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Head-to-Head Comparison of CZT-SPECT and SPECT/CT Myocardial Perfusion Imaging: Interobserver and Intraobserver Agreement and Diagnostic Performance

Background: Myocardial perfusion imaging (MPI) plays a crucial role in diagnosing coronary artery disease (CAD), with single-photon emission computed tomography (SPECT) being a widely accepted method. The accuracy of MPI relies on image quality and the expertise of physicians. While CZT-SPECT camera...

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Autores principales: Kalantari, Forough, Mohseninia, Nasibeh, Wetsch, Andreas, Harsini, Sara, Hehenwarter, Lukas, Schweighofer-Zwink, Gregor, Zamani-Siahkali, Nazanin, Rendl, Gundula, Beheshti, Mohsen, Pirich, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532584/
https://www.ncbi.nlm.nih.gov/pubmed/37763283
http://dx.doi.org/10.3390/life13091879
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author Kalantari, Forough
Mohseninia, Nasibeh
Wetsch, Andreas
Harsini, Sara
Hehenwarter, Lukas
Schweighofer-Zwink, Gregor
Zamani-Siahkali, Nazanin
Rendl, Gundula
Beheshti, Mohsen
Pirich, Christian
author_facet Kalantari, Forough
Mohseninia, Nasibeh
Wetsch, Andreas
Harsini, Sara
Hehenwarter, Lukas
Schweighofer-Zwink, Gregor
Zamani-Siahkali, Nazanin
Rendl, Gundula
Beheshti, Mohsen
Pirich, Christian
author_sort Kalantari, Forough
collection PubMed
description Background: Myocardial perfusion imaging (MPI) plays a crucial role in diagnosing coronary artery disease (CAD), with single-photon emission computed tomography (SPECT) being a widely accepted method. The accuracy of MPI relies on image quality and the expertise of physicians. While CZT-SPECT cameras offer advantages, they can be susceptible to attenuation artifacts. Therefore, our objective was to evaluate the diagnostic accuracy of CZT-SPECT and SPECT/CT in a clinical setting. Method: We conducted a prospective single-center study involving patients with known or suspected stable ischemic heart disease who underwent SPECT-MPI using CZT-SPECT and SPECT/CT scanners, and the latter was equipped with cardiofocal collimation. Experienced physicians performed analysis and reporting based on automated quantification and visual image interpretation. Results: A total of 77 patients (32 women (41.6%) and 45 men (58.4%) with an average age of 71.9 ± 8.9 years) were included. The agreement between readers regarding the final conclusion based on imaging reporting using both devices was very high (Kappa 0.87–0.93). Per-vessel analysis revealed a trend suggesting that CZT-SPECT was superior to conventional SPECT/CT in terms of sensitivity, positive predictive value (PPV), negative predictive value (NPV), and accuracy, although the difference did not reach statistical significance. Conclusion: Our study demonstrated that CZT-SPECT imaging offers comparable diagnostic accuracy, improved patient comfort, and eliminates CT-induced radiation compared to SPECT/CT. These findings suggest that cardiac CZT-SPECT imaging has the potential to become a valuable imaging modality in clinical practice.
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spelling pubmed-105325842023-09-28 Head-to-Head Comparison of CZT-SPECT and SPECT/CT Myocardial Perfusion Imaging: Interobserver and Intraobserver Agreement and Diagnostic Performance Kalantari, Forough Mohseninia, Nasibeh Wetsch, Andreas Harsini, Sara Hehenwarter, Lukas Schweighofer-Zwink, Gregor Zamani-Siahkali, Nazanin Rendl, Gundula Beheshti, Mohsen Pirich, Christian Life (Basel) Article Background: Myocardial perfusion imaging (MPI) plays a crucial role in diagnosing coronary artery disease (CAD), with single-photon emission computed tomography (SPECT) being a widely accepted method. The accuracy of MPI relies on image quality and the expertise of physicians. While CZT-SPECT cameras offer advantages, they can be susceptible to attenuation artifacts. Therefore, our objective was to evaluate the diagnostic accuracy of CZT-SPECT and SPECT/CT in a clinical setting. Method: We conducted a prospective single-center study involving patients with known or suspected stable ischemic heart disease who underwent SPECT-MPI using CZT-SPECT and SPECT/CT scanners, and the latter was equipped with cardiofocal collimation. Experienced physicians performed analysis and reporting based on automated quantification and visual image interpretation. Results: A total of 77 patients (32 women (41.6%) and 45 men (58.4%) with an average age of 71.9 ± 8.9 years) were included. The agreement between readers regarding the final conclusion based on imaging reporting using both devices was very high (Kappa 0.87–0.93). Per-vessel analysis revealed a trend suggesting that CZT-SPECT was superior to conventional SPECT/CT in terms of sensitivity, positive predictive value (PPV), negative predictive value (NPV), and accuracy, although the difference did not reach statistical significance. Conclusion: Our study demonstrated that CZT-SPECT imaging offers comparable diagnostic accuracy, improved patient comfort, and eliminates CT-induced radiation compared to SPECT/CT. These findings suggest that cardiac CZT-SPECT imaging has the potential to become a valuable imaging modality in clinical practice. MDPI 2023-09-07 /pmc/articles/PMC10532584/ /pubmed/37763283 http://dx.doi.org/10.3390/life13091879 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kalantari, Forough
Mohseninia, Nasibeh
Wetsch, Andreas
Harsini, Sara
Hehenwarter, Lukas
Schweighofer-Zwink, Gregor
Zamani-Siahkali, Nazanin
Rendl, Gundula
Beheshti, Mohsen
Pirich, Christian
Head-to-Head Comparison of CZT-SPECT and SPECT/CT Myocardial Perfusion Imaging: Interobserver and Intraobserver Agreement and Diagnostic Performance
title Head-to-Head Comparison of CZT-SPECT and SPECT/CT Myocardial Perfusion Imaging: Interobserver and Intraobserver Agreement and Diagnostic Performance
title_full Head-to-Head Comparison of CZT-SPECT and SPECT/CT Myocardial Perfusion Imaging: Interobserver and Intraobserver Agreement and Diagnostic Performance
title_fullStr Head-to-Head Comparison of CZT-SPECT and SPECT/CT Myocardial Perfusion Imaging: Interobserver and Intraobserver Agreement and Diagnostic Performance
title_full_unstemmed Head-to-Head Comparison of CZT-SPECT and SPECT/CT Myocardial Perfusion Imaging: Interobserver and Intraobserver Agreement and Diagnostic Performance
title_short Head-to-Head Comparison of CZT-SPECT and SPECT/CT Myocardial Perfusion Imaging: Interobserver and Intraobserver Agreement and Diagnostic Performance
title_sort head-to-head comparison of czt-spect and spect/ct myocardial perfusion imaging: interobserver and intraobserver agreement and diagnostic performance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532584/
https://www.ncbi.nlm.nih.gov/pubmed/37763283
http://dx.doi.org/10.3390/life13091879
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