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Electrospun Scaffolds as Antimicrobial Herbal Extract Delivery Vehicles for Wound Healing

Herbal extracts have been used in traditional remedies since the earliest myths. They have excellent antimicrobial, anti-inflammatory, and antioxidant activities owing to various bioactive components in their structure. However, due to their inability to reach a target and low biostability, their us...

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Autores principales: Ersanli, Caglar, Voidarou, Chrysoula (Chrysa), Tzora, Athina, Fotou, Konstantina, Zeugolis, Dimitrios I., Skoufos, Ioannis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532143/
https://www.ncbi.nlm.nih.gov/pubmed/37754895
http://dx.doi.org/10.3390/jfb14090481
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author Ersanli, Caglar
Voidarou, Chrysoula (Chrysa)
Tzora, Athina
Fotou, Konstantina
Zeugolis, Dimitrios I.
Skoufos, Ioannis
author_facet Ersanli, Caglar
Voidarou, Chrysoula (Chrysa)
Tzora, Athina
Fotou, Konstantina
Zeugolis, Dimitrios I.
Skoufos, Ioannis
author_sort Ersanli, Caglar
collection PubMed
description Herbal extracts have been used in traditional remedies since the earliest myths. They have excellent antimicrobial, anti-inflammatory, and antioxidant activities owing to various bioactive components in their structure. However, due to their inability to reach a target and low biostability, their use with a delivery vehicle has come into prominence. For this purpose, electrospun nanofibrous scaffolds have been widely preferred for the delivery and release of antimicrobial herbal extracts due to the flexibility and operational versatility of the electrospinning technique. Herein, we briefly reviewed the electrospun nanofibrous scaffolds as delivery systems for herbal extracts with a particular focus on the preclinical studies for wound-healing applications that have been published in the last five years. We also discussed the indirect effects of herbal extracts on wound healing by altering the characteristics of electrospun mats.
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spelling pubmed-105321432023-09-28 Electrospun Scaffolds as Antimicrobial Herbal Extract Delivery Vehicles for Wound Healing Ersanli, Caglar Voidarou, Chrysoula (Chrysa) Tzora, Athina Fotou, Konstantina Zeugolis, Dimitrios I. Skoufos, Ioannis J Funct Biomater Opinion Herbal extracts have been used in traditional remedies since the earliest myths. They have excellent antimicrobial, anti-inflammatory, and antioxidant activities owing to various bioactive components in their structure. However, due to their inability to reach a target and low biostability, their use with a delivery vehicle has come into prominence. For this purpose, electrospun nanofibrous scaffolds have been widely preferred for the delivery and release of antimicrobial herbal extracts due to the flexibility and operational versatility of the electrospinning technique. Herein, we briefly reviewed the electrospun nanofibrous scaffolds as delivery systems for herbal extracts with a particular focus on the preclinical studies for wound-healing applications that have been published in the last five years. We also discussed the indirect effects of herbal extracts on wound healing by altering the characteristics of electrospun mats. MDPI 2023-09-19 /pmc/articles/PMC10532143/ /pubmed/37754895 http://dx.doi.org/10.3390/jfb14090481 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Opinion
Ersanli, Caglar
Voidarou, Chrysoula (Chrysa)
Tzora, Athina
Fotou, Konstantina
Zeugolis, Dimitrios I.
Skoufos, Ioannis
Electrospun Scaffolds as Antimicrobial Herbal Extract Delivery Vehicles for Wound Healing
title Electrospun Scaffolds as Antimicrobial Herbal Extract Delivery Vehicles for Wound Healing
title_full Electrospun Scaffolds as Antimicrobial Herbal Extract Delivery Vehicles for Wound Healing
title_fullStr Electrospun Scaffolds as Antimicrobial Herbal Extract Delivery Vehicles for Wound Healing
title_full_unstemmed Electrospun Scaffolds as Antimicrobial Herbal Extract Delivery Vehicles for Wound Healing
title_short Electrospun Scaffolds as Antimicrobial Herbal Extract Delivery Vehicles for Wound Healing
title_sort electrospun scaffolds as antimicrobial herbal extract delivery vehicles for wound healing
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532143/
https://www.ncbi.nlm.nih.gov/pubmed/37754895
http://dx.doi.org/10.3390/jfb14090481
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