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Association between Proteinuria Status and Risk of Hypertension: A Nationwide Population-Based Cohort Study

Proteinuria is associated with cardiovascular disease. However, the relationship between changes in proteinuria status and hypertension remains unclear. This study aimed to explore the association between changes in proteinuria status and the risk of developing hypertension with the data from the Ko...

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Autores principales: Lee, Hyungwoo, Park, Moo-Suk, Kang, Min Kyoung, Song, Tae-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533010/
https://www.ncbi.nlm.nih.gov/pubmed/37763181
http://dx.doi.org/10.3390/jpm13091414
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author Lee, Hyungwoo
Park, Moo-Suk
Kang, Min Kyoung
Song, Tae-Jin
author_facet Lee, Hyungwoo
Park, Moo-Suk
Kang, Min Kyoung
Song, Tae-Jin
author_sort Lee, Hyungwoo
collection PubMed
description Proteinuria is associated with cardiovascular disease. However, the relationship between changes in proteinuria status and hypertension remains unclear. This study aimed to explore the association between changes in proteinuria status and the risk of developing hypertension with the data from the Korean National Health Insurance Database. We included participants without prior hypertension history who underwent their first health examination in 2003–2004 and a second examination in 2005–2006. Based on their proteinuria status during these two examinations, participants were classified into four groups: the proteinuria-free, proteinuria-resolved, proteinuria-developed, and chronic proteinuria groups. The study outcome was the incidence of hypertension. The study included 935,723 participants followed for a median of 14.2 years (mean age: 40.96 ± 11.01, 62.5% male participants). During this period, 346,686 (37.1%) cases of hypertension were reported. The chronic proteinuria group had the highest hypertension risk, followed by the proteinuria-developed, proteinuria-resolved, and proteinuria-free groups (p < 0.001). Those who recovered from proteinuria had a lower risk of developing hypertension than those with chronic proteinuria (hazard ratio: 0.58; 95% confidence interval: 0.53–0.63, p < 0.001). In contrast, individuals who developed proteinuria had a higher risk of hypertension than proteinuria-free individuals (hazard ratio: 1.31; 95% confidence interval: 1.26–1.35, p < 0.001). Our findings suggest a significant association between proteinuria status changes and hypertension. Effective management of proteinuria may potentially decrease the risk of developing hypertension.
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spelling pubmed-105330102023-09-28 Association between Proteinuria Status and Risk of Hypertension: A Nationwide Population-Based Cohort Study Lee, Hyungwoo Park, Moo-Suk Kang, Min Kyoung Song, Tae-Jin J Pers Med Article Proteinuria is associated with cardiovascular disease. However, the relationship between changes in proteinuria status and hypertension remains unclear. This study aimed to explore the association between changes in proteinuria status and the risk of developing hypertension with the data from the Korean National Health Insurance Database. We included participants without prior hypertension history who underwent their first health examination in 2003–2004 and a second examination in 2005–2006. Based on their proteinuria status during these two examinations, participants were classified into four groups: the proteinuria-free, proteinuria-resolved, proteinuria-developed, and chronic proteinuria groups. The study outcome was the incidence of hypertension. The study included 935,723 participants followed for a median of 14.2 years (mean age: 40.96 ± 11.01, 62.5% male participants). During this period, 346,686 (37.1%) cases of hypertension were reported. The chronic proteinuria group had the highest hypertension risk, followed by the proteinuria-developed, proteinuria-resolved, and proteinuria-free groups (p < 0.001). Those who recovered from proteinuria had a lower risk of developing hypertension than those with chronic proteinuria (hazard ratio: 0.58; 95% confidence interval: 0.53–0.63, p < 0.001). In contrast, individuals who developed proteinuria had a higher risk of hypertension than proteinuria-free individuals (hazard ratio: 1.31; 95% confidence interval: 1.26–1.35, p < 0.001). Our findings suggest a significant association between proteinuria status changes and hypertension. Effective management of proteinuria may potentially decrease the risk of developing hypertension. MDPI 2023-09-20 /pmc/articles/PMC10533010/ /pubmed/37763181 http://dx.doi.org/10.3390/jpm13091414 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Hyungwoo
Park, Moo-Suk
Kang, Min Kyoung
Song, Tae-Jin
Association between Proteinuria Status and Risk of Hypertension: A Nationwide Population-Based Cohort Study
title Association between Proteinuria Status and Risk of Hypertension: A Nationwide Population-Based Cohort Study
title_full Association between Proteinuria Status and Risk of Hypertension: A Nationwide Population-Based Cohort Study
title_fullStr Association between Proteinuria Status and Risk of Hypertension: A Nationwide Population-Based Cohort Study
title_full_unstemmed Association between Proteinuria Status and Risk of Hypertension: A Nationwide Population-Based Cohort Study
title_short Association between Proteinuria Status and Risk of Hypertension: A Nationwide Population-Based Cohort Study
title_sort association between proteinuria status and risk of hypertension: a nationwide population-based cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533010/
https://www.ncbi.nlm.nih.gov/pubmed/37763181
http://dx.doi.org/10.3390/jpm13091414
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