Cargando…
Impact of Impaired Kidney Function on Arrhythmia-Promoting Cardiac Ion Channel Regulation
Chronic kidney disease (CKD) is associated with a significantly increased risk of cardiovascular events and sudden cardiac death. Although arrhythmias are one of the most common causes of sudden cardiac death in CKD patients, the molecular mechanisms involved in the development of arrhythmias are st...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532292/ https://www.ncbi.nlm.nih.gov/pubmed/37762501 http://dx.doi.org/10.3390/ijms241814198 |
_version_ | 1785111924213547008 |
---|---|
author | Sinha, Frederick Schweda, Frank Maier, Lars S. Wagner, Stefan |
author_facet | Sinha, Frederick Schweda, Frank Maier, Lars S. Wagner, Stefan |
author_sort | Sinha, Frederick |
collection | PubMed |
description | Chronic kidney disease (CKD) is associated with a significantly increased risk of cardiovascular events and sudden cardiac death. Although arrhythmias are one of the most common causes of sudden cardiac death in CKD patients, the molecular mechanisms involved in the development of arrhythmias are still poorly understood. In this narrative review, therefore, we summarize the current knowledge on the regulation of cardiac ion channels that contribute to arrhythmia in CKD. We do this by first explaining the excitation–contraction coupling, outlining current translational research approaches, then explaining the main characteristics in CKD patients, such as abnormalities in electrolytes and pH, activation of the autonomic nervous system, and the renin–angiotensin–aldosterone system, as well as current evidence for proarrhythmic properties of uremic toxins. Finally, we discuss the substance class of sodium–glucose co-transporter 2 inhibitors (SGLT2i) on their potential to modify cardiac channel regulation in CKD and, therefore, as a treatment option for arrhythmias. |
format | Online Article Text |
id | pubmed-10532292 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105322922023-09-28 Impact of Impaired Kidney Function on Arrhythmia-Promoting Cardiac Ion Channel Regulation Sinha, Frederick Schweda, Frank Maier, Lars S. Wagner, Stefan Int J Mol Sci Review Chronic kidney disease (CKD) is associated with a significantly increased risk of cardiovascular events and sudden cardiac death. Although arrhythmias are one of the most common causes of sudden cardiac death in CKD patients, the molecular mechanisms involved in the development of arrhythmias are still poorly understood. In this narrative review, therefore, we summarize the current knowledge on the regulation of cardiac ion channels that contribute to arrhythmia in CKD. We do this by first explaining the excitation–contraction coupling, outlining current translational research approaches, then explaining the main characteristics in CKD patients, such as abnormalities in electrolytes and pH, activation of the autonomic nervous system, and the renin–angiotensin–aldosterone system, as well as current evidence for proarrhythmic properties of uremic toxins. Finally, we discuss the substance class of sodium–glucose co-transporter 2 inhibitors (SGLT2i) on their potential to modify cardiac channel regulation in CKD and, therefore, as a treatment option for arrhythmias. MDPI 2023-09-17 /pmc/articles/PMC10532292/ /pubmed/37762501 http://dx.doi.org/10.3390/ijms241814198 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sinha, Frederick Schweda, Frank Maier, Lars S. Wagner, Stefan Impact of Impaired Kidney Function on Arrhythmia-Promoting Cardiac Ion Channel Regulation |
title | Impact of Impaired Kidney Function on Arrhythmia-Promoting Cardiac Ion Channel Regulation |
title_full | Impact of Impaired Kidney Function on Arrhythmia-Promoting Cardiac Ion Channel Regulation |
title_fullStr | Impact of Impaired Kidney Function on Arrhythmia-Promoting Cardiac Ion Channel Regulation |
title_full_unstemmed | Impact of Impaired Kidney Function on Arrhythmia-Promoting Cardiac Ion Channel Regulation |
title_short | Impact of Impaired Kidney Function on Arrhythmia-Promoting Cardiac Ion Channel Regulation |
title_sort | impact of impaired kidney function on arrhythmia-promoting cardiac ion channel regulation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532292/ https://www.ncbi.nlm.nih.gov/pubmed/37762501 http://dx.doi.org/10.3390/ijms241814198 |
work_keys_str_mv | AT sinhafrederick impactofimpairedkidneyfunctiononarrhythmiapromotingcardiacionchannelregulation AT schwedafrank impactofimpairedkidneyfunctiononarrhythmiapromotingcardiacionchannelregulation AT maierlarss impactofimpairedkidneyfunctiononarrhythmiapromotingcardiacionchannelregulation AT wagnerstefan impactofimpairedkidneyfunctiononarrhythmiapromotingcardiacionchannelregulation |