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Revolutionizing Cancer Research: The Impact of Artificial Intelligence in Digital Biobanking
Background. Biobanks are vital research infrastructures aiming to collect, process, store, and distribute biological specimens along with associated data in an organized and governed manner. Exploiting diverse datasets produced by the biobanks and the downstream research from various sources and int...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532470/ https://www.ncbi.nlm.nih.gov/pubmed/37763157 http://dx.doi.org/10.3390/jpm13091390 |
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author | Frascarelli, Chiara Bonizzi, Giuseppina Musico, Camilla Rosella Mane, Eltjona Cassi, Cristina Guerini Rocco, Elena Farina, Annarosa Scarpa, Aldo Lawlor, Rita Reggiani Bonetti, Luca Caramaschi, Stefania Eccher, Albino Marletta, Stefano Fusco, Nicola |
author_facet | Frascarelli, Chiara Bonizzi, Giuseppina Musico, Camilla Rosella Mane, Eltjona Cassi, Cristina Guerini Rocco, Elena Farina, Annarosa Scarpa, Aldo Lawlor, Rita Reggiani Bonetti, Luca Caramaschi, Stefania Eccher, Albino Marletta, Stefano Fusco, Nicola |
author_sort | Frascarelli, Chiara |
collection | PubMed |
description | Background. Biobanks are vital research infrastructures aiming to collect, process, store, and distribute biological specimens along with associated data in an organized and governed manner. Exploiting diverse datasets produced by the biobanks and the downstream research from various sources and integrating bioinformatics and “omics” data has proven instrumental in advancing research such as cancer research. Biobanks offer different types of biological samples matched with rich datasets comprising clinicopathologic information. As digital pathology and artificial intelligence (AI) have entered the precision medicine arena, biobanks are progressively transitioning from mere biorepositories to integrated computational databanks. Consequently, the application of AI and machine learning on these biobank datasets holds huge potential to profoundly impact cancer research. Methods. In this paper, we explore how AI and machine learning can respond to the digital evolution of biobanks with flexibility, solutions, and effective services. We look at the different data that ranges from specimen-related data, including digital images, patient health records and downstream genetic/genomic data and resulting “Big Data” and the analytic approaches used for analysis. Results. These cutting-edge technologies can address the challenges faced by translational and clinical research, enhancing their capabilities in data management, analysis, and interpretation. By leveraging AI, biobanks can unlock valuable insights from their vast repositories, enabling the identification of novel biomarkers, prediction of treatment responses, and ultimately facilitating the development of personalized cancer therapies. Conclusions. The integration of biobanking with AI has the potential not only to expand the current understanding of cancer biology but also to pave the way for more precise, patient-centric healthcare strategies. |
format | Online Article Text |
id | pubmed-10532470 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105324702023-09-28 Revolutionizing Cancer Research: The Impact of Artificial Intelligence in Digital Biobanking Frascarelli, Chiara Bonizzi, Giuseppina Musico, Camilla Rosella Mane, Eltjona Cassi, Cristina Guerini Rocco, Elena Farina, Annarosa Scarpa, Aldo Lawlor, Rita Reggiani Bonetti, Luca Caramaschi, Stefania Eccher, Albino Marletta, Stefano Fusco, Nicola J Pers Med Review Background. Biobanks are vital research infrastructures aiming to collect, process, store, and distribute biological specimens along with associated data in an organized and governed manner. Exploiting diverse datasets produced by the biobanks and the downstream research from various sources and integrating bioinformatics and “omics” data has proven instrumental in advancing research such as cancer research. Biobanks offer different types of biological samples matched with rich datasets comprising clinicopathologic information. As digital pathology and artificial intelligence (AI) have entered the precision medicine arena, biobanks are progressively transitioning from mere biorepositories to integrated computational databanks. Consequently, the application of AI and machine learning on these biobank datasets holds huge potential to profoundly impact cancer research. Methods. In this paper, we explore how AI and machine learning can respond to the digital evolution of biobanks with flexibility, solutions, and effective services. We look at the different data that ranges from specimen-related data, including digital images, patient health records and downstream genetic/genomic data and resulting “Big Data” and the analytic approaches used for analysis. Results. These cutting-edge technologies can address the challenges faced by translational and clinical research, enhancing their capabilities in data management, analysis, and interpretation. By leveraging AI, biobanks can unlock valuable insights from their vast repositories, enabling the identification of novel biomarkers, prediction of treatment responses, and ultimately facilitating the development of personalized cancer therapies. Conclusions. The integration of biobanking with AI has the potential not only to expand the current understanding of cancer biology but also to pave the way for more precise, patient-centric healthcare strategies. MDPI 2023-09-16 /pmc/articles/PMC10532470/ /pubmed/37763157 http://dx.doi.org/10.3390/jpm13091390 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Frascarelli, Chiara Bonizzi, Giuseppina Musico, Camilla Rosella Mane, Eltjona Cassi, Cristina Guerini Rocco, Elena Farina, Annarosa Scarpa, Aldo Lawlor, Rita Reggiani Bonetti, Luca Caramaschi, Stefania Eccher, Albino Marletta, Stefano Fusco, Nicola Revolutionizing Cancer Research: The Impact of Artificial Intelligence in Digital Biobanking |
title | Revolutionizing Cancer Research: The Impact of Artificial Intelligence in Digital Biobanking |
title_full | Revolutionizing Cancer Research: The Impact of Artificial Intelligence in Digital Biobanking |
title_fullStr | Revolutionizing Cancer Research: The Impact of Artificial Intelligence in Digital Biobanking |
title_full_unstemmed | Revolutionizing Cancer Research: The Impact of Artificial Intelligence in Digital Biobanking |
title_short | Revolutionizing Cancer Research: The Impact of Artificial Intelligence in Digital Biobanking |
title_sort | revolutionizing cancer research: the impact of artificial intelligence in digital biobanking |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532470/ https://www.ncbi.nlm.nih.gov/pubmed/37763157 http://dx.doi.org/10.3390/jpm13091390 |
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