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Impact of Impaired Kidney Function on Arrhythmia-Promoting Cardiac Ion Channel Regulation

Chronic kidney disease (CKD) is associated with a significantly increased risk of cardiovascular events and sudden cardiac death. Although arrhythmias are one of the most common causes of sudden cardiac death in CKD patients, the molecular mechanisms involved in the development of arrhythmias are st...

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Autores principales: Sinha, Frederick, Schweda, Frank, Maier, Lars S., Wagner, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532292/
https://www.ncbi.nlm.nih.gov/pubmed/37762501
http://dx.doi.org/10.3390/ijms241814198
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author Sinha, Frederick
Schweda, Frank
Maier, Lars S.
Wagner, Stefan
author_facet Sinha, Frederick
Schweda, Frank
Maier, Lars S.
Wagner, Stefan
author_sort Sinha, Frederick
collection PubMed
description Chronic kidney disease (CKD) is associated with a significantly increased risk of cardiovascular events and sudden cardiac death. Although arrhythmias are one of the most common causes of sudden cardiac death in CKD patients, the molecular mechanisms involved in the development of arrhythmias are still poorly understood. In this narrative review, therefore, we summarize the current knowledge on the regulation of cardiac ion channels that contribute to arrhythmia in CKD. We do this by first explaining the excitation–contraction coupling, outlining current translational research approaches, then explaining the main characteristics in CKD patients, such as abnormalities in electrolytes and pH, activation of the autonomic nervous system, and the renin–angiotensin–aldosterone system, as well as current evidence for proarrhythmic properties of uremic toxins. Finally, we discuss the substance class of sodium–glucose co-transporter 2 inhibitors (SGLT2i) on their potential to modify cardiac channel regulation in CKD and, therefore, as a treatment option for arrhythmias.
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spelling pubmed-105322922023-09-28 Impact of Impaired Kidney Function on Arrhythmia-Promoting Cardiac Ion Channel Regulation Sinha, Frederick Schweda, Frank Maier, Lars S. Wagner, Stefan Int J Mol Sci Review Chronic kidney disease (CKD) is associated with a significantly increased risk of cardiovascular events and sudden cardiac death. Although arrhythmias are one of the most common causes of sudden cardiac death in CKD patients, the molecular mechanisms involved in the development of arrhythmias are still poorly understood. In this narrative review, therefore, we summarize the current knowledge on the regulation of cardiac ion channels that contribute to arrhythmia in CKD. We do this by first explaining the excitation–contraction coupling, outlining current translational research approaches, then explaining the main characteristics in CKD patients, such as abnormalities in electrolytes and pH, activation of the autonomic nervous system, and the renin–angiotensin–aldosterone system, as well as current evidence for proarrhythmic properties of uremic toxins. Finally, we discuss the substance class of sodium–glucose co-transporter 2 inhibitors (SGLT2i) on their potential to modify cardiac channel regulation in CKD and, therefore, as a treatment option for arrhythmias. MDPI 2023-09-17 /pmc/articles/PMC10532292/ /pubmed/37762501 http://dx.doi.org/10.3390/ijms241814198 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sinha, Frederick
Schweda, Frank
Maier, Lars S.
Wagner, Stefan
Impact of Impaired Kidney Function on Arrhythmia-Promoting Cardiac Ion Channel Regulation
title Impact of Impaired Kidney Function on Arrhythmia-Promoting Cardiac Ion Channel Regulation
title_full Impact of Impaired Kidney Function on Arrhythmia-Promoting Cardiac Ion Channel Regulation
title_fullStr Impact of Impaired Kidney Function on Arrhythmia-Promoting Cardiac Ion Channel Regulation
title_full_unstemmed Impact of Impaired Kidney Function on Arrhythmia-Promoting Cardiac Ion Channel Regulation
title_short Impact of Impaired Kidney Function on Arrhythmia-Promoting Cardiac Ion Channel Regulation
title_sort impact of impaired kidney function on arrhythmia-promoting cardiac ion channel regulation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532292/
https://www.ncbi.nlm.nih.gov/pubmed/37762501
http://dx.doi.org/10.3390/ijms241814198
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