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Hidradenitis Suppurativa: An Interdisciplinary Problem in Dermatology, Gynecology, and Surgery—Pathogenesis, Comorbidities, and Current Treatments

Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic inflammatory disease that manifests as painful nodules, abscesses, draining dermal tunnels, and scarring in intertriginous areas such as the axillae, groin, and breasts. The nature of the disease and its chronicity have a destru...

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Autores principales: Nowak-Liduk, Agnieszka, Kitala, Diana, Ochała-Gierek, Gabriela, Łabuś, Wojciech, Bergler-Czop, Beata, Pietrauszka, Kornelia, Niemiec, Paweł, Szyluk, Karol, Gierek, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532726/
https://www.ncbi.nlm.nih.gov/pubmed/37763299
http://dx.doi.org/10.3390/life13091895
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author Nowak-Liduk, Agnieszka
Kitala, Diana
Ochała-Gierek, Gabriela
Łabuś, Wojciech
Bergler-Czop, Beata
Pietrauszka, Kornelia
Niemiec, Paweł
Szyluk, Karol
Gierek, Marcin
author_facet Nowak-Liduk, Agnieszka
Kitala, Diana
Ochała-Gierek, Gabriela
Łabuś, Wojciech
Bergler-Czop, Beata
Pietrauszka, Kornelia
Niemiec, Paweł
Szyluk, Karol
Gierek, Marcin
author_sort Nowak-Liduk, Agnieszka
collection PubMed
description Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic inflammatory disease that manifests as painful nodules, abscesses, draining dermal tunnels, and scarring in intertriginous areas such as the axillae, groin, and breasts. The nature of the disease and its chronicity have a destructive impact on mental health and quality of life. HS has an estimated global prevalence of 0.00033–4.1% and it disproportionately affects females compared to males. HS involving the female anogenital regions is reported rarely in the gynecological literature, and it can often be mistaken for other vulvar diseases. The distinct phenotypes and HS rarity cause delayed diagnosis and the implementation of effective treatment. Acne inversa is associated with several comorbidities, including metabolic disease, diabetes mellitus, inflammatory bowel diseases, and spondyloarthropathies. Although HS etiology and pathogenesis remain unclear, studies have shown that lifestyle, immunological processes, genetics, and hormonal predispositions may promote follicular hyperkeratosis, dilatation, and rupture, leading to the development of chronic tissue inflammation. This article provides updated information on HS pathogenesis, comorbidities, and treatment methods. Furthermore, we share our experience in the surgical treatment of the disease, which often proves most effective, and highlight that an interdisciplinary management approach ensures optimal outcomes.
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spelling pubmed-105327262023-09-28 Hidradenitis Suppurativa: An Interdisciplinary Problem in Dermatology, Gynecology, and Surgery—Pathogenesis, Comorbidities, and Current Treatments Nowak-Liduk, Agnieszka Kitala, Diana Ochała-Gierek, Gabriela Łabuś, Wojciech Bergler-Czop, Beata Pietrauszka, Kornelia Niemiec, Paweł Szyluk, Karol Gierek, Marcin Life (Basel) Review Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic inflammatory disease that manifests as painful nodules, abscesses, draining dermal tunnels, and scarring in intertriginous areas such as the axillae, groin, and breasts. The nature of the disease and its chronicity have a destructive impact on mental health and quality of life. HS has an estimated global prevalence of 0.00033–4.1% and it disproportionately affects females compared to males. HS involving the female anogenital regions is reported rarely in the gynecological literature, and it can often be mistaken for other vulvar diseases. The distinct phenotypes and HS rarity cause delayed diagnosis and the implementation of effective treatment. Acne inversa is associated with several comorbidities, including metabolic disease, diabetes mellitus, inflammatory bowel diseases, and spondyloarthropathies. Although HS etiology and pathogenesis remain unclear, studies have shown that lifestyle, immunological processes, genetics, and hormonal predispositions may promote follicular hyperkeratosis, dilatation, and rupture, leading to the development of chronic tissue inflammation. This article provides updated information on HS pathogenesis, comorbidities, and treatment methods. Furthermore, we share our experience in the surgical treatment of the disease, which often proves most effective, and highlight that an interdisciplinary management approach ensures optimal outcomes. MDPI 2023-09-11 /pmc/articles/PMC10532726/ /pubmed/37763299 http://dx.doi.org/10.3390/life13091895 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nowak-Liduk, Agnieszka
Kitala, Diana
Ochała-Gierek, Gabriela
Łabuś, Wojciech
Bergler-Czop, Beata
Pietrauszka, Kornelia
Niemiec, Paweł
Szyluk, Karol
Gierek, Marcin
Hidradenitis Suppurativa: An Interdisciplinary Problem in Dermatology, Gynecology, and Surgery—Pathogenesis, Comorbidities, and Current Treatments
title Hidradenitis Suppurativa: An Interdisciplinary Problem in Dermatology, Gynecology, and Surgery—Pathogenesis, Comorbidities, and Current Treatments
title_full Hidradenitis Suppurativa: An Interdisciplinary Problem in Dermatology, Gynecology, and Surgery—Pathogenesis, Comorbidities, and Current Treatments
title_fullStr Hidradenitis Suppurativa: An Interdisciplinary Problem in Dermatology, Gynecology, and Surgery—Pathogenesis, Comorbidities, and Current Treatments
title_full_unstemmed Hidradenitis Suppurativa: An Interdisciplinary Problem in Dermatology, Gynecology, and Surgery—Pathogenesis, Comorbidities, and Current Treatments
title_short Hidradenitis Suppurativa: An Interdisciplinary Problem in Dermatology, Gynecology, and Surgery—Pathogenesis, Comorbidities, and Current Treatments
title_sort hidradenitis suppurativa: an interdisciplinary problem in dermatology, gynecology, and surgery—pathogenesis, comorbidities, and current treatments
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532726/
https://www.ncbi.nlm.nih.gov/pubmed/37763299
http://dx.doi.org/10.3390/life13091895
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