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Design and Harmonization Approach for the Multi-Institutional Neurocognitive Discovery Study (MINDS) of Adult Congenital Heart Disease (ACHD) Neuroimaging Ancillary Study: A Technical Note
Dramatic advances in the management of congenital heart disease (CHD) have improved survival to adulthood from less than 10% in the 1960s to over 90% in the current era, such that adult CHD (ACHD) patients now outnumber their pediatric counterparts. ACHD patients demonstrate domain-specific neurocog...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532244/ https://www.ncbi.nlm.nih.gov/pubmed/37754810 http://dx.doi.org/10.3390/jcdd10090381 |
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author | Panigrahy, Ashok Schmithorst, Vanessa Ceschin, Rafael Lee, Vince Beluk, Nancy Wallace, Julia Wheaton, Olivia Chenevert, Thomas Qiu, Deqiang Lee, James N Nencka, Andrew Gagoski, Borjan Berman, Jeffrey I. Yuan, Weihong Macgowan, Christopher Coatsworth, James Fleysher, Lazar Cannistraci, Christopher Sleeper, Lynn A. Hoskoppal, Arvind Silversides, Candice Radhakrishnan, Rupa Markham, Larry Rhodes, John F. Dugan, Lauryn M. Brown, Nicole Ermis, Peter Fuller, Stephanie Cotts, Timothy Brett Rodriguez, Fred Henry Lindsay, Ian Beers, Sue Aizenstein, Howard Bellinger, David C. Newburger, Jane W. Umfleet, Laura Glass Cohen, Scott Zaidi, Ali Gurvitz, Michelle |
author_facet | Panigrahy, Ashok Schmithorst, Vanessa Ceschin, Rafael Lee, Vince Beluk, Nancy Wallace, Julia Wheaton, Olivia Chenevert, Thomas Qiu, Deqiang Lee, James N Nencka, Andrew Gagoski, Borjan Berman, Jeffrey I. Yuan, Weihong Macgowan, Christopher Coatsworth, James Fleysher, Lazar Cannistraci, Christopher Sleeper, Lynn A. Hoskoppal, Arvind Silversides, Candice Radhakrishnan, Rupa Markham, Larry Rhodes, John F. Dugan, Lauryn M. Brown, Nicole Ermis, Peter Fuller, Stephanie Cotts, Timothy Brett Rodriguez, Fred Henry Lindsay, Ian Beers, Sue Aizenstein, Howard Bellinger, David C. Newburger, Jane W. Umfleet, Laura Glass Cohen, Scott Zaidi, Ali Gurvitz, Michelle |
author_sort | Panigrahy, Ashok |
collection | PubMed |
description | Dramatic advances in the management of congenital heart disease (CHD) have improved survival to adulthood from less than 10% in the 1960s to over 90% in the current era, such that adult CHD (ACHD) patients now outnumber their pediatric counterparts. ACHD patients demonstrate domain-specific neurocognitive deficits associated with reduced quality of life that include deficits in educational attainment and social interaction. Our hypothesis is that ACHD patients exhibit vascular brain injury and structural/physiological brain alterations that are predictive of specific neurocognitive deficits modified by behavioral and environmental enrichment proxies of cognitive reserve (e.g., level of education and lifestyle/social habits). This technical note describes an ancillary study to the National Heart, Lung, and Blood Institute (NHLBI)-funded Pediatric Heart Network (PHN) “Multi-Institutional Neurocognitive Discovery Study (MINDS) in Adult Congenital Heart Disease (ACHD)”. Leveraging clinical, neuropsychological, and biospecimen data from the parent study, our study will provide structural–physiological correlates of neurocognitive outcomes, representing the first multi-center neuroimaging initiative to be performed in ACHD patients. Limitations of the study include recruitment challenges inherent to an ancillary study, implantable cardiac devices, and harmonization of neuroimaging biomarkers. Results from this research will help shape the care of ACHD patients and further our understanding of the interplay between brain injury and cognitive reserve. |
format | Online Article Text |
id | pubmed-10532244 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105322442023-09-28 Design and Harmonization Approach for the Multi-Institutional Neurocognitive Discovery Study (MINDS) of Adult Congenital Heart Disease (ACHD) Neuroimaging Ancillary Study: A Technical Note Panigrahy, Ashok Schmithorst, Vanessa Ceschin, Rafael Lee, Vince Beluk, Nancy Wallace, Julia Wheaton, Olivia Chenevert, Thomas Qiu, Deqiang Lee, James N Nencka, Andrew Gagoski, Borjan Berman, Jeffrey I. Yuan, Weihong Macgowan, Christopher Coatsworth, James Fleysher, Lazar Cannistraci, Christopher Sleeper, Lynn A. Hoskoppal, Arvind Silversides, Candice Radhakrishnan, Rupa Markham, Larry Rhodes, John F. Dugan, Lauryn M. Brown, Nicole Ermis, Peter Fuller, Stephanie Cotts, Timothy Brett Rodriguez, Fred Henry Lindsay, Ian Beers, Sue Aizenstein, Howard Bellinger, David C. Newburger, Jane W. Umfleet, Laura Glass Cohen, Scott Zaidi, Ali Gurvitz, Michelle J Cardiovasc Dev Dis Technical Note Dramatic advances in the management of congenital heart disease (CHD) have improved survival to adulthood from less than 10% in the 1960s to over 90% in the current era, such that adult CHD (ACHD) patients now outnumber their pediatric counterparts. ACHD patients demonstrate domain-specific neurocognitive deficits associated with reduced quality of life that include deficits in educational attainment and social interaction. Our hypothesis is that ACHD patients exhibit vascular brain injury and structural/physiological brain alterations that are predictive of specific neurocognitive deficits modified by behavioral and environmental enrichment proxies of cognitive reserve (e.g., level of education and lifestyle/social habits). This technical note describes an ancillary study to the National Heart, Lung, and Blood Institute (NHLBI)-funded Pediatric Heart Network (PHN) “Multi-Institutional Neurocognitive Discovery Study (MINDS) in Adult Congenital Heart Disease (ACHD)”. Leveraging clinical, neuropsychological, and biospecimen data from the parent study, our study will provide structural–physiological correlates of neurocognitive outcomes, representing the first multi-center neuroimaging initiative to be performed in ACHD patients. Limitations of the study include recruitment challenges inherent to an ancillary study, implantable cardiac devices, and harmonization of neuroimaging biomarkers. Results from this research will help shape the care of ACHD patients and further our understanding of the interplay between brain injury and cognitive reserve. MDPI 2023-09-06 /pmc/articles/PMC10532244/ /pubmed/37754810 http://dx.doi.org/10.3390/jcdd10090381 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Technical Note Panigrahy, Ashok Schmithorst, Vanessa Ceschin, Rafael Lee, Vince Beluk, Nancy Wallace, Julia Wheaton, Olivia Chenevert, Thomas Qiu, Deqiang Lee, James N Nencka, Andrew Gagoski, Borjan Berman, Jeffrey I. Yuan, Weihong Macgowan, Christopher Coatsworth, James Fleysher, Lazar Cannistraci, Christopher Sleeper, Lynn A. Hoskoppal, Arvind Silversides, Candice Radhakrishnan, Rupa Markham, Larry Rhodes, John F. Dugan, Lauryn M. Brown, Nicole Ermis, Peter Fuller, Stephanie Cotts, Timothy Brett Rodriguez, Fred Henry Lindsay, Ian Beers, Sue Aizenstein, Howard Bellinger, David C. Newburger, Jane W. Umfleet, Laura Glass Cohen, Scott Zaidi, Ali Gurvitz, Michelle Design and Harmonization Approach for the Multi-Institutional Neurocognitive Discovery Study (MINDS) of Adult Congenital Heart Disease (ACHD) Neuroimaging Ancillary Study: A Technical Note |
title | Design and Harmonization Approach for the Multi-Institutional Neurocognitive Discovery Study (MINDS) of Adult Congenital Heart Disease (ACHD) Neuroimaging Ancillary Study: A Technical Note |
title_full | Design and Harmonization Approach for the Multi-Institutional Neurocognitive Discovery Study (MINDS) of Adult Congenital Heart Disease (ACHD) Neuroimaging Ancillary Study: A Technical Note |
title_fullStr | Design and Harmonization Approach for the Multi-Institutional Neurocognitive Discovery Study (MINDS) of Adult Congenital Heart Disease (ACHD) Neuroimaging Ancillary Study: A Technical Note |
title_full_unstemmed | Design and Harmonization Approach for the Multi-Institutional Neurocognitive Discovery Study (MINDS) of Adult Congenital Heart Disease (ACHD) Neuroimaging Ancillary Study: A Technical Note |
title_short | Design and Harmonization Approach for the Multi-Institutional Neurocognitive Discovery Study (MINDS) of Adult Congenital Heart Disease (ACHD) Neuroimaging Ancillary Study: A Technical Note |
title_sort | design and harmonization approach for the multi-institutional neurocognitive discovery study (minds) of adult congenital heart disease (achd) neuroimaging ancillary study: a technical note |
topic | Technical Note |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532244/ https://www.ncbi.nlm.nih.gov/pubmed/37754810 http://dx.doi.org/10.3390/jcdd10090381 |
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