The Diagnostic, Prognostic, and Therapeutic Potential of Cell-Free DNA with a Special Focus on COVID-19 and Other Viral Infections

Cell-free DNA (cfDNA) in human blood serum, urine, and other body fluids recently became a commonly used diagnostic marker associated with various pathologies. This is because cfDNA enables a much higher sensitivity than standard biochemical parameters. The presence of and/or increased level of cfDN...

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Autores principales: Hovhannisyan, Galina, Harutyunyan, Tigran, Aroutiounian, Rouben, Liehr, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532175/
https://www.ncbi.nlm.nih.gov/pubmed/37762464
http://dx.doi.org/10.3390/ijms241814163
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author Hovhannisyan, Galina
Harutyunyan, Tigran
Aroutiounian, Rouben
Liehr, Thomas
author_facet Hovhannisyan, Galina
Harutyunyan, Tigran
Aroutiounian, Rouben
Liehr, Thomas
author_sort Hovhannisyan, Galina
collection PubMed
description Cell-free DNA (cfDNA) in human blood serum, urine, and other body fluids recently became a commonly used diagnostic marker associated with various pathologies. This is because cfDNA enables a much higher sensitivity than standard biochemical parameters. The presence of and/or increased level of cfDNA has been reported for various diseases, including viral infections, including COVID-19. Here, we review cfDNA in general, how it has been identified, where it can derive from, its molecular features, and mechanisms of release and clearance. General suitability of cfDNA for diagnostic questions, possible shortcomings and future directions are discussed, with a special focus on coronavirus infection.
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spelling pubmed-105321752023-09-28 The Diagnostic, Prognostic, and Therapeutic Potential of Cell-Free DNA with a Special Focus on COVID-19 and Other Viral Infections Hovhannisyan, Galina Harutyunyan, Tigran Aroutiounian, Rouben Liehr, Thomas Int J Mol Sci Review Cell-free DNA (cfDNA) in human blood serum, urine, and other body fluids recently became a commonly used diagnostic marker associated with various pathologies. This is because cfDNA enables a much higher sensitivity than standard biochemical parameters. The presence of and/or increased level of cfDNA has been reported for various diseases, including viral infections, including COVID-19. Here, we review cfDNA in general, how it has been identified, where it can derive from, its molecular features, and mechanisms of release and clearance. General suitability of cfDNA for diagnostic questions, possible shortcomings and future directions are discussed, with a special focus on coronavirus infection. MDPI 2023-09-15 /pmc/articles/PMC10532175/ /pubmed/37762464 http://dx.doi.org/10.3390/ijms241814163 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hovhannisyan, Galina
Harutyunyan, Tigran
Aroutiounian, Rouben
Liehr, Thomas
The Diagnostic, Prognostic, and Therapeutic Potential of Cell-Free DNA with a Special Focus on COVID-19 and Other Viral Infections
title The Diagnostic, Prognostic, and Therapeutic Potential of Cell-Free DNA with a Special Focus on COVID-19 and Other Viral Infections
title_full The Diagnostic, Prognostic, and Therapeutic Potential of Cell-Free DNA with a Special Focus on COVID-19 and Other Viral Infections
title_fullStr The Diagnostic, Prognostic, and Therapeutic Potential of Cell-Free DNA with a Special Focus on COVID-19 and Other Viral Infections
title_full_unstemmed The Diagnostic, Prognostic, and Therapeutic Potential of Cell-Free DNA with a Special Focus on COVID-19 and Other Viral Infections
title_short The Diagnostic, Prognostic, and Therapeutic Potential of Cell-Free DNA with a Special Focus on COVID-19 and Other Viral Infections
title_sort diagnostic, prognostic, and therapeutic potential of cell-free dna with a special focus on covid-19 and other viral infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532175/
https://www.ncbi.nlm.nih.gov/pubmed/37762464
http://dx.doi.org/10.3390/ijms241814163
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