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Factors Affecting the Potential Efficacy of Intrauterine Platelet-Rich Plasma Infusion on Thin Endometrium in Women with Recurrent Implantation Failure

Optimizing endometrial thickness (EMT) is crucial for successful embryo implantation, but enhancing thin endometrium remains a significant challenge. Platelet-rich plasma (PRP)-derived therapies have emerged as a promising approach in reproductive medicine due to their capacity to facilitate tissue...

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Autores principales: Lin, Pin-Yao, Lee, Chun-I, Chen, Yi-Chun, Cheng, En-Hui, Huang, Chun-Chia, Chen, Chung-I, Lee, Tsung-Hsien, Lee, Yu-Jen, Lee, Maw-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532920/
https://www.ncbi.nlm.nih.gov/pubmed/37763186
http://dx.doi.org/10.3390/jpm13091419
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author Lin, Pin-Yao
Lee, Chun-I
Chen, Yi-Chun
Cheng, En-Hui
Huang, Chun-Chia
Chen, Chung-I
Lee, Tsung-Hsien
Lee, Yu-Jen
Lee, Maw-Sheng
author_facet Lin, Pin-Yao
Lee, Chun-I
Chen, Yi-Chun
Cheng, En-Hui
Huang, Chun-Chia
Chen, Chung-I
Lee, Tsung-Hsien
Lee, Yu-Jen
Lee, Maw-Sheng
author_sort Lin, Pin-Yao
collection PubMed
description Optimizing endometrial thickness (EMT) is crucial for successful embryo implantation, but enhancing thin endometrium remains a significant challenge. Platelet-rich plasma (PRP)-derived therapies have emerged as a promising approach in reproductive medicine due to their capacity to facilitate tissue repair and regeneration. This study aims to identify the risk factors associated with the failure of intrauterine PRP infusion for thin endometrium in women with recurrent implantation failure (RIF). We retrospectively reviewed data from 77 women with RIF, all exhibiting an EMT of <7 mm. These women underwent programmed hormone therapy for frozen embryo transfer (FET) and received two autologous intrauterine PRP infusions. Following intrauterine PRP-lysate (PL) infusions, the mean increase in EMT was 1.9 ± 1.2 mm, with EMT reaching 7 mm in 86% of the cases (66/77; average EMT, 8.3 mm). We identified an exceedingly thin EMT as a risk factor impacting the therapeutic efficacy in increasing EMT (p = 0.04, OR: 3.16; 95% CI: 1.03–9.67). Additionally, the number of previous uterine surgeries emerged as a prognostic factor for pregnancy failure following PL infusion (p = 0.02, OR: 2.02; 95% CI: 1.12–3.64). Our findings suggest that an extremely thin EMT and a history of numerous uterine surgeries can impede successful pregnancy, even when an optimal EMT is achieved following PRP infusion.
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spelling pubmed-105329202023-09-28 Factors Affecting the Potential Efficacy of Intrauterine Platelet-Rich Plasma Infusion on Thin Endometrium in Women with Recurrent Implantation Failure Lin, Pin-Yao Lee, Chun-I Chen, Yi-Chun Cheng, En-Hui Huang, Chun-Chia Chen, Chung-I Lee, Tsung-Hsien Lee, Yu-Jen Lee, Maw-Sheng J Pers Med Article Optimizing endometrial thickness (EMT) is crucial for successful embryo implantation, but enhancing thin endometrium remains a significant challenge. Platelet-rich plasma (PRP)-derived therapies have emerged as a promising approach in reproductive medicine due to their capacity to facilitate tissue repair and regeneration. This study aims to identify the risk factors associated with the failure of intrauterine PRP infusion for thin endometrium in women with recurrent implantation failure (RIF). We retrospectively reviewed data from 77 women with RIF, all exhibiting an EMT of <7 mm. These women underwent programmed hormone therapy for frozen embryo transfer (FET) and received two autologous intrauterine PRP infusions. Following intrauterine PRP-lysate (PL) infusions, the mean increase in EMT was 1.9 ± 1.2 mm, with EMT reaching 7 mm in 86% of the cases (66/77; average EMT, 8.3 mm). We identified an exceedingly thin EMT as a risk factor impacting the therapeutic efficacy in increasing EMT (p = 0.04, OR: 3.16; 95% CI: 1.03–9.67). Additionally, the number of previous uterine surgeries emerged as a prognostic factor for pregnancy failure following PL infusion (p = 0.02, OR: 2.02; 95% CI: 1.12–3.64). Our findings suggest that an extremely thin EMT and a history of numerous uterine surgeries can impede successful pregnancy, even when an optimal EMT is achieved following PRP infusion. MDPI 2023-09-21 /pmc/articles/PMC10532920/ /pubmed/37763186 http://dx.doi.org/10.3390/jpm13091419 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lin, Pin-Yao
Lee, Chun-I
Chen, Yi-Chun
Cheng, En-Hui
Huang, Chun-Chia
Chen, Chung-I
Lee, Tsung-Hsien
Lee, Yu-Jen
Lee, Maw-Sheng
Factors Affecting the Potential Efficacy of Intrauterine Platelet-Rich Plasma Infusion on Thin Endometrium in Women with Recurrent Implantation Failure
title Factors Affecting the Potential Efficacy of Intrauterine Platelet-Rich Plasma Infusion on Thin Endometrium in Women with Recurrent Implantation Failure
title_full Factors Affecting the Potential Efficacy of Intrauterine Platelet-Rich Plasma Infusion on Thin Endometrium in Women with Recurrent Implantation Failure
title_fullStr Factors Affecting the Potential Efficacy of Intrauterine Platelet-Rich Plasma Infusion on Thin Endometrium in Women with Recurrent Implantation Failure
title_full_unstemmed Factors Affecting the Potential Efficacy of Intrauterine Platelet-Rich Plasma Infusion on Thin Endometrium in Women with Recurrent Implantation Failure
title_short Factors Affecting the Potential Efficacy of Intrauterine Platelet-Rich Plasma Infusion on Thin Endometrium in Women with Recurrent Implantation Failure
title_sort factors affecting the potential efficacy of intrauterine platelet-rich plasma infusion on thin endometrium in women with recurrent implantation failure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532920/
https://www.ncbi.nlm.nih.gov/pubmed/37763186
http://dx.doi.org/10.3390/jpm13091419
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