Cargando…

Design and Harmonization Approach for the Multi-Institutional Neurocognitive Discovery Study (MINDS) of Adult Congenital Heart Disease (ACHD) Neuroimaging Ancillary Study: A Technical Note

Dramatic advances in the management of congenital heart disease (CHD) have improved survival to adulthood from less than 10% in the 1960s to over 90% in the current era, such that adult CHD (ACHD) patients now outnumber their pediatric counterparts. ACHD patients demonstrate domain-specific neurocog...

Descripción completa

Detalles Bibliográficos
Autores principales: Panigrahy, Ashok, Schmithorst, Vanessa, Ceschin, Rafael, Lee, Vince, Beluk, Nancy, Wallace, Julia, Wheaton, Olivia, Chenevert, Thomas, Qiu, Deqiang, Lee, James N, Nencka, Andrew, Gagoski, Borjan, Berman, Jeffrey I., Yuan, Weihong, Macgowan, Christopher, Coatsworth, James, Fleysher, Lazar, Cannistraci, Christopher, Sleeper, Lynn A., Hoskoppal, Arvind, Silversides, Candice, Radhakrishnan, Rupa, Markham, Larry, Rhodes, John F., Dugan, Lauryn M., Brown, Nicole, Ermis, Peter, Fuller, Stephanie, Cotts, Timothy Brett, Rodriguez, Fred Henry, Lindsay, Ian, Beers, Sue, Aizenstein, Howard, Bellinger, David C., Newburger, Jane W., Umfleet, Laura Glass, Cohen, Scott, Zaidi, Ali, Gurvitz, Michelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532244/
https://www.ncbi.nlm.nih.gov/pubmed/37754810
http://dx.doi.org/10.3390/jcdd10090381
_version_ 1785111910292652032
author Panigrahy, Ashok
Schmithorst, Vanessa
Ceschin, Rafael
Lee, Vince
Beluk, Nancy
Wallace, Julia
Wheaton, Olivia
Chenevert, Thomas
Qiu, Deqiang
Lee, James N
Nencka, Andrew
Gagoski, Borjan
Berman, Jeffrey I.
Yuan, Weihong
Macgowan, Christopher
Coatsworth, James
Fleysher, Lazar
Cannistraci, Christopher
Sleeper, Lynn A.
Hoskoppal, Arvind
Silversides, Candice
Radhakrishnan, Rupa
Markham, Larry
Rhodes, John F.
Dugan, Lauryn M.
Brown, Nicole
Ermis, Peter
Fuller, Stephanie
Cotts, Timothy Brett
Rodriguez, Fred Henry
Lindsay, Ian
Beers, Sue
Aizenstein, Howard
Bellinger, David C.
Newburger, Jane W.
Umfleet, Laura Glass
Cohen, Scott
Zaidi, Ali
Gurvitz, Michelle
author_facet Panigrahy, Ashok
Schmithorst, Vanessa
Ceschin, Rafael
Lee, Vince
Beluk, Nancy
Wallace, Julia
Wheaton, Olivia
Chenevert, Thomas
Qiu, Deqiang
Lee, James N
Nencka, Andrew
Gagoski, Borjan
Berman, Jeffrey I.
Yuan, Weihong
Macgowan, Christopher
Coatsworth, James
Fleysher, Lazar
Cannistraci, Christopher
Sleeper, Lynn A.
Hoskoppal, Arvind
Silversides, Candice
Radhakrishnan, Rupa
Markham, Larry
Rhodes, John F.
Dugan, Lauryn M.
Brown, Nicole
Ermis, Peter
Fuller, Stephanie
Cotts, Timothy Brett
Rodriguez, Fred Henry
Lindsay, Ian
Beers, Sue
Aizenstein, Howard
Bellinger, David C.
Newburger, Jane W.
Umfleet, Laura Glass
Cohen, Scott
Zaidi, Ali
Gurvitz, Michelle
author_sort Panigrahy, Ashok
collection PubMed
description Dramatic advances in the management of congenital heart disease (CHD) have improved survival to adulthood from less than 10% in the 1960s to over 90% in the current era, such that adult CHD (ACHD) patients now outnumber their pediatric counterparts. ACHD patients demonstrate domain-specific neurocognitive deficits associated with reduced quality of life that include deficits in educational attainment and social interaction. Our hypothesis is that ACHD patients exhibit vascular brain injury and structural/physiological brain alterations that are predictive of specific neurocognitive deficits modified by behavioral and environmental enrichment proxies of cognitive reserve (e.g., level of education and lifestyle/social habits). This technical note describes an ancillary study to the National Heart, Lung, and Blood Institute (NHLBI)-funded Pediatric Heart Network (PHN) “Multi-Institutional Neurocognitive Discovery Study (MINDS) in Adult Congenital Heart Disease (ACHD)”. Leveraging clinical, neuropsychological, and biospecimen data from the parent study, our study will provide structural–physiological correlates of neurocognitive outcomes, representing the first multi-center neuroimaging initiative to be performed in ACHD patients. Limitations of the study include recruitment challenges inherent to an ancillary study, implantable cardiac devices, and harmonization of neuroimaging biomarkers. Results from this research will help shape the care of ACHD patients and further our understanding of the interplay between brain injury and cognitive reserve.
format Online
Article
Text
id pubmed-10532244
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-105322442023-09-28 Design and Harmonization Approach for the Multi-Institutional Neurocognitive Discovery Study (MINDS) of Adult Congenital Heart Disease (ACHD) Neuroimaging Ancillary Study: A Technical Note Panigrahy, Ashok Schmithorst, Vanessa Ceschin, Rafael Lee, Vince Beluk, Nancy Wallace, Julia Wheaton, Olivia Chenevert, Thomas Qiu, Deqiang Lee, James N Nencka, Andrew Gagoski, Borjan Berman, Jeffrey I. Yuan, Weihong Macgowan, Christopher Coatsworth, James Fleysher, Lazar Cannistraci, Christopher Sleeper, Lynn A. Hoskoppal, Arvind Silversides, Candice Radhakrishnan, Rupa Markham, Larry Rhodes, John F. Dugan, Lauryn M. Brown, Nicole Ermis, Peter Fuller, Stephanie Cotts, Timothy Brett Rodriguez, Fred Henry Lindsay, Ian Beers, Sue Aizenstein, Howard Bellinger, David C. Newburger, Jane W. Umfleet, Laura Glass Cohen, Scott Zaidi, Ali Gurvitz, Michelle J Cardiovasc Dev Dis Technical Note Dramatic advances in the management of congenital heart disease (CHD) have improved survival to adulthood from less than 10% in the 1960s to over 90% in the current era, such that adult CHD (ACHD) patients now outnumber their pediatric counterparts. ACHD patients demonstrate domain-specific neurocognitive deficits associated with reduced quality of life that include deficits in educational attainment and social interaction. Our hypothesis is that ACHD patients exhibit vascular brain injury and structural/physiological brain alterations that are predictive of specific neurocognitive deficits modified by behavioral and environmental enrichment proxies of cognitive reserve (e.g., level of education and lifestyle/social habits). This technical note describes an ancillary study to the National Heart, Lung, and Blood Institute (NHLBI)-funded Pediatric Heart Network (PHN) “Multi-Institutional Neurocognitive Discovery Study (MINDS) in Adult Congenital Heart Disease (ACHD)”. Leveraging clinical, neuropsychological, and biospecimen data from the parent study, our study will provide structural–physiological correlates of neurocognitive outcomes, representing the first multi-center neuroimaging initiative to be performed in ACHD patients. Limitations of the study include recruitment challenges inherent to an ancillary study, implantable cardiac devices, and harmonization of neuroimaging biomarkers. Results from this research will help shape the care of ACHD patients and further our understanding of the interplay between brain injury and cognitive reserve. MDPI 2023-09-06 /pmc/articles/PMC10532244/ /pubmed/37754810 http://dx.doi.org/10.3390/jcdd10090381 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Technical Note
Panigrahy, Ashok
Schmithorst, Vanessa
Ceschin, Rafael
Lee, Vince
Beluk, Nancy
Wallace, Julia
Wheaton, Olivia
Chenevert, Thomas
Qiu, Deqiang
Lee, James N
Nencka, Andrew
Gagoski, Borjan
Berman, Jeffrey I.
Yuan, Weihong
Macgowan, Christopher
Coatsworth, James
Fleysher, Lazar
Cannistraci, Christopher
Sleeper, Lynn A.
Hoskoppal, Arvind
Silversides, Candice
Radhakrishnan, Rupa
Markham, Larry
Rhodes, John F.
Dugan, Lauryn M.
Brown, Nicole
Ermis, Peter
Fuller, Stephanie
Cotts, Timothy Brett
Rodriguez, Fred Henry
Lindsay, Ian
Beers, Sue
Aizenstein, Howard
Bellinger, David C.
Newburger, Jane W.
Umfleet, Laura Glass
Cohen, Scott
Zaidi, Ali
Gurvitz, Michelle
Design and Harmonization Approach for the Multi-Institutional Neurocognitive Discovery Study (MINDS) of Adult Congenital Heart Disease (ACHD) Neuroimaging Ancillary Study: A Technical Note
title Design and Harmonization Approach for the Multi-Institutional Neurocognitive Discovery Study (MINDS) of Adult Congenital Heart Disease (ACHD) Neuroimaging Ancillary Study: A Technical Note
title_full Design and Harmonization Approach for the Multi-Institutional Neurocognitive Discovery Study (MINDS) of Adult Congenital Heart Disease (ACHD) Neuroimaging Ancillary Study: A Technical Note
title_fullStr Design and Harmonization Approach for the Multi-Institutional Neurocognitive Discovery Study (MINDS) of Adult Congenital Heart Disease (ACHD) Neuroimaging Ancillary Study: A Technical Note
title_full_unstemmed Design and Harmonization Approach for the Multi-Institutional Neurocognitive Discovery Study (MINDS) of Adult Congenital Heart Disease (ACHD) Neuroimaging Ancillary Study: A Technical Note
title_short Design and Harmonization Approach for the Multi-Institutional Neurocognitive Discovery Study (MINDS) of Adult Congenital Heart Disease (ACHD) Neuroimaging Ancillary Study: A Technical Note
title_sort design and harmonization approach for the multi-institutional neurocognitive discovery study (minds) of adult congenital heart disease (achd) neuroimaging ancillary study: a technical note
topic Technical Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532244/
https://www.ncbi.nlm.nih.gov/pubmed/37754810
http://dx.doi.org/10.3390/jcdd10090381
work_keys_str_mv AT panigrahyashok designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT schmithorstvanessa designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT ceschinrafael designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT leevince designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT beluknancy designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT wallacejulia designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT wheatonolivia designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT chenevertthomas designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT qiudeqiang designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT leejamesn designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT nenckaandrew designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT gagoskiborjan designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT bermanjeffreyi designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT yuanweihong designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT macgowanchristopher designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT coatsworthjames designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT fleysherlazar designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT cannistracichristopher designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT sleeperlynna designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT hoskoppalarvind designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT silversidescandice designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT radhakrishnanrupa designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT markhamlarry designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT rhodesjohnf designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT duganlaurynm designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT brownnicole designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT ermispeter designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT fullerstephanie designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT cottstimothybrett designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT rodriguezfredhenry designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT lindsayian designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT beerssue designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT aizensteinhoward designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT bellingerdavidc designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT newburgerjanew designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT umfleetlauraglass designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT cohenscott designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT zaidiali designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote
AT gurvitzmichelle designandharmonizationapproachforthemultiinstitutionalneurocognitivediscoverystudymindsofadultcongenitalheartdiseaseachdneuroimagingancillarystudyatechnicalnote