SEM, TGA, ICP, and BET) and their antibacterial activity as well as their biocompatibility in a mammalian model system were investigated. The cellulose/ZIF-8 samples remarkably inhibited the growth of Gram-positive and Gram-negative reference strains, and, notably, they proved to be effective against clinical isolates of Staphylococcus epidermidis and Pseudomonas aeruginosa presenting different antibiotic resistance profiles. As these pathogens are of primary importance in skin diseases and in the delayed healing of wounds, and the cellulose/ZIF-8 composites met the requirements of biological safety, the herein materials reveal a great potential for use as gauze pads in the management of wound infections.
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spelling pubmed-105320102023-09-28 Cellulose/Zeolitic Imidazolate Framework (ZIF-8) Composites with Antibacterial Properties for the Management of Wound Infections Di Matteo, Valentina Di Filippo, Maria Francesca Ballarin, Barbara Gentilomi, Giovanna Angela Bonvicini, Francesca Panzavolta, Silvia Cassani, Maria Cristina J Funct Biomater Article Metal–organic frameworks (MOFs) are a class of crystalline porous materials with outstanding physical and chemical properties that make them suitable candidates in many fields, such as catalysis, sensing, energy production, and drug delivery. By combining MOFs with polymeric substrates, advanced functional materials are devised with excellent potential for biomedical applications. In this research, Zeolitic Imidazolate Framework 8 (ZIF-8), a zinc-based MOF, was selected together with cellulose, an almost inexhaustible polymeric raw material produced by nature, to prepare cellulose/ZIF-8 composite flat sheets via an in-situ growing single-step method in aqueous media. The composite materials were characterized by several techniques (IR, XRD, SEM, TGA, ICP, and BET) and their antibacterial activity as well as their biocompatibility in a mammalian model system were investigated. The cellulose/ZIF-8 samples remarkably inhibited the growth of Gram-positive and Gram-negative reference strains, and, notably, they proved to be effective against clinical isolates of Staphylococcus epidermidis and Pseudomonas aeruginosa presenting different antibiotic resistance profiles. As these pathogens are of primary importance in skin diseases and in the delayed healing of wounds, and the cellulose/ZIF-8 composites met the requirements of biological safety, the herein materials reveal a great potential for use as gauze pads in the management of wound infections. MDPI 2023-09-13 /pmc/articles/PMC10532010/ /pubmed/37754886 http://dx.doi.org/10.3390/jfb14090472 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Di Matteo, Valentina
Di Filippo, Maria Francesca
Ballarin, Barbara
Gentilomi, Giovanna Angela
Bonvicini, Francesca
Panzavolta, Silvia
Cassani, Maria Cristina
Cellulose/Zeolitic Imidazolate Framework (ZIF-8) Composites with Antibacterial Properties for the Management of Wound Infections
title Cellulose/Zeolitic Imidazolate Framework (ZIF-8) Composites with Antibacterial Properties for the Management of Wound Infections
title_full Cellulose/Zeolitic Imidazolate Framework (ZIF-8) Composites with Antibacterial Properties for the Management of Wound Infections
title_fullStr Cellulose/Zeolitic Imidazolate Framework (ZIF-8) Composites with Antibacterial Properties for the Management of Wound Infections
title_full_unstemmed Cellulose/Zeolitic Imidazolate Framework (ZIF-8) Composites with Antibacterial Properties for the Management of Wound Infections
title_short Cellulose/Zeolitic Imidazolate Framework (ZIF-8) Composites with Antibacterial Properties for the Management of Wound Infections
title_sort cellulose/zeolitic imidazolate framework (zif-8) composites with antibacterial properties for the management of wound infections
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532010/
https://www.ncbi.nlm.nih.gov/pubmed/37754886
http://dx.doi.org/10.3390/jfb14090472
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