Cargando…

Role of Serum Interleukin-6, Interleukin-1β and Interleukin-10 in Assessment of Disease Activity and Nutritional Status in Patients with Inflammatory Bowel Disease

Inflammatory bowel diseases (IBD) are characterised by multifactorial and chronic inflammation. Much attention has been paid to immune dysfunction in inflammatory bowel diseases. The aim of this study was to assess the usefulness of serum IL-6, IL-1β and IL-10 in determining the activity and nutriti...

Descripción completa

Detalles Bibliográficos
Autores principales: Godala, Małgorzata, Gaszyńska, Ewelina, Walczak, Konrad, Małecka-Wojciesko, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532332/
https://www.ncbi.nlm.nih.gov/pubmed/37762896
http://dx.doi.org/10.3390/jcm12185956
_version_ 1785111935072600064
author Godala, Małgorzata
Gaszyńska, Ewelina
Walczak, Konrad
Małecka-Wojciesko, Ewa
author_facet Godala, Małgorzata
Gaszyńska, Ewelina
Walczak, Konrad
Małecka-Wojciesko, Ewa
author_sort Godala, Małgorzata
collection PubMed
description Inflammatory bowel diseases (IBD) are characterised by multifactorial and chronic inflammation. Much attention has been paid to immune dysfunction in inflammatory bowel diseases. The aim of this study was to assess the usefulness of serum IL-6, IL-1β and IL-10 in determining the activity and nutritional status in IBD patients. The case–control study was carried out on 82 patients with IBD; the control group consisted of 25 clinically healthy subjects. The serum concentrations of IL-6, IL-1 β and IL-10 were determined by the quantitative sandwich enzyme-linked immunosorbent assay. There were no significant differences in IL-6 and IL-1β levels in UC and CD patients according to disease activity as assessed by the Montreal classification, Partial Mayo Score and CDAI. Significantly higher IL-6 levels were found in patients with low body fat in comparison to patients with normal body fat. Furthermore, significantly higher mean IL-6 levels were observed in patients with excess body fat in comparison to patients with normal body fat, and also in comparison to patients with deficient body fat. IL-6 and IL-1β may provide extra information regarding the nutritional status of IBD patients. IL-10 can be considered a non-invasive biomarker of IBD activity.
format Online
Article
Text
id pubmed-10532332
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-105323322023-09-28 Role of Serum Interleukin-6, Interleukin-1β and Interleukin-10 in Assessment of Disease Activity and Nutritional Status in Patients with Inflammatory Bowel Disease Godala, Małgorzata Gaszyńska, Ewelina Walczak, Konrad Małecka-Wojciesko, Ewa J Clin Med Article Inflammatory bowel diseases (IBD) are characterised by multifactorial and chronic inflammation. Much attention has been paid to immune dysfunction in inflammatory bowel diseases. The aim of this study was to assess the usefulness of serum IL-6, IL-1β and IL-10 in determining the activity and nutritional status in IBD patients. The case–control study was carried out on 82 patients with IBD; the control group consisted of 25 clinically healthy subjects. The serum concentrations of IL-6, IL-1 β and IL-10 were determined by the quantitative sandwich enzyme-linked immunosorbent assay. There were no significant differences in IL-6 and IL-1β levels in UC and CD patients according to disease activity as assessed by the Montreal classification, Partial Mayo Score and CDAI. Significantly higher IL-6 levels were found in patients with low body fat in comparison to patients with normal body fat. Furthermore, significantly higher mean IL-6 levels were observed in patients with excess body fat in comparison to patients with normal body fat, and also in comparison to patients with deficient body fat. IL-6 and IL-1β may provide extra information regarding the nutritional status of IBD patients. IL-10 can be considered a non-invasive biomarker of IBD activity. MDPI 2023-09-13 /pmc/articles/PMC10532332/ /pubmed/37762896 http://dx.doi.org/10.3390/jcm12185956 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Godala, Małgorzata
Gaszyńska, Ewelina
Walczak, Konrad
Małecka-Wojciesko, Ewa
Role of Serum Interleukin-6, Interleukin-1β and Interleukin-10 in Assessment of Disease Activity and Nutritional Status in Patients with Inflammatory Bowel Disease
title Role of Serum Interleukin-6, Interleukin-1β and Interleukin-10 in Assessment of Disease Activity and Nutritional Status in Patients with Inflammatory Bowel Disease
title_full Role of Serum Interleukin-6, Interleukin-1β and Interleukin-10 in Assessment of Disease Activity and Nutritional Status in Patients with Inflammatory Bowel Disease
title_fullStr Role of Serum Interleukin-6, Interleukin-1β and Interleukin-10 in Assessment of Disease Activity and Nutritional Status in Patients with Inflammatory Bowel Disease
title_full_unstemmed Role of Serum Interleukin-6, Interleukin-1β and Interleukin-10 in Assessment of Disease Activity and Nutritional Status in Patients with Inflammatory Bowel Disease
title_short Role of Serum Interleukin-6, Interleukin-1β and Interleukin-10 in Assessment of Disease Activity and Nutritional Status in Patients with Inflammatory Bowel Disease
title_sort role of serum interleukin-6, interleukin-1β and interleukin-10 in assessment of disease activity and nutritional status in patients with inflammatory bowel disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532332/
https://www.ncbi.nlm.nih.gov/pubmed/37762896
http://dx.doi.org/10.3390/jcm12185956
work_keys_str_mv AT godalamałgorzata roleofseruminterleukin6interleukin1bandinterleukin10inassessmentofdiseaseactivityandnutritionalstatusinpatientswithinflammatoryboweldisease
AT gaszynskaewelina roleofseruminterleukin6interleukin1bandinterleukin10inassessmentofdiseaseactivityandnutritionalstatusinpatientswithinflammatoryboweldisease
AT walczakkonrad roleofseruminterleukin6interleukin1bandinterleukin10inassessmentofdiseaseactivityandnutritionalstatusinpatientswithinflammatoryboweldisease
AT małeckawojcieskoewa roleofseruminterleukin6interleukin1bandinterleukin10inassessmentofdiseaseactivityandnutritionalstatusinpatientswithinflammatoryboweldisease