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Indicators of HSV1 Infection, ECM–Receptor Interaction, and Chromatin Modulation in a Nuclear Family with Schizophrenia
Schizophrenia (SCZ) is a complex psychiatric disorder with high heritability; identifying risk genes is essential for deciphering the disorder’s pathogenesis and developing novel treatments. Using whole-exome sequencing, we screened for mutations within protein-coding sequences in a single family of...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532901/ https://www.ncbi.nlm.nih.gov/pubmed/37763159 http://dx.doi.org/10.3390/jpm13091392 |
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author | Huang, Yen-Chen Ping, Lieh-Yung Hsu, Shih-Hsin Tsai, Hsin-Yao Cheng, Min-Chih |
author_facet | Huang, Yen-Chen Ping, Lieh-Yung Hsu, Shih-Hsin Tsai, Hsin-Yao Cheng, Min-Chih |
author_sort | Huang, Yen-Chen |
collection | PubMed |
description | Schizophrenia (SCZ) is a complex psychiatric disorder with high heritability; identifying risk genes is essential for deciphering the disorder’s pathogenesis and developing novel treatments. Using whole-exome sequencing, we screened for mutations within protein-coding sequences in a single family of patients with SCZ. In a pathway enrichment analysis, we found multiple transmitted variant genes associated with two KEGG pathways: herpes simplex virus 1 (HSV1) infection and the extracellular matrix (ECM)–receptor interaction. When searching for rare variants, six variants, SLC6A19(p.L541R), CYP2E1(p.T376S), NAT10(p.E811D), N4BP1(p.L7V), CBX2(p.S520C), and ZNF460(p.K190E), segregated with SCZ. A bioinformatic analysis showed that three of these mutated genes were associated with chromatin modulation. We found that HSV1 infection, ECM–receptor interaction pathways, and epigenetic mechanisms may contribute to the pathogenesis of SCZ in certain families. The identified polygenetic risk factors from the sample family provide distinctive underlying biological mechanisms of the pathophysiology of SCZ and may be useful in clinical practice and patient care. |
format | Online Article Text |
id | pubmed-10532901 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105329012023-09-28 Indicators of HSV1 Infection, ECM–Receptor Interaction, and Chromatin Modulation in a Nuclear Family with Schizophrenia Huang, Yen-Chen Ping, Lieh-Yung Hsu, Shih-Hsin Tsai, Hsin-Yao Cheng, Min-Chih J Pers Med Article Schizophrenia (SCZ) is a complex psychiatric disorder with high heritability; identifying risk genes is essential for deciphering the disorder’s pathogenesis and developing novel treatments. Using whole-exome sequencing, we screened for mutations within protein-coding sequences in a single family of patients with SCZ. In a pathway enrichment analysis, we found multiple transmitted variant genes associated with two KEGG pathways: herpes simplex virus 1 (HSV1) infection and the extracellular matrix (ECM)–receptor interaction. When searching for rare variants, six variants, SLC6A19(p.L541R), CYP2E1(p.T376S), NAT10(p.E811D), N4BP1(p.L7V), CBX2(p.S520C), and ZNF460(p.K190E), segregated with SCZ. A bioinformatic analysis showed that three of these mutated genes were associated with chromatin modulation. We found that HSV1 infection, ECM–receptor interaction pathways, and epigenetic mechanisms may contribute to the pathogenesis of SCZ in certain families. The identified polygenetic risk factors from the sample family provide distinctive underlying biological mechanisms of the pathophysiology of SCZ and may be useful in clinical practice and patient care. MDPI 2023-09-18 /pmc/articles/PMC10532901/ /pubmed/37763159 http://dx.doi.org/10.3390/jpm13091392 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Huang, Yen-Chen Ping, Lieh-Yung Hsu, Shih-Hsin Tsai, Hsin-Yao Cheng, Min-Chih Indicators of HSV1 Infection, ECM–Receptor Interaction, and Chromatin Modulation in a Nuclear Family with Schizophrenia |
title | Indicators of HSV1 Infection, ECM–Receptor Interaction, and Chromatin Modulation in a Nuclear Family with Schizophrenia |
title_full | Indicators of HSV1 Infection, ECM–Receptor Interaction, and Chromatin Modulation in a Nuclear Family with Schizophrenia |
title_fullStr | Indicators of HSV1 Infection, ECM–Receptor Interaction, and Chromatin Modulation in a Nuclear Family with Schizophrenia |
title_full_unstemmed | Indicators of HSV1 Infection, ECM–Receptor Interaction, and Chromatin Modulation in a Nuclear Family with Schizophrenia |
title_short | Indicators of HSV1 Infection, ECM–Receptor Interaction, and Chromatin Modulation in a Nuclear Family with Schizophrenia |
title_sort | indicators of hsv1 infection, ecm–receptor interaction, and chromatin modulation in a nuclear family with schizophrenia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532901/ https://www.ncbi.nlm.nih.gov/pubmed/37763159 http://dx.doi.org/10.3390/jpm13091392 |
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