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Sulfated Polysaccharides from Seaweeds: A Promising Strategy for Combatting Viral Diseases—A Review
The limited availability of treatments for many infectious diseases highlights the need for new treatments, particularly for viral infections. Natural compounds from seaweed are attracting increasing attention for the treatment of various viral diseases, and thousands of novel compounds have been is...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532895/ https://www.ncbi.nlm.nih.gov/pubmed/37755074 http://dx.doi.org/10.3390/md21090461 |
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author | Liyanage, N. M. Nagahawatta, D. P. Jayawardena, Thilina U. Sanjeewa, Kalu Kapuge Asanka Jayawrdhana, H. H. A. C. K. Kim, Jae-Il Jeon, You-Jin |
author_facet | Liyanage, N. M. Nagahawatta, D. P. Jayawardena, Thilina U. Sanjeewa, Kalu Kapuge Asanka Jayawrdhana, H. H. A. C. K. Kim, Jae-Il Jeon, You-Jin |
author_sort | Liyanage, N. M. |
collection | PubMed |
description | The limited availability of treatments for many infectious diseases highlights the need for new treatments, particularly for viral infections. Natural compounds from seaweed are attracting increasing attention for the treatment of various viral diseases, and thousands of novel compounds have been isolated for the development of pharmaceutical products. Seaweed is a rich source of natural bioactive compounds, including polysaccharides. The discovery of algal polysaccharides with antiviral activity has significantly increased in the past few decades. Furthermore, unique polysaccharides isolated from seaweeds, such as carrageenan, alginates, fucoidans, galactans, laminarians, and ulvans, have been shown to act against viral infections. The antiviral mechanisms of these agents are based on their inhibition of DNA or RNA synthesis, viral entry, and viral replication. In this article, we review and provide an inclusive description of the antiviral activities of algal polysaccharides. Additionally, we discuss the challenges and opportunities for developing polysaccharide-based antiviral therapies, including issues related to drug delivery and formulation. Finally, this review highlights the need for further research for fully understanding the potential of seaweed polysaccharides as a source of antiviral agents and for developing effective treatments for viral diseases. |
format | Online Article Text |
id | pubmed-10532895 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105328952023-09-28 Sulfated Polysaccharides from Seaweeds: A Promising Strategy for Combatting Viral Diseases—A Review Liyanage, N. M. Nagahawatta, D. P. Jayawardena, Thilina U. Sanjeewa, Kalu Kapuge Asanka Jayawrdhana, H. H. A. C. K. Kim, Jae-Il Jeon, You-Jin Mar Drugs Review The limited availability of treatments for many infectious diseases highlights the need for new treatments, particularly for viral infections. Natural compounds from seaweed are attracting increasing attention for the treatment of various viral diseases, and thousands of novel compounds have been isolated for the development of pharmaceutical products. Seaweed is a rich source of natural bioactive compounds, including polysaccharides. The discovery of algal polysaccharides with antiviral activity has significantly increased in the past few decades. Furthermore, unique polysaccharides isolated from seaweeds, such as carrageenan, alginates, fucoidans, galactans, laminarians, and ulvans, have been shown to act against viral infections. The antiviral mechanisms of these agents are based on their inhibition of DNA or RNA synthesis, viral entry, and viral replication. In this article, we review and provide an inclusive description of the antiviral activities of algal polysaccharides. Additionally, we discuss the challenges and opportunities for developing polysaccharide-based antiviral therapies, including issues related to drug delivery and formulation. Finally, this review highlights the need for further research for fully understanding the potential of seaweed polysaccharides as a source of antiviral agents and for developing effective treatments for viral diseases. MDPI 2023-08-23 /pmc/articles/PMC10532895/ /pubmed/37755074 http://dx.doi.org/10.3390/md21090461 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Liyanage, N. M. Nagahawatta, D. P. Jayawardena, Thilina U. Sanjeewa, Kalu Kapuge Asanka Jayawrdhana, H. H. A. C. K. Kim, Jae-Il Jeon, You-Jin Sulfated Polysaccharides from Seaweeds: A Promising Strategy for Combatting Viral Diseases—A Review |
title | Sulfated Polysaccharides from Seaweeds: A Promising Strategy for Combatting Viral Diseases—A Review |
title_full | Sulfated Polysaccharides from Seaweeds: A Promising Strategy for Combatting Viral Diseases—A Review |
title_fullStr | Sulfated Polysaccharides from Seaweeds: A Promising Strategy for Combatting Viral Diseases—A Review |
title_full_unstemmed | Sulfated Polysaccharides from Seaweeds: A Promising Strategy for Combatting Viral Diseases—A Review |
title_short | Sulfated Polysaccharides from Seaweeds: A Promising Strategy for Combatting Viral Diseases—A Review |
title_sort | sulfated polysaccharides from seaweeds: a promising strategy for combatting viral diseases—a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532895/ https://www.ncbi.nlm.nih.gov/pubmed/37755074 http://dx.doi.org/10.3390/md21090461 |
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