An Investigation of Structure–Activity Relationships and Cell Death Mechanisms of the Marine Alkaloids Discorhabdins in Merkel Cell Carcinoma Cells

A library of naturally occurring and semi-synthetic discorhabdins was assessed for their effects on Merkel cell carcinoma (MCC) cell viability. The set included five new natural products and semi-synthetic compounds whose structures were elucidated with NMR, HRMS, and ECD techniques. Several discorh...

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Detalles Bibliográficos
Autores principales: Orfanoudaki, Maria, Smith, Emily A., Hill, Natasha T., Garman, Khalid A., Brownell, Isaac, Copp, Brent R., Grkovic, Tanja, Henrich, Curtis J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532587/
https://www.ncbi.nlm.nih.gov/pubmed/37755087
http://dx.doi.org/10.3390/md21090474

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