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Advanced Anterior Eye Segment Imaging for Ichthyosis

The purpose of this study was to describe ocular surface and anterior eye segment findings in various types of ichthyoses. Methods: This was a single-center prospective observational study. The study group consisted of five patients (P1–P5) aged 13–66 years. Multimodal imaging was performed, includi...

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Autores principales: Micińska, Anna, Nowińska, Anna, Teper, Sławomir, Kokot-Lesik, Joanna, Wylęgała, Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532152/
https://www.ncbi.nlm.nih.gov/pubmed/37762949
http://dx.doi.org/10.3390/jcm12186006
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author Micińska, Anna
Nowińska, Anna
Teper, Sławomir
Kokot-Lesik, Joanna
Wylęgała, Edward
author_facet Micińska, Anna
Nowińska, Anna
Teper, Sławomir
Kokot-Lesik, Joanna
Wylęgała, Edward
author_sort Micińska, Anna
collection PubMed
description The purpose of this study was to describe ocular surface and anterior eye segment findings in various types of ichthyoses. Methods: This was a single-center prospective observational study. The study group consisted of five patients (P1–P5) aged 13–66 years. Multimodal imaging was performed, including slit-lamp examinations, swept-source optical coherence tomography (SS-OCT), and in vivo confocal microscopy (IVCM). Results: All patients were diagnosed with moderate-to-severe dry eye disease (DED). The corneas showed a significant pattern of irregularity, with a significant difference between the corneal thickness at the apex (CAT) and the corneal thinnest thickness (CTT), exceeding 375 µm. Three patients were diagnosed with ectasia patterns based on SS-OCT. All patients showed abnormalities in at least one Fourier index parameter for at least one eye at 3 or 6 mm in the keratometric, anterior, or posterior analyses. IVCM examinations revealed changes in all corneal layers. Conclusions: By combining the results of multimodal imaging, we were able to detect preclinical abnormalities, distinguish characteristic changes common to ichthyosis, and reveal the depth and characteristics of corneal abnormalities. Therefore, patients with ichthyosis should be examined for DED and ectatic disorders early in clinical practice.
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spelling pubmed-105321522023-09-28 Advanced Anterior Eye Segment Imaging for Ichthyosis Micińska, Anna Nowińska, Anna Teper, Sławomir Kokot-Lesik, Joanna Wylęgała, Edward J Clin Med Article The purpose of this study was to describe ocular surface and anterior eye segment findings in various types of ichthyoses. Methods: This was a single-center prospective observational study. The study group consisted of five patients (P1–P5) aged 13–66 years. Multimodal imaging was performed, including slit-lamp examinations, swept-source optical coherence tomography (SS-OCT), and in vivo confocal microscopy (IVCM). Results: All patients were diagnosed with moderate-to-severe dry eye disease (DED). The corneas showed a significant pattern of irregularity, with a significant difference between the corneal thickness at the apex (CAT) and the corneal thinnest thickness (CTT), exceeding 375 µm. Three patients were diagnosed with ectasia patterns based on SS-OCT. All patients showed abnormalities in at least one Fourier index parameter for at least one eye at 3 or 6 mm in the keratometric, anterior, or posterior analyses. IVCM examinations revealed changes in all corneal layers. Conclusions: By combining the results of multimodal imaging, we were able to detect preclinical abnormalities, distinguish characteristic changes common to ichthyosis, and reveal the depth and characteristics of corneal abnormalities. Therefore, patients with ichthyosis should be examined for DED and ectatic disorders early in clinical practice. MDPI 2023-09-16 /pmc/articles/PMC10532152/ /pubmed/37762949 http://dx.doi.org/10.3390/jcm12186006 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Micińska, Anna
Nowińska, Anna
Teper, Sławomir
Kokot-Lesik, Joanna
Wylęgała, Edward
Advanced Anterior Eye Segment Imaging for Ichthyosis
title Advanced Anterior Eye Segment Imaging for Ichthyosis
title_full Advanced Anterior Eye Segment Imaging for Ichthyosis
title_fullStr Advanced Anterior Eye Segment Imaging for Ichthyosis
title_full_unstemmed Advanced Anterior Eye Segment Imaging for Ichthyosis
title_short Advanced Anterior Eye Segment Imaging for Ichthyosis
title_sort advanced anterior eye segment imaging for ichthyosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532152/
https://www.ncbi.nlm.nih.gov/pubmed/37762949
http://dx.doi.org/10.3390/jcm12186006
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