Cargando…
Association between Proteinuria Status and Risk of Hypertension: A Nationwide Population-Based Cohort Study
Proteinuria is associated with cardiovascular disease. However, the relationship between changes in proteinuria status and hypertension remains unclear. This study aimed to explore the association between changes in proteinuria status and the risk of developing hypertension with the data from the Ko...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533010/ https://www.ncbi.nlm.nih.gov/pubmed/37763181 http://dx.doi.org/10.3390/jpm13091414 |
_version_ | 1785112096439009280 |
---|---|
author | Lee, Hyungwoo Park, Moo-Suk Kang, Min Kyoung Song, Tae-Jin |
author_facet | Lee, Hyungwoo Park, Moo-Suk Kang, Min Kyoung Song, Tae-Jin |
author_sort | Lee, Hyungwoo |
collection | PubMed |
description | Proteinuria is associated with cardiovascular disease. However, the relationship between changes in proteinuria status and hypertension remains unclear. This study aimed to explore the association between changes in proteinuria status and the risk of developing hypertension with the data from the Korean National Health Insurance Database. We included participants without prior hypertension history who underwent their first health examination in 2003–2004 and a second examination in 2005–2006. Based on their proteinuria status during these two examinations, participants were classified into four groups: the proteinuria-free, proteinuria-resolved, proteinuria-developed, and chronic proteinuria groups. The study outcome was the incidence of hypertension. The study included 935,723 participants followed for a median of 14.2 years (mean age: 40.96 ± 11.01, 62.5% male participants). During this period, 346,686 (37.1%) cases of hypertension were reported. The chronic proteinuria group had the highest hypertension risk, followed by the proteinuria-developed, proteinuria-resolved, and proteinuria-free groups (p < 0.001). Those who recovered from proteinuria had a lower risk of developing hypertension than those with chronic proteinuria (hazard ratio: 0.58; 95% confidence interval: 0.53–0.63, p < 0.001). In contrast, individuals who developed proteinuria had a higher risk of hypertension than proteinuria-free individuals (hazard ratio: 1.31; 95% confidence interval: 1.26–1.35, p < 0.001). Our findings suggest a significant association between proteinuria status changes and hypertension. Effective management of proteinuria may potentially decrease the risk of developing hypertension. |
format | Online Article Text |
id | pubmed-10533010 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105330102023-09-28 Association between Proteinuria Status and Risk of Hypertension: A Nationwide Population-Based Cohort Study Lee, Hyungwoo Park, Moo-Suk Kang, Min Kyoung Song, Tae-Jin J Pers Med Article Proteinuria is associated with cardiovascular disease. However, the relationship between changes in proteinuria status and hypertension remains unclear. This study aimed to explore the association between changes in proteinuria status and the risk of developing hypertension with the data from the Korean National Health Insurance Database. We included participants without prior hypertension history who underwent their first health examination in 2003–2004 and a second examination in 2005–2006. Based on their proteinuria status during these two examinations, participants were classified into four groups: the proteinuria-free, proteinuria-resolved, proteinuria-developed, and chronic proteinuria groups. The study outcome was the incidence of hypertension. The study included 935,723 participants followed for a median of 14.2 years (mean age: 40.96 ± 11.01, 62.5% male participants). During this period, 346,686 (37.1%) cases of hypertension were reported. The chronic proteinuria group had the highest hypertension risk, followed by the proteinuria-developed, proteinuria-resolved, and proteinuria-free groups (p < 0.001). Those who recovered from proteinuria had a lower risk of developing hypertension than those with chronic proteinuria (hazard ratio: 0.58; 95% confidence interval: 0.53–0.63, p < 0.001). In contrast, individuals who developed proteinuria had a higher risk of hypertension than proteinuria-free individuals (hazard ratio: 1.31; 95% confidence interval: 1.26–1.35, p < 0.001). Our findings suggest a significant association between proteinuria status changes and hypertension. Effective management of proteinuria may potentially decrease the risk of developing hypertension. MDPI 2023-09-20 /pmc/articles/PMC10533010/ /pubmed/37763181 http://dx.doi.org/10.3390/jpm13091414 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lee, Hyungwoo Park, Moo-Suk Kang, Min Kyoung Song, Tae-Jin Association between Proteinuria Status and Risk of Hypertension: A Nationwide Population-Based Cohort Study |
title | Association between Proteinuria Status and Risk of Hypertension: A Nationwide Population-Based Cohort Study |
title_full | Association between Proteinuria Status and Risk of Hypertension: A Nationwide Population-Based Cohort Study |
title_fullStr | Association between Proteinuria Status and Risk of Hypertension: A Nationwide Population-Based Cohort Study |
title_full_unstemmed | Association between Proteinuria Status and Risk of Hypertension: A Nationwide Population-Based Cohort Study |
title_short | Association between Proteinuria Status and Risk of Hypertension: A Nationwide Population-Based Cohort Study |
title_sort | association between proteinuria status and risk of hypertension: a nationwide population-based cohort study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533010/ https://www.ncbi.nlm.nih.gov/pubmed/37763181 http://dx.doi.org/10.3390/jpm13091414 |
work_keys_str_mv | AT leehyungwoo associationbetweenproteinuriastatusandriskofhypertensionanationwidepopulationbasedcohortstudy AT parkmoosuk associationbetweenproteinuriastatusandriskofhypertensionanationwidepopulationbasedcohortstudy AT kangminkyoung associationbetweenproteinuriastatusandriskofhypertensionanationwidepopulationbasedcohortstudy AT songtaejin associationbetweenproteinuriastatusandriskofhypertensionanationwidepopulationbasedcohortstudy |