Anti-Inflammatory and Anticancer Effects of Anticoagulant Therapy in Patients with Malignancy

Optimizing the anticoagulation therapy is of pivotal importance in patients with a malignant tumor, as venous thromboembolism (VTE) has become the second-leading cause of death in this population. Cancer can highly increase the risk of thrombosis and bleeding. Consequently, the management of cancer-...

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Autores principales: Russo, Vincenzo, Falco, Luigi, Tessitore, Viviana, Mauriello, Alfredo, Catapano, Dario, Napolitano, Nicola, Tariq, Moiz, Caturano, Alfredo, Ciccarelli, Giovanni, D’Andrea, Antonello, Giordano, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532829/
https://www.ncbi.nlm.nih.gov/pubmed/37763292
http://dx.doi.org/10.3390/life13091888
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author Russo, Vincenzo
Falco, Luigi
Tessitore, Viviana
Mauriello, Alfredo
Catapano, Dario
Napolitano, Nicola
Tariq, Moiz
Caturano, Alfredo
Ciccarelli, Giovanni
D’Andrea, Antonello
Giordano, Antonio
author_facet Russo, Vincenzo
Falco, Luigi
Tessitore, Viviana
Mauriello, Alfredo
Catapano, Dario
Napolitano, Nicola
Tariq, Moiz
Caturano, Alfredo
Ciccarelli, Giovanni
D’Andrea, Antonello
Giordano, Antonio
author_sort Russo, Vincenzo
collection PubMed
description Optimizing the anticoagulation therapy is of pivotal importance in patients with a malignant tumor, as venous thromboembolism (VTE) has become the second-leading cause of death in this population. Cancer can highly increase the risk of thrombosis and bleeding. Consequently, the management of cancer-associated VTE is complex. In recent years, translational research has intensified, and several studies have highlighted the role of inflammatory cytokines in cancer growth and progression. Simultaneously, the pleiotropic effects of anticoagulants currently recommended for VTE have emerged. In this review, we describe the anti-inflammatory and anticancer effects of both direct oral anticoagulants (DOACs) and low-molecular-weight heparins (LWMHs).
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spelling pubmed-105328292023-09-28 Anti-Inflammatory and Anticancer Effects of Anticoagulant Therapy in Patients with Malignancy Russo, Vincenzo Falco, Luigi Tessitore, Viviana Mauriello, Alfredo Catapano, Dario Napolitano, Nicola Tariq, Moiz Caturano, Alfredo Ciccarelli, Giovanni D’Andrea, Antonello Giordano, Antonio Life (Basel) Review Optimizing the anticoagulation therapy is of pivotal importance in patients with a malignant tumor, as venous thromboembolism (VTE) has become the second-leading cause of death in this population. Cancer can highly increase the risk of thrombosis and bleeding. Consequently, the management of cancer-associated VTE is complex. In recent years, translational research has intensified, and several studies have highlighted the role of inflammatory cytokines in cancer growth and progression. Simultaneously, the pleiotropic effects of anticoagulants currently recommended for VTE have emerged. In this review, we describe the anti-inflammatory and anticancer effects of both direct oral anticoagulants (DOACs) and low-molecular-weight heparins (LWMHs). MDPI 2023-09-10 /pmc/articles/PMC10532829/ /pubmed/37763292 http://dx.doi.org/10.3390/life13091888 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Russo, Vincenzo
Falco, Luigi
Tessitore, Viviana
Mauriello, Alfredo
Catapano, Dario
Napolitano, Nicola
Tariq, Moiz
Caturano, Alfredo
Ciccarelli, Giovanni
D’Andrea, Antonello
Giordano, Antonio
Anti-Inflammatory and Anticancer Effects of Anticoagulant Therapy in Patients with Malignancy
title Anti-Inflammatory and Anticancer Effects of Anticoagulant Therapy in Patients with Malignancy
title_full Anti-Inflammatory and Anticancer Effects of Anticoagulant Therapy in Patients with Malignancy
title_fullStr Anti-Inflammatory and Anticancer Effects of Anticoagulant Therapy in Patients with Malignancy
title_full_unstemmed Anti-Inflammatory and Anticancer Effects of Anticoagulant Therapy in Patients with Malignancy
title_short Anti-Inflammatory and Anticancer Effects of Anticoagulant Therapy in Patients with Malignancy
title_sort anti-inflammatory and anticancer effects of anticoagulant therapy in patients with malignancy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532829/
https://www.ncbi.nlm.nih.gov/pubmed/37763292
http://dx.doi.org/10.3390/life13091888
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