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Serum Levels of S100B Protein and Myelin Basic Protein as a Potential Biomarkers of Recurrent Depressive Disorders

Nowadays, nervous tissue damage proteins in serum are considered promising drug targets and biomarkers of Mood Disorders. In a cross-sectional naturalistic study, the S100B, MBP and GFAP levels in the blood serum were compared between two diagnostic groups (patients with Depressive Episode (DE, n =...

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Autores principales: Levchuk, Lyudmila A., Roschina, Olga V., Mikhalitskaya, Ekaterina V., Epimakhova, Elena V., Simutkin, German G., Bokhan, Nikolay A., Ivanova, Svetlana A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532562/
https://www.ncbi.nlm.nih.gov/pubmed/37763190
http://dx.doi.org/10.3390/jpm13091423
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author Levchuk, Lyudmila A.
Roschina, Olga V.
Mikhalitskaya, Ekaterina V.
Epimakhova, Elena V.
Simutkin, German G.
Bokhan, Nikolay A.
Ivanova, Svetlana A.
author_facet Levchuk, Lyudmila A.
Roschina, Olga V.
Mikhalitskaya, Ekaterina V.
Epimakhova, Elena V.
Simutkin, German G.
Bokhan, Nikolay A.
Ivanova, Svetlana A.
author_sort Levchuk, Lyudmila A.
collection PubMed
description Nowadays, nervous tissue damage proteins in serum are considered promising drug targets and biomarkers of Mood Disorders. In a cross-sectional naturalistic study, the S100B, MBP and GFAP levels in the blood serum were compared between two diagnostic groups (patients with Depressive Episode (DE, n = 28) and patients with Recurrent Depressive Disorder (RDD, n = 21)), and healthy controls (n = 25). The diagnostic value of serum markers was assessed by ROC analysis. In the DE group, we did not find changed levels of S100B, MBP and GFAP compared with controls. In the RDD group, we found decreased S100B level (p = 0.011) and increased MBP level (p = 0.015) in comparison to those in healthy controls. Provided ROC analysis indicates that MBP contributes to the development of a DE (AUC = 0.676; 95%Cl 0.525–0.826; p = 0.028), and S100B and MBP have a significant effect on the development of RDD (AUC = 0.732; 95%Cl 0.560–0.903; p = 0.013 and AUC = 0.712; 95%Cl 0.557–0.867; p = 0.015, correspondingly). The study of serum markers of nervous tissue damage in patients with a current DE indicates signs of disintegration of structural and functional relationships, dysfunction of gliotransmission, and impaired secretion of neurospecific proteins. Modified functions of astrocytes and oligodendrocytes are implicated in the pathophysiology of RDD.
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spelling pubmed-105325622023-09-28 Serum Levels of S100B Protein and Myelin Basic Protein as a Potential Biomarkers of Recurrent Depressive Disorders Levchuk, Lyudmila A. Roschina, Olga V. Mikhalitskaya, Ekaterina V. Epimakhova, Elena V. Simutkin, German G. Bokhan, Nikolay A. Ivanova, Svetlana A. J Pers Med Article Nowadays, nervous tissue damage proteins in serum are considered promising drug targets and biomarkers of Mood Disorders. In a cross-sectional naturalistic study, the S100B, MBP and GFAP levels in the blood serum were compared between two diagnostic groups (patients with Depressive Episode (DE, n = 28) and patients with Recurrent Depressive Disorder (RDD, n = 21)), and healthy controls (n = 25). The diagnostic value of serum markers was assessed by ROC analysis. In the DE group, we did not find changed levels of S100B, MBP and GFAP compared with controls. In the RDD group, we found decreased S100B level (p = 0.011) and increased MBP level (p = 0.015) in comparison to those in healthy controls. Provided ROC analysis indicates that MBP contributes to the development of a DE (AUC = 0.676; 95%Cl 0.525–0.826; p = 0.028), and S100B and MBP have a significant effect on the development of RDD (AUC = 0.732; 95%Cl 0.560–0.903; p = 0.013 and AUC = 0.712; 95%Cl 0.557–0.867; p = 0.015, correspondingly). The study of serum markers of nervous tissue damage in patients with a current DE indicates signs of disintegration of structural and functional relationships, dysfunction of gliotransmission, and impaired secretion of neurospecific proteins. Modified functions of astrocytes and oligodendrocytes are implicated in the pathophysiology of RDD. MDPI 2023-09-21 /pmc/articles/PMC10532562/ /pubmed/37763190 http://dx.doi.org/10.3390/jpm13091423 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Levchuk, Lyudmila A.
Roschina, Olga V.
Mikhalitskaya, Ekaterina V.
Epimakhova, Elena V.
Simutkin, German G.
Bokhan, Nikolay A.
Ivanova, Svetlana A.
Serum Levels of S100B Protein and Myelin Basic Protein as a Potential Biomarkers of Recurrent Depressive Disorders
title Serum Levels of S100B Protein and Myelin Basic Protein as a Potential Biomarkers of Recurrent Depressive Disorders
title_full Serum Levels of S100B Protein and Myelin Basic Protein as a Potential Biomarkers of Recurrent Depressive Disorders
title_fullStr Serum Levels of S100B Protein and Myelin Basic Protein as a Potential Biomarkers of Recurrent Depressive Disorders
title_full_unstemmed Serum Levels of S100B Protein and Myelin Basic Protein as a Potential Biomarkers of Recurrent Depressive Disorders
title_short Serum Levels of S100B Protein and Myelin Basic Protein as a Potential Biomarkers of Recurrent Depressive Disorders
title_sort serum levels of s100b protein and myelin basic protein as a potential biomarkers of recurrent depressive disorders
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532562/
https://www.ncbi.nlm.nih.gov/pubmed/37763190
http://dx.doi.org/10.3390/jpm13091423
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