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The Influence of SARS-CoV-2 Infection on Acute Myocardial Infarction Outcomes

Background: This multicenter retrospective study with a control group was designed to assess the influence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on the outcomes of patients with myocardial infarction (MI). Methods: A total of 129 patients with COVID-19 who were tr...

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Autores principales: Hrycek, Eugeniusz, Walawska-Hrycek, Anna, Hamankiewicz, Maciej, Milewski, Krzysztof, Nowakowski, Przemysław, Buszman, Piotr, Żurakowski, Aleksander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532337/
https://www.ncbi.nlm.nih.gov/pubmed/37762840
http://dx.doi.org/10.3390/jcm12185899
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author Hrycek, Eugeniusz
Walawska-Hrycek, Anna
Hamankiewicz, Maciej
Milewski, Krzysztof
Nowakowski, Przemysław
Buszman, Piotr
Żurakowski, Aleksander
author_facet Hrycek, Eugeniusz
Walawska-Hrycek, Anna
Hamankiewicz, Maciej
Milewski, Krzysztof
Nowakowski, Przemysław
Buszman, Piotr
Żurakowski, Aleksander
author_sort Hrycek, Eugeniusz
collection PubMed
description Background: This multicenter retrospective study with a control group was designed to assess the influence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on the outcomes of patients with myocardial infarction (MI). Methods: A total of 129 patients with COVID-19 who were treated for MI were included in this study. The control group comprised 129 comparable patients without SARS-CoV-2 infection. The in-hospital, out-of-hospital, and overall mortality were analyzed. Results: A total of thirty-one (24%) patients died in the study group, and two (1.6%) patients died in the control group (OR = 20.09; CI: 4.69–85.97; p < 0.001). Similar results were observed in all analyzed patient subgroups. Multivariable Cox regression analysis confirmed the significant influence of SARS-CoV-2 infection on in-hospital outcomes (HR: 8.48459; CI: 1.982–36.320; p = 0.004). Subanalysis of the groups with COVID-19 plus ST-elevation MI (STEMI) or non-ST-elevation MI (NSTEMI) revealed comparable mortality rates: 14 (21.12%) patients in the NSTEMI group and 17 (26.98%) patients in the STEMI subgroup died (OR: 1.3; CI: 0.56–3.37; p = 0.45). During out-of-hospital observation, no differences in mortality were observed (OR: 0.77; CI: 0.11–4.07; p = 0.73). Conclusions: SARS-CoV-2 infection affects the in-hospital outcomes of patients with both MI and COVID-19, regardless of MI type (STEMI vs. NSTEMI).
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spelling pubmed-105323372023-09-28 The Influence of SARS-CoV-2 Infection on Acute Myocardial Infarction Outcomes Hrycek, Eugeniusz Walawska-Hrycek, Anna Hamankiewicz, Maciej Milewski, Krzysztof Nowakowski, Przemysław Buszman, Piotr Żurakowski, Aleksander J Clin Med Article Background: This multicenter retrospective study with a control group was designed to assess the influence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on the outcomes of patients with myocardial infarction (MI). Methods: A total of 129 patients with COVID-19 who were treated for MI were included in this study. The control group comprised 129 comparable patients without SARS-CoV-2 infection. The in-hospital, out-of-hospital, and overall mortality were analyzed. Results: A total of thirty-one (24%) patients died in the study group, and two (1.6%) patients died in the control group (OR = 20.09; CI: 4.69–85.97; p < 0.001). Similar results were observed in all analyzed patient subgroups. Multivariable Cox regression analysis confirmed the significant influence of SARS-CoV-2 infection on in-hospital outcomes (HR: 8.48459; CI: 1.982–36.320; p = 0.004). Subanalysis of the groups with COVID-19 plus ST-elevation MI (STEMI) or non-ST-elevation MI (NSTEMI) revealed comparable mortality rates: 14 (21.12%) patients in the NSTEMI group and 17 (26.98%) patients in the STEMI subgroup died (OR: 1.3; CI: 0.56–3.37; p = 0.45). During out-of-hospital observation, no differences in mortality were observed (OR: 0.77; CI: 0.11–4.07; p = 0.73). Conclusions: SARS-CoV-2 infection affects the in-hospital outcomes of patients with both MI and COVID-19, regardless of MI type (STEMI vs. NSTEMI). MDPI 2023-09-11 /pmc/articles/PMC10532337/ /pubmed/37762840 http://dx.doi.org/10.3390/jcm12185899 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hrycek, Eugeniusz
Walawska-Hrycek, Anna
Hamankiewicz, Maciej
Milewski, Krzysztof
Nowakowski, Przemysław
Buszman, Piotr
Żurakowski, Aleksander
The Influence of SARS-CoV-2 Infection on Acute Myocardial Infarction Outcomes
title The Influence of SARS-CoV-2 Infection on Acute Myocardial Infarction Outcomes
title_full The Influence of SARS-CoV-2 Infection on Acute Myocardial Infarction Outcomes
title_fullStr The Influence of SARS-CoV-2 Infection on Acute Myocardial Infarction Outcomes
title_full_unstemmed The Influence of SARS-CoV-2 Infection on Acute Myocardial Infarction Outcomes
title_short The Influence of SARS-CoV-2 Infection on Acute Myocardial Infarction Outcomes
title_sort influence of sars-cov-2 infection on acute myocardial infarction outcomes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532337/
https://www.ncbi.nlm.nih.gov/pubmed/37762840
http://dx.doi.org/10.3390/jcm12185899
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