Viscosity Measurement of CO(2)–Solvent Mixtures for the Study of the Morphology and Size of Crystalline Particles Obtained Using Supercritical Antisolvent Precipitation

The viscosity values of CO(2)–dimethylphormamide, chloroform, methanol, isopropanol, ethyl acetate, acetone, and dimethyl sulfoxide mixtures were measured at a pressure of 150 bar and a temperature of 313 K. The correlation of the mean size of levofloxacin hydrochloride and malonic acid particles pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Vorobei, Anton M., Kostenko, Mikhail O., Parenago, Olga O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532671/
https://www.ncbi.nlm.nih.gov/pubmed/37763429
http://dx.doi.org/10.3390/ma16186151
_version_ 1785112015779397632
author Vorobei, Anton M.
Kostenko, Mikhail O.
Parenago, Olga O.
author_facet Vorobei, Anton M.
Kostenko, Mikhail O.
Parenago, Olga O.
author_sort Vorobei, Anton M.
collection PubMed
description The viscosity values of CO(2)–dimethylphormamide, chloroform, methanol, isopropanol, ethyl acetate, acetone, and dimethyl sulfoxide mixtures were measured at a pressure of 150 bar and a temperature of 313 K. The correlation of the mean size of levofloxacin hydrochloride and malonic acid particles precipitated using the SAS method with the viscosity of the used CO(2)–solvent mixtures is shown. The high viscosity of the mixtures leads to slower mixing of the solution and the antisolvent. Therefore, crystallization occurs at large fractions of the solvent, and as a consequence at a lower supersaturation. This causes the formation of larger particles when using more viscous solvents in SAS.
format Online
Article
Text
id pubmed-10532671
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-105326712023-09-28 Viscosity Measurement of CO(2)–Solvent Mixtures for the Study of the Morphology and Size of Crystalline Particles Obtained Using Supercritical Antisolvent Precipitation Vorobei, Anton M. Kostenko, Mikhail O. Parenago, Olga O. Materials (Basel) Article The viscosity values of CO(2)–dimethylphormamide, chloroform, methanol, isopropanol, ethyl acetate, acetone, and dimethyl sulfoxide mixtures were measured at a pressure of 150 bar and a temperature of 313 K. The correlation of the mean size of levofloxacin hydrochloride and malonic acid particles precipitated using the SAS method with the viscosity of the used CO(2)–solvent mixtures is shown. The high viscosity of the mixtures leads to slower mixing of the solution and the antisolvent. Therefore, crystallization occurs at large fractions of the solvent, and as a consequence at a lower supersaturation. This causes the formation of larger particles when using more viscous solvents in SAS. MDPI 2023-09-10 /pmc/articles/PMC10532671/ /pubmed/37763429 http://dx.doi.org/10.3390/ma16186151 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vorobei, Anton M.
Kostenko, Mikhail O.
Parenago, Olga O.
Viscosity Measurement of CO(2)–Solvent Mixtures for the Study of the Morphology and Size of Crystalline Particles Obtained Using Supercritical Antisolvent Precipitation
title Viscosity Measurement of CO(2)–Solvent Mixtures for the Study of the Morphology and Size of Crystalline Particles Obtained Using Supercritical Antisolvent Precipitation
title_full Viscosity Measurement of CO(2)–Solvent Mixtures for the Study of the Morphology and Size of Crystalline Particles Obtained Using Supercritical Antisolvent Precipitation
title_fullStr Viscosity Measurement of CO(2)–Solvent Mixtures for the Study of the Morphology and Size of Crystalline Particles Obtained Using Supercritical Antisolvent Precipitation
title_full_unstemmed Viscosity Measurement of CO(2)–Solvent Mixtures for the Study of the Morphology and Size of Crystalline Particles Obtained Using Supercritical Antisolvent Precipitation
title_short Viscosity Measurement of CO(2)–Solvent Mixtures for the Study of the Morphology and Size of Crystalline Particles Obtained Using Supercritical Antisolvent Precipitation
title_sort viscosity measurement of co(2)–solvent mixtures for the study of the morphology and size of crystalline particles obtained using supercritical antisolvent precipitation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532671/
https://www.ncbi.nlm.nih.gov/pubmed/37763429
http://dx.doi.org/10.3390/ma16186151
work_keys_str_mv AT vorobeiantonm viscositymeasurementofco2solventmixturesforthestudyofthemorphologyandsizeofcrystallineparticlesobtainedusingsupercriticalantisolventprecipitation
AT kostenkomikhailo viscositymeasurementofco2solventmixturesforthestudyofthemorphologyandsizeofcrystallineparticlesobtainedusingsupercriticalantisolventprecipitation
AT parenagoolgao viscositymeasurementofco2solventmixturesforthestudyofthemorphologyandsizeofcrystallineparticlesobtainedusingsupercriticalantisolventprecipitation

Ejemplares similares