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Bisphosphonates and Dental Implants: A Systematic Review and Meta-Analysis

The purpose of the present systematic review was to investigate the influence of bisphosphonates (BPs) on the dental implant failure rate and marginal bone loss (MBL). An electronic search was undertaken in three databases, plus a manual search of journals. Meta-analyses were performed, besides a me...

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Autores principales: Sulaiman, Nabaa, Fadhul, Fadi, Chrcanovic, Bruno Ramos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532755/
https://www.ncbi.nlm.nih.gov/pubmed/37763356
http://dx.doi.org/10.3390/ma16186078
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author Sulaiman, Nabaa
Fadhul, Fadi
Chrcanovic, Bruno Ramos
author_facet Sulaiman, Nabaa
Fadhul, Fadi
Chrcanovic, Bruno Ramos
author_sort Sulaiman, Nabaa
collection PubMed
description The purpose of the present systematic review was to investigate the influence of bisphosphonates (BPs) on the dental implant failure rate and marginal bone loss (MBL). An electronic search was undertaken in three databases, plus a manual search of journals. Meta-analyses were performed, besides a meta-regression in order to verify how the log odds ratio (OR) was associated with follow-up time. The five- and ten-year estimated implant survivals were calculated. The review included 33 publications. Altogether, there were 1727 and 21,986 implants placed in patients taking and not taking BPs, respectively. A pairwise meta-analysis (26 studies) showed that implants in BP patients had a higher failure risk in comparison to non-BP patients (OR 1.653, p = 0.047). There was an estimated decrease of 0.004 in log OR for every additional month of follow-up, although it was not significant (p = 0.259). The global estimated implant survival in patients taking BPs after 5 and 10 years was 94.2% (95% CI, 94.0–94.4) and 90.1% (95% CI, 89.8–90.3), respectively. It was not possible to make any reliable analysis concerning MBL, as only two studies reported MBL results separated by groups. There is a 65.3% higher risk of implant failure in patients taking BPs in comparison to patients not taking this class of drugs.
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spelling pubmed-105327552023-09-28 Bisphosphonates and Dental Implants: A Systematic Review and Meta-Analysis Sulaiman, Nabaa Fadhul, Fadi Chrcanovic, Bruno Ramos Materials (Basel) Systematic Review The purpose of the present systematic review was to investigate the influence of bisphosphonates (BPs) on the dental implant failure rate and marginal bone loss (MBL). An electronic search was undertaken in three databases, plus a manual search of journals. Meta-analyses were performed, besides a meta-regression in order to verify how the log odds ratio (OR) was associated with follow-up time. The five- and ten-year estimated implant survivals were calculated. The review included 33 publications. Altogether, there were 1727 and 21,986 implants placed in patients taking and not taking BPs, respectively. A pairwise meta-analysis (26 studies) showed that implants in BP patients had a higher failure risk in comparison to non-BP patients (OR 1.653, p = 0.047). There was an estimated decrease of 0.004 in log OR for every additional month of follow-up, although it was not significant (p = 0.259). The global estimated implant survival in patients taking BPs after 5 and 10 years was 94.2% (95% CI, 94.0–94.4) and 90.1% (95% CI, 89.8–90.3), respectively. It was not possible to make any reliable analysis concerning MBL, as only two studies reported MBL results separated by groups. There is a 65.3% higher risk of implant failure in patients taking BPs in comparison to patients not taking this class of drugs. MDPI 2023-09-05 /pmc/articles/PMC10532755/ /pubmed/37763356 http://dx.doi.org/10.3390/ma16186078 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Sulaiman, Nabaa
Fadhul, Fadi
Chrcanovic, Bruno Ramos
Bisphosphonates and Dental Implants: A Systematic Review and Meta-Analysis
title Bisphosphonates and Dental Implants: A Systematic Review and Meta-Analysis
title_full Bisphosphonates and Dental Implants: A Systematic Review and Meta-Analysis
title_fullStr Bisphosphonates and Dental Implants: A Systematic Review and Meta-Analysis
title_full_unstemmed Bisphosphonates and Dental Implants: A Systematic Review and Meta-Analysis
title_short Bisphosphonates and Dental Implants: A Systematic Review and Meta-Analysis
title_sort bisphosphonates and dental implants: a systematic review and meta-analysis
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532755/
https://www.ncbi.nlm.nih.gov/pubmed/37763356
http://dx.doi.org/10.3390/ma16186078
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